Iron in PDB 8s5k: Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction
Enzymatic activity of Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction
All present enzymatic activity of Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction:
4.2.1.22;
Iron Binding Sites:
The binding sites of Iron atom in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction
(pdb code 8s5k). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 8 binding sites of Iron where determined in the
Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction, PDB code: 8s5k:
Jump to Iron binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Iron binding site 1 out
of 8 in 8s5k
Go back to
Iron Binding Sites List in 8s5k
Iron binding site 1 out
of 8 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe601
b:91.2
occ:1.00
|
FE
|
A:HEM601
|
0.0
|
91.2
|
1.0
|
|
NC
|
A:HEM601
|
2.0
|
91.2
|
1.0
|
|
NA
|
A:HEM601
|
2.0
|
91.2
|
1.0
|
|
ND
|
A:HEM601
|
2.0
|
91.2
|
1.0
|
|
NB
|
A:HEM601
|
2.0
|
91.2
|
1.0
|
|
NE2
|
A:HIS65
|
2.2
|
95.5
|
1.0
|
|
HB2
|
A:CYS52
|
2.8
|
83.4
|
1.0
|
|
C4D
|
A:HEM601
|
3.0
|
91.2
|
1.0
|
|
C1A
|
A:HEM601
|
3.0
|
91.2
|
1.0
|
|
C1D
|
A:HEM601
|
3.0
|
91.2
|
1.0
|
|
C4A
|
A:HEM601
|
3.0
|
91.2
|
1.0
|
|
C4B
|
A:HEM601
|
3.0
|
91.2
|
1.0
|
|
C1C
|
A:HEM601
|
3.0
|
91.2
|
1.0
|
|
C4C
|
A:HEM601
|
3.1
|
91.2
|
1.0
|
|
C1B
|
A:HEM601
|
3.1
|
91.2
|
1.0
|
|
CD2
|
A:HIS65
|
3.1
|
95.5
|
1.0
|
|
CE1
|
A:HIS65
|
3.2
|
95.5
|
1.0
|
|
HD2
|
A:HIS65
|
3.3
|
95.5
|
1.0
|
|
CHA
|
A:HEM601
|
3.4
|
91.2
|
1.0
|
|
CHC
|
A:HEM601
|
3.4
|
91.2
|
1.0
|
|
CHB
|
A:HEM601
|
3.4
|
91.2
|
1.0
|
|
CHD
|
A:HEM601
|
3.4
|
91.2
|
1.0
|
|
HE1
|
A:HIS65
|
3.4
|
95.5
|
1.0
|
|
HD2
|
A:PRO64
|
3.7
|
91.1
|
1.0
|
|
CB
|
A:CYS52
|
3.7
|
83.4
|
1.0
|
|
HB3
|
A:CYS52
|
3.8
|
83.4
|
1.0
|
|
HB2
|
A:TRP54
|
4.1
|
92.1
|
1.0
|
|
HA
|
A:CYS52
|
4.2
|
83.4
|
1.0
|
|
C3D
|
A:HEM601
|
4.2
|
91.2
|
1.0
|
|
C2A
|
A:HEM601
|
4.2
|
91.2
|
1.0
|
|
C2D
