Iron in PDB 7zih: Crystal Structure of Human Tryptophan Hydroxylase 1 in Complex with Inhibitor Ag-01-128

Enzymatic activity of Crystal Structure of Human Tryptophan Hydroxylase 1 in Complex with Inhibitor Ag-01-128

All present enzymatic activity of Crystal Structure of Human Tryptophan Hydroxylase 1 in Complex with Inhibitor Ag-01-128:
1.14.16.4;

Protein crystallography data

The structure of Crystal Structure of Human Tryptophan Hydroxylase 1 in Complex with Inhibitor Ag-01-128, PDB code: 7zih was solved by A.Schuetz, A.Gogolin, J.Pfeifer, K.Mallow, M.Nazare, E.Specker, U.Heinemann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.47 / 1.47
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 46.88, 57.853, 59.268, 90, 97.54, 90
R / Rfree (%) 14.6 / 17.7

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Human Tryptophan Hydroxylase 1 in Complex with Inhibitor Ag-01-128 (pdb code 7zih). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Human Tryptophan Hydroxylase 1 in Complex with Inhibitor Ag-01-128, PDB code: 7zih:

Iron binding site 1 out of 1 in 7zih

Go back to Iron Binding Sites List in 7zih
Iron binding site 1 out of 1 in the Crystal Structure of Human Tryptophan Hydroxylase 1 in Complex with Inhibitor Ag-01-128


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Human Tryptophan Hydroxylase 1 in Complex with Inhibitor Ag-01-128 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe501

b:11.0
occ:1.00
NAP A:JCR502 2.1 16.1 1.0
NE2 A:HIS272 2.1 13.3 1.0
NE2 A:HIS277 2.1 12.0 1.0
O A:HOH640 2.2 15.0 1.0
OE1 A:GLU317 2.3 14.1 1.0
OE2 A:GLU317 2.3 14.2 1.0
CD A:GLU317 2.6 13.0 1.0
CE1 A:HIS272 3.0 13.6 1.0
CAY A:JCR502 3.0 18.1 1.0
CAU A:JCR502 3.0 15.7 1.0
CE1 A:HIS277 3.0 12.0 1.0
CD2 A:HIS277 3.1 11.6 1.0
CD2 A:HIS272 3.1 12.2 1.0
CAN A:JCR502 3.4 16.6 1.0
CAK A:JCR502 3.5 20.0 1.0
CG A:GLU317 4.1 13.4 1.0
CAZ A:JCR502 4.2 19.3 1.0
ND1 A:HIS272 4.2 13.7 1.0
NAS A:JCR502 4.2 18.3 1.0
ND1 A:HIS277 4.2 11.2 1.0
CG A:HIS272 4.3 13.1 1.0
CG A:HIS277 4.3 11.2 1.0
OE1 A:GLU273 4.3 14.6 1.0
OH A:TYR312 4.5 13.7 1.0
CB A:ALA332 4.6 12.7 1.0
CZ A:PHE250 4.6 21.5 1.0
O A:HOH712 4.8 19.1 1.0
CAG A:JCR502 4.8 21.8 1.0
C8 A:JCR502 4.9 15.8 1.0
CB A:GLU317 5.0 13.1 1.0

Reference:

E.Specker, S.Matthes, R.Wesolowski, A.Schutz, M.Grohmann, N.Alenina, D.Pleimes, K.Mallow, M.Neuenschwander, A.Gogolin, M.Weise, J.Pfeifer, N.Ziebart, U.Heinemann, J.P.Von Kries, M.Nazare, M.Bader. Structure-Based Design of Xanthine-Benzimidazole Derivatives As Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem. V. 65 11126 2022.
ISSN: ISSN 0022-2623
PubMed: 35921615
DOI: 10.1021/ACS.JMEDCHEM.2C00598
Page generated: Fri Aug 9 15:02:53 2024

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