Iron in PDB 8hbe: Structure of Human Soluble Guanylate Cyclase in the Inactive State at 3.1 Angstrom

All present enzymatic activity of Structure of Human Soluble Guanylate Cyclase in the Inactive State at 3.1 Angstrom:
4.6.1.2;

The binding sites of Iron atom in the Structure of Human Soluble Guanylate Cyclase in the Inactive State at 3.1 Angstrom (pdb code 8hbe). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Structure of Human Soluble Guanylate Cyclase in the Inactive State at 3.1 Angstrom, PDB code: 8hbe:

Iron binding site 1 out of 1 in the Structure of Human Soluble Guanylate Cyclase in the Inactive State at 3.1 Angstrom


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of Human Soluble Guanylate Cyclase in the Inactive State at 3.1 Angstrom within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe1000 b:57.5 occ:1.00 FE B:HEM1000 0.0 57.5 1.0 ND B:HEM1000 1.9 43.0 1.0 NA B:HEM1000 2.0 44.0 1.0 NC B:HEM1000 2.1 39.8 1.0 NB B:HEM1000 2.1 42.1 1.0 NE2 B:HIS105 2.6 44.7 1.0 C4D B:HEM1000 2.9 37.3 1.0 C1D B:HEM1000 2.9 39.7 1.0 C1A B:HEM1000 2.9 41.7 1.0 C4C B:HEM1000 3.0 34.7 1.0 C4A B:HEM1000 3.0 41.5 1.0 C1B B:HEM1000 3.1 39.6 1.0 C4B B:HEM1000 3.1 36.4 1.0 C1C B:HEM1000 3.1 37.5 1.0 CHA B:HEM1000 3.3 40.2 1.0 CHD B:HEM1000 3.4 36.5 1.0 CE1 B:HIS105 3.5 45.7 1.0 CHB B:HEM1000 3.5 43.2 1.0 CHC B:HEM1000 3.5 36.8 1.0 CD2 B:HIS105 3.6 48.4 1.0 CZ B:PHE74 3.7 31.6 1.0 CE2 B:PHE74 3.9 33.8 1.0 C2D B:HEM1000 4.1 41.9 1.0 C3D B:HEM1000 4.1 39.5 1.0 C2A B:HEM1000 4.1 37.2 1.0 C3A B:HEM1000 4.2 36.2 1.0 C3C B:HEM1000 4.3 38.1 1.0 C2C B:HEM1000 4.3 35.2 1.0 C2B B:HEM1000 4.3 33.4 1.0 C3B B:HEM1000 4.3 30.8 1.0 ND1 B:HIS105 4.6 51.9 1.0 CG B:HIS105 4.7 49.8 1.0 CE1 B:PHE74 4.9 39.4 1.0

R.Liu, Y.Kang, L.Chen. No Binds to the Distal Site of Haem in the Fully Activated Soluble Guanylate Cyclase. Nitric Oxide V.-135 17 2023.
ISSN: ESSN 1089-8611
PubMed: 36972843
DOI: 10.1016/J.NIOX.2023.03.002