|
A:HEM601
|
4.2
|
91.2
|
1.0
|
|
H
|
A:THR53
|
4.2
|
92.3
|
1.0
|
|
C3A
|
A:HEM601
|
4.2
|
91.2
|
1.0
|
|
C3B
|
A:HEM601
|
4.3
|
91.2
|
1.0
|
|
C2B
|
A:HEM601
|
4.3
|
91.2
|
1.0
|
|
C2C
|
A:HEM601
|
4.3
|
91.2
|
1.0
|
|
C3C
|
A:HEM601
|
4.3
|
91.2
|
1.0
|
|
CG
|
A:HIS65
|
4.3
|
95.5
|
1.0
|
|
ND1
|
A:HIS65
|
4.3
|
95.5
|
1.0
|
|
HHA
|
A:HEM601
|
4.4
|
91.2
|
1.0
|
|
HHC
|
A:HEM601
|
4.4
|
91.2
|
1.0
|
|
HHD
|
A:HEM601
|
4.4
|
91.2
|
1.0
|
|
HHB
|
A:HEM601
|
4.4
|
91.2
|
1.0
|
|
HD21
|
A:LEU230
|
4.4
|
83.2
|
1.0
|
|
CA
|
A:CYS52
|
4.5
|
83.4
|
1.0
|
|
H
|
A:TRP54
|
4.5
|
92.1
|
1.0
|
|
CD
|
A:PRO64
|
4.6
|
91.1
|
1.0
|
|
HH12
|
A:ARG266
|
4.6
|
85.3
|
1.0
|
|
HG2
|
A:PRO64
|
4.7
|
91.1
|
1.0
|
|
HD3
|
A:PRO64
|
4.7
|
91.1
|
1.0
|
|
SG
|
A:CYS52
|
4.9
|
83.4
|
1.0
|
|
CB
|
A:TRP54
|
4.9
|
92.1
|
1.0
|
|
N
|
A:THR53
|
4.9
|
92.3
|
1.0
|
|
HB3
|
A:TRP54
|
4.9
|
92.1
|
1.0
|
|
Iron binding site 2 out
of 8 in 8s5k
Go back to
Iron Binding Sites List in 8s5k
Iron binding site 2 out
of 8 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Fe601
b:101.5
occ:1.00
|
FE
|
B:HEM601
|
0.0
|
101.5
|
1.0
|
|
NC
|
B:HEM601
|
2.0
|
101.5
|
1.0
|
|
NA
|
B:HEM601
|
2.0
|
101.5
|
1.0
|
|
NB
|
B:HEM601
|
2.0
|
101.5
|
1.0
|
|
ND
|
B:HEM601
|
2.0
|
101.5
|
1.0
|
|
HB2
|
B:CYS52
|
2.5
|
98.2
|
1.0
|
|
C1D
|
B:HEM601
|
3.0
|
101.5
|
1.0
|
|
C4D
|
B:HEM601
|
3.0
|
101.5
|
1.0
|
|
C4C
|
B:HEM601
|
3.0
|
101.5
|
1.0
|
|
C1C
|
B:HEM601
|
3.0
|
101.5
|
1.0
|
|
C1A
|
B:HEM601
|
3.1
|
101.5
|
1.0
|
|
C1B
|
B:HEM601
|
3.1
|
101.5
|
1.0
|
|
C4A
|
B:HEM601
|
3.1
|
101.5
|
1.0
|
|
C4B
|
B:HEM601
|
3.1
|
101.5
|
1.0
|
|
HD2
|
B:HIS65
|
3.2
|
97.8
|
1.0
|
|
HD2
|
B:PRO64
|
3.3
|
106.2
|
1.0
|
|
CB
|
B:CYS52
|
3.3
|
98.2
|
1.0
|
|
HB3
|
B:CYS52
|
3.4
|
98.2
|
1.0
|
|
CHA
|
B:HEM601
|
3.4
|
101.5
|
1.0
|
|
CHD
|
B:HEM601
|
3.4
|
101.5
|
1.0
|
|
CHB
|
B:HEM601
|
3.4
|
101.5
|
1.0
|
|
CHC
|
B:HEM601
|
3.4
|
101.5
|
1.0
|
|
HA
|
B:CYS52
|
3.7
|
98.2
|
1.0
|
|
OG
|
B:SER63
|
3.9
|
100.0
|
1.0
|
|
H
|
B:THR53
|
4.0
|
104.2
|
1.0
|
|
HG
|
B:SER63
|
4.1
|
100.0
|
1.0
|
|
CD2
|
B:HIS65
|
4.1
|
97.8
|
1.0
|
|
CA
|
B:CYS52
|
4.1
|
98.2
|
1.0
|
|
CD
|
B:PRO64
|
4.2
|
106.2
|
1.0
|
|
C3D
|
B:HEM601
|
4.2
|
101.5
|
1.0
|
|
C2D
|
B:HEM601
|
4.2
|
101.5
|
1.0
|
|
C3C
|
B:HEM601
|
4.3
|
101.5
|
1.0
|
|
C2C
|
B:HEM601
|
4.3
|
101.5
|
1.0
|
|
C2A
|
B:HEM601
|
4.3
|
101.5
|
1.0
|
|
C2B
|
B:HEM601
|
4.3
|
101.5
|
1.0
|
|
C3A
|
B:HEM601
|
4.3
|
101.5
|
1.0
|
|
C3B
|
B:HEM601
|
4.3
|
101.5
|
1.0
|
|
HHC
|
B:HEM601
|
4.3
|
101.5
|
1.0
|
|
HG2
|
B:PRO64
|
4.3
|
106.2
|
1.0
|
|
HHD
|
B:HEM601
|
4.4
|
101.5
|
1.0
|
|
HHA
|
B:HEM601
|
4.4
|
101.5
|
1.0
|
|
HHB
|
B:HEM601
|
4.4
|
101.5
|
1.0
|
|
HB2
|
B:TRP54
|
4.4
|
103.6
|
1.0
|
|
HD3
|
B:PRO64
|
4.4
|
106.2
|
1.0
|
|
H
|
B:TRP54
|
4.5
|
103.6
|
1.0
|
|
HD22
|
B:LEU230
|
4.6
|
89.4
|
1.0
|
|
N
|
B:THR53
|
4.6
|
104.2
|
1.0
|
|
NE2
|
B:HIS65
|
4.6
|
97.8
|
1.0
|
|
HA
|
B:SER63
|
4.7
|
100.0
|
1.0
|
|
CG
|
B:PRO64
|
4.7
|
106.2
|
1.0
|
|
SG
|
B:CYS52
|
4.7
|
98.2
|
1.0
|
|
HG3
|
B:PRO64
|
4.8
|
106.2
|
1.0
|
|
HB2
|
B:SER63
|
4.8
|
100.0
|
1.0
|
|
C
|
B:CYS52
|
4.8
|
98.2
|
1.0
|
|
CB
|
B:SER63
|
4.9
|
100.0
|
1.0
|
|
HH12
|
B:ARG266
|
4.9
|
93.6
|
1.0
|
|
Iron binding site 3 out
of 8 in 8s5k
Go back to
Iron Binding Sites List in 8s5k
Iron binding site 3 out
of 8 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Fe601
b:26.7
occ:1.00
|
FE
|
C:HEM601
|
0.0
|
26.7
|
1.0
|
|
ND
|
C:HEM601
|
2.0
|
26.7
|
1.0
|
|
NB
|
C:HEM601
|
2.0
|
26.7
|
1.0
|
|
NC
|
C:HEM601
|
2.0
|
26.7
|
1.0
|
|
NA
|
C:HEM601
|
2.0
|
26.7
|
1.0
|
|
HB2
|
C:CYS52
|
2.8
|
32.5
|
1.0
|
|
NE2
|
C:HIS65
|
2.9
|
31.2
|
1.0
|
|
C4C
|
C:HEM601
|
3.0
|
26.7
|
1.0
|
|
C1D
|
C:HEM601
|
3.0
|
26.7
|
1.0
|
|
C1B
|
C:HEM601
|
3.0
|
26.7
|
1.0
|
|
HD2
|
C:HIS65
|
3.0
|
31.2
|
1.0
|
|
C4A
|
C:HEM601
|
3.0
|
26.7
|
1.0
|
|
C4B
|
C:HEM601
|
3.0
|
26.7
|
1.0
|
|
C1C
|
C:HEM601
|
3.0
|
26.7
|
1.0
|
|
C1A
|
C:HEM601
|
3.0
|
26.7
|
1.0
|
|
C4D
|
C:HEM601
|
3.0
|
26.7
|
1.0
|
|
CD2
|
C:HIS65
|
3.3
|
31.2
|
1.0
|
|
CHD
|
C:HEM601
|
3.4
|
26.7
|
1.0
|
|
CHB
|
C:HEM601
|
3.4
|
26.7
|
1.0
|
|
CHC
|
C:HEM601
|
3.4
|
26.7
|
1.0
|
|
CHA
|
C:HEM601
|
3.4
|
26.7
|
1.0
|
|
CB
|
C:CYS52
|
3.7
|
32.5
|
1.0
|
|
HB3
|
C:CYS52
|
3.8
|
32.5
|
1.0
|
|
HA
|
C:CYS52
|
4.1
|
32.5
|
1.0
|
|
HB2
|
C:TRP54
|
4.1
|
34.4
|
1.0
|
|
CE1
|
C:HIS65
|
4.2
|
31.2
|
1.0
|
|
HD2
|
C:PRO64
|
4.2
|
32.5
|
1.0
|
|
C3C
|
C:HEM601
|
4.2
|
26.7
|
1.0
|
|
C2D
|
C:HEM601
|
4.2
|
26.7
|
1.0
|
|
C2C
|
C:HEM601
|
4.2
|
26.7
|
1.0
|
|
C2B
|
C:HEM601
|
4.2
|
26.7
|
1.0
|
|
C3A
|
C:HEM601
|
4.2
|
26.7
|
1.0
|
|
C3B
|
C:HEM601
|
4.2
|
26.7
|
1.0
|
|
C3D
|
C:HEM601
|
4.2
|
26.7
|
1.0
|
|
C2A
|
C:HEM601
|
4.2
|
26.7
|
1.0
|
|
HH12
|
C:ARG266
|
4.3
|
28.6
|
1.0
|
|
HHD
|
C:HEM601
|
4.3
|
26.7
|
1.0
|
|
HHB
|
C:HEM601
|
4.4
|
26.7
|
1.0
|
|
HHC
|
C:HEM601
|
4.4
|
26.7
|
1.0
|
|
HHA
|
C:HEM601
|
4.4
|
26.7
|
1.0
|
|
H
|
C:TRP54
|
4.5
|
34.4
|
1.0
|
|
CA
|
C:CYS52
|
4.5
|
32.5
|
1.0
|
|
H
|
C:THR53
|
4.5
|
38.5
|
1.0
|
|
HB3
|
C:TRP54
|
4.6
|
34.4
|
1.0
|
|
HE1
|
C:HIS65
|
4.6
|
31.2
|
1.0
|
|
CG
|
C:HIS65
|
4.6
|
31.2
|
1.0
|
|
CB
|
C:TRP54
|
4.8
|
34.4
|
1.0
|
|
HG2
|
C:PRO64
|
4.8
|
32.5
|
1.0
|
|
SG
|
C:CYS52
|
4.9
|
32.5
|
1.0
|
|
NH1
|
C:ARG266
|
4.9
|
28.6
|
1.0
|
|
Iron binding site 4 out
of 8 in 8s5k
Go back to
Iron Binding Sites List in 8s5k
Iron binding site 4 out
of 8 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Fe601
b:31.1
occ:1.00
|
FE
|
D:HEM601
|
0.0
|
31.1
|
1.0
|
|
NC
|
D:HEM601
|
2.0
|
31.1
|
1.0
|
|
ND
|
D:HEM601
|
2.0
|
31.1
|
1.0
|
|
NA
|
D:HEM601
|
2.0
|
31.1
|
1.0
|
|
NB
|
D:HEM601
|
2.0
|
31.1
|
1.0
|
|
NE2
|
D:HIS65
|
2.2
|
31.0
|
1.0
|
|
HB2
|
D:CYS52
|
2.9
|
35.5
|
1.0
|
|
C1A
|
D:HEM601
|
3.0
|
31.1
|
1.0
|
|
C4A
|
D:HEM601
|
3.0
|
31.1
|
1.0
|
|
C1C
|
D:HEM601
|
3.0
|
31.1
|
1.0
|
|
C4D
|
D:HEM601
|
3.0
|
31.1
|
1.0
|
|
C4C
|
D:HEM601
|
3.0
|
31.1
|
1.0
|
|
C1B
|
D:HEM601
|
3.0
|
31.1
|
1.0
|
|
C1D
|
D:HEM601
|
3.0
|
31.1
|
1.0
|
|
C4B
|
D:HEM601
|
3.0
|
31.1
|
1.0
|
|
CD2
|
D:HIS65
|
3.0
|
31.0
|
1.0
|
|
HD2
|
D:HIS65
|
3.1
|
31.0
|
1.0
|
|
CE1
|
D:HIS65
|
3.4
|
31.0
|
1.0
|
|
CHA
|
D:HEM601
|
3.4
|
31.1
|
1.0
|
|
CHC
|
D:HEM601
|
3.4
|
31.1
|
1.0
|
|
CHB
|
D:HEM601
|
3.4
|
31.1
|
1.0
|
|
CHD
|
D:HEM601
|
3.4
|
31.1
|
1.0
|
|
HE1
|
D:HIS65
|
3.6
|
31.0
|
1.0
|
|
CB
|
D:CYS52
|
3.7
|
35.5
|
1.0
|
|
HB3
|
D:CYS52
|
3.7
|
35.5
|
1.0
|
|
HD2
|
D:PRO64
|
4.0
|
32.5
|
1.0
|
|
HA
|
D:CYS52
|
4.1
|
35.5
|
1.0
|
|
C2A
|
D:HEM601
|
4.2
|
31.1
|
1.0
|
|
C3A
|
D:HEM601
|
4.2
|
31.1
|
1.0
|
|
C3D
|
D:HEM601
|
4.2
|
31.1
|
1.0
|
|
C2C
|
D:HEM601
|
4.2
|
31.1
|
1.0
|
|
C3C
|
D:HEM601
|
4.2
|
31.1
|
1.0
|
|
HB2
|
D:TRP54
|
4.3
|
38.3
|
1.0
|
|
C2D
|
D:HEM601
|
4.3
|
31.1
|
1.0
|
|
C2B
|
D:HEM601
|
4.3
|
31.1
|
1.0
|
|
C3B
|
D:HEM601
|
4.3
|
31.1
|
1.0
|
|
HHC
|
D:HEM601
|
4.3
|
31.1
|
1.0
|
|
CG
|
D:HIS65
|
4.3
|
31.0
|
1.0
|
|
HHB
|
D:HEM601
|
4.4
|
31.1
|
1.0
|
|
HHA
|
D:HEM601
|
4.4
|
31.1
|
1.0
|
|
HHD
|
D:HEM601
|
4.4
|
31.1
|
1.0
|
|
ND1
|
D:HIS65
|
4.4
|
31.0
|
1.0
|
|
HG2
|
D:PRO64
|
4.5
|
32.5
|
1.0
|
|
CA
|
D:CYS52
|
4.5
|
35.5
|
1.0
|
|
H
|
D:THR53
|
4.6
|
44.5
|
1.0
|
|
H
|
D:TRP54
|
4.7
|
38.3
|
1.0
|
|
HH12
|
D:ARG266
|
4.9
|
29.8
|
1.0
|
|
CD
|
D:PRO64
|
4.9
|
32.5
|
1.0
|
|
HB3
|
D:TRP54
|
4.9
|
38.3
|
1.0
|
|
SG
|
D:CYS52
|
4.9
|
35.5
|
1.0
|
|
Iron binding site 5 out
of 8 in 8s5k
Go back to
Iron Binding Sites List in 8s5k
Iron binding site 5 out
of 8 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 5 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Fe601
b:31.3
occ:1.00
|
FE
|
E:HEM601
|
0.0
|
31.3
|
1.0
|
|
NC
|
E:HEM601
|
2.0
|
31.3
|
1.0
|
|
ND
|
E:HEM601
|
2.0
|
31.3
|
1.0
|
|
NA
|
E:HEM601
|
2.0
|
31.3
|
1.0
|
|
NB
|
E:HEM601
|
2.0
|
31.3
|
1.0
|
|
NE2
|
E:HIS65
|
2.2
|
32.9
|
1.0
|
|
HB2
|
E:CYS52
|
2.8
|
36.7
|
1.0
|
|
C1A
|
E:HEM601
|
3.0
|
31.3
|
1.0
|
|
C4A
|
E:HEM601
|
3.0
|
31.3
|
1.0
|
|
C1C
|
E:HEM601
|
3.0
|
31.3
|
1.0
|
|
C4D
|
E:HEM601
|
3.0
|
31.3
|
1.0
|
|
C4C
|
E:HEM601
|
3.0
|
31.3
|
1.0
|
|
C1B
|
E:HEM601
|
3.0
|
31.3
|
1.0
|
|
C1D
|
E:HEM601
|
3.0
|
31.3
|
1.0
|
|
CD2
|
E:HIS65
|
3.0
|
32.9
|
1.0
|
|
C4B
|
E:HEM601
|
3.0
|
31.3
|
1.0
|
|
HD2
|
E:HIS65
|
3.1
|
32.9
|
1.0
|
|
CE1
|
E:HIS65
|
3.3
|
32.9
|
1.0
|
|
CHB
|
E:HEM601
|
3.4
|
31.3
|
1.0
|
|
CHA
|
E:HEM601
|
3.4
|
31.3
|
1.0
|
|
CHC
|
E:HEM601
|
3.4
|
31.3
|
1.0
|
|
CHD
|
E:HEM601
|
3.4
|
31.3
|
1.0
|
|
HE1
|
E:HIS65
|
3.6
|
32.9
|
1.0
|
|
CB
|
E:CYS52
|
3.7
|
36.7
|
1.0
|
|
HB3
|
E:CYS52
|
3.7
|
36.7
|
1.0
|
|
HD2
|
E:PRO64
|
4.1
|
34.2
|
1.0
|
|
HA
|
E:CYS52
|
4.2
|
36.7
|
1.0
|
|
HB2
|
E:TRP54
|
4.2
|
40.0
|
1.0
|
|
C2A
|
E:HEM601
|
4.2
|
31.3
|
1.0
|
|
C3A
|
E:HEM601
|
4.2
|
31.3
|
1.0
|
|
C3D
|
E:HEM601
|
4.2
|
31.3
|
1.0
|
|
C2C
|
E:HEM601
|
4.2
|
31.3
|
1.0
|
|
C3C
|
E:HEM601
|
4.2
|
31.3
|
1.0
|
|
C2D
|
E:HEM601
|
4.2
|
31.3
|
1.0
|
|
C2B
|
E:HEM601
|
4.2
|
31.3
|
1.0
|
|
HHC
|
E:HEM601
|
4.3
|
31.3
|
1.0
|
|
C3B
|
E:HEM601
|
4.3
|
31.3
|
1.0
|
|
CG
|
E:HIS65
|
4.3
|
32.9
|
1.0
|
|
HHB
|
E:HEM601
|
4.4
|
31.3
|
1.0
|
|
HHA
|
E:HEM601
|
4.4
|
31.3
|
1.0
|
|
ND1
|
E:HIS65
|
4.4
|
32.9
|
1.0
|
|
HHD
|
E:HEM601
|
4.4
|
31.3
|
1.0
|
|
HG2
|
E:PRO64
|
4.4
|
34.2
|
1.0
|
|
CA
|
E:CYS52
|
4.5
|
36.7
|
1.0
|
|
H
|
E:TRP54
|
4.7
|
40.0
|
1.0
|
|
H
|
E:THR53
|
4.7
|
47.6
|
1.0
|
|
HB3
|
E:TRP54
|
4.8
|
40.0
|
1.0
|
|
HH12
|
E:ARG266
|
4.8
|
29.5
|
1.0
|
|
CD
|
E:PRO64
|
4.9
|
34.2
|
1.0
|
|
SG
|
E:CYS52
|
4.9
|
36.7
|
1.0
|
|
CB
|
E:TRP54
|
4.9
|
40.0
|
1.0
|
|
CG
|
E:PRO64
|
5.0
|
34.2
|
1.0
|
|
Iron binding site 6 out
of 8 in 8s5k
Go back to
Iron Binding Sites List in 8s5k
Iron binding site 6 out
of 8 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 6 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Fe601
b:27.8
occ:1.00
|
FE
|
F:HEM601
|
0.0
|
27.8
|
1.0
|
|
NB
|
F:HEM601
|
2.0
|
27.8
|
1.0
|
|
ND
|
F:HEM601
|
2.0
|
27.8
|
1.0
|
|
NC
|
F:HEM601
|
2.0
|
27.8
|
1.0
|
|
NA
|
F:HEM601
|
2.0
|
27.8
|
1.0
|
|
HB2
|
F:CYS52
|
2.8
|
34.3
|
1.0
|
|
NE2
|
F:HIS65
|
2.9
|
31.8
|
1.0
|
|
C4C
|
F:HEM601
|
3.0
|
27.8
|
1.0
|
|
C1D
|
F:HEM601
|
3.0
|
27.8
|
1.0
|
|
C1B
|
F:HEM601
|
3.0
|
27.8
|
1.0
|
|
C4B
|
F:HEM601
|
3.0
|
27.8
|
1.0
|
|
C1C
|
F:HEM601
|
3.0
|
27.8
|
1.0
|
|
C4A
|
F:HEM601
|
3.0
|
27.8
|
1.0
|
|
C4D
|
F:HEM601
|
3.0
|
27.8
|
1.0
|
|
C1A
|
F:HEM601
|
3.0
|
27.8
|
1.0
|
|
HD2
|
F:HIS65
|
3.1
|
31.8
|
1.0
|
|
CD2
|
F:HIS65
|
3.4
|
31.8
|
1.0
|
|
CHD
|
F:HEM601
|
3.4
|
27.8
|
1.0
|
|
CHB
|
F:HEM601
|
3.4
|
27.8
|
1.0
|
|
CHC
|
F:HEM601
|
3.4
|
27.8
|
1.0
|
|
CHA
|
F:HEM601
|
3.4
|
27.8
|
1.0
|
|
CB
|
F:CYS52
|
3.7
|
34.3
|
1.0
|
|
HB3
|
F:CYS52
|
3.8
|
34.3
|
1.0
|
|
HA
|
F:CYS52
|
4.1
|
34.3
|
1.0
|
|
HB2
|
F:TRP54
|
4.1
|
35.0
|
1.0
|
|
CE1
|
F:HIS65
|
4.2
|
31.8
|
1.0
|
|
HD2
|
F:PRO64
|
4.2
|
33.5
|
1.0
|
|
C3C
|
F:HEM601
|
4.2
|
27.8
|
1.0
|
|
C2D
|
F:HEM601
|
4.2
|
27.8
|
1.0
|
|
C2C
|
F:HEM601
|
4.2
|
27.8
|
1.0
|
|
C2B
|
F:HEM601
|
4.2
|
27.8
|
1.0
|
|
C3D
|
F:HEM601
|
4.2
|
27.8
|
1.0
|
|
C3B
|
F:HEM601
|
4.2
|
27.8
|
1.0
|
|
C3A
|
F:HEM601
|
4.2
|
27.8
|
1.0
|
|
C2A
|
F:HEM601
|
4.2
|
27.8
|
1.0
|
|
HH12
|
F:ARG266
|
4.3
|
30.3
|
1.0
|
|
HHD
|
F:HEM601
|
4.3
|
27.8
|
1.0
|
|
HHB
|
F:HEM601
|
4.4
|
27.8
|
1.0
|
|
HHC
|
F:HEM601
|
4.4
|
27.8
|
1.0
|
|
HHA
|
F:HEM601
|
4.4
|
27.8
|
1.0
|
|
H
|
F:TRP54
|
4.4
|
35.0
|
1.0
|
|
H
|
F:THR53
|
4.5
|
41.6
|
1.0
|
|
CA
|
F:CYS52
|
4.5
|
34.3
|
1.0
|
|
HE1
|
F:HIS65
|
4.5
|
31.8
|
1.0
|
|
HB3
|
F:TRP54
|
4.6
|
35.0
|
1.0
|
|
CG
|
F:HIS65
|
4.7
|
31.8
|
1.0
|
|
HG2
|
F:PRO64
|
4.8
|
33.5
|
1.0
|
|
CB
|
F:TRP54
|
4.8
|
35.0
|
1.0
|
|
SG
|
F:CYS52
|
4.9
|
34.3
|
1.0
|
|
NH1
|
F:ARG266
|
5.0
|
30.3
|
1.0
|
|
Iron binding site 7 out
of 8 in 8s5k
Go back to
Iron Binding Sites List in 8s5k
Iron binding site 7 out
of 8 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 7 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
G:Fe601
b:100.7
occ:1.00
|
FE
|
G:HEM601
|
0.0
|
100.7
|
1.0
|
|
NC
|
G:HEM601
|
2.0
|
100.7
|
1.0
|
|
NA
|
G:HEM601
|
2.0
|
100.7
|
1.0
|
|
NB
|
G:HEM601
|
2.0
|
100.7
|
1.0
|
|
ND
|
G:HEM601
|
2.0
|
100.7
|
1.0
|
|
HB2
|
G:CYS52
|
2.5
|
97.5
|
1.0
|
|
C1D
|
G:HEM601
|
3.0
|
100.7
|
1.0
|
|
C4D
|
G:HEM601
|
3.0
|
100.7
|
1.0
|
|
C4C
|
G:HEM601
|
3.0
|
100.7
|
1.0
|
|
C1B
|
G:HEM601
|
3.0
|
100.7
|
1.0
|
|
C1A
|
G:HEM601
|
3.1
|
100.7
|
1.0
|
|
C4A
|
G:HEM601
|
3.1
|
100.7
|
1.0
|
|
C1C
|
G:HEM601
|
3.1
|
100.7
|
1.0
|
|
C4B
|
G:HEM601
|
3.1
|
100.7
|
1.0
|
|
HD2
|
G:HIS65
|
3.3
|
97.3
|
1.0
|
|
CB
|
G:CYS52
|
3.4
|
97.5
|
1.0
|
|
CHA
|
G:HEM601
|
3.4
|
100.7
|
1.0
|
|
CHD
|
G:HEM601
|
3.4
|
100.7
|
1.0
|
|
CHB
|
G:HEM601
|
3.4
|
100.7
|
1.0
|
|
CHC
|
G:HEM601
|
3.4
|
100.7
|
1.0
|
|
HD2
|
G:PRO64
|
3.5
|
106.2
|
1.0
|
|
HB3
|
G:CYS52
|
3.5
|
97.5
|
1.0
|
|
HA
|
G:CYS52
|
3.7
|
97.5
|
1.0
|
|
OG
|
G:SER63
|
3.9
|
97.7
|
1.0
|
|
H
|
G:THR53
|
4.0
|
105.8
|
1.0
|
|
CD2
|
G:HIS65
|
4.1
|
97.3
|
1.0
|
|
CA
|
G:CYS52
|
4.1
|
97.5
|
1.0
|
|
HG
|
G:SER63
|
4.1
|
97.7
|
1.0
|
|
HB2
|
G:TRP54
|
4.2
|
100.7
|
1.0
|
|
C2D
|
G:HEM601
|
4.2
|
100.7
|
1.0
|
|
C3D
|
G:HEM601
|
4.2
|
100.7
|
1.0
|
|
HD3
|
G:PRO64
|
4.2
|
106.2
|
1.0
|
|
C2B
|
G:HEM601
|
4.3
|
100.7
|
1.0
|
|
CD
|
G:PRO64
|
4.3
|
106.2
|
1.0
|
|
C3C
|
G:HEM601
|
4.3
|
100.7
|
1.0
|
|
C2A
|
G:HEM601
|
4.3
|
100.7
|
1.0
|
|
C3A
|
G:HEM601
|
4.3
|
100.7
|
1.0
|
|
C2C
|
G:HEM601
|
4.3
|
100.7
|
1.0
|
|
C3B
|
G:HEM601
|
4.3
|
100.7
|
1.0
|
|
H
|
G:TRP54
|
4.3
|
100.7
|
1.0
|
|
HHC
|
G:HEM601
|
4.3
|
100.7
|
1.0
|
|
HHD
|
G:HEM601
|
4.4
|
100.7
|
1.0
|
|
NE2
|
G:HIS65
|
4.4
|
97.3
|
1.0
|
|
HHA
|
G:HEM601
|
4.4
|
100.7
|
1.0
|
|
HHB
|
G:HEM601
|
4.4
|
100.7
|
1.0
|
|
HA
|
G:SER63
|
4.5
|
97.7
|
1.0
|
|
HD22
|
G:LEU230
|
4.6
|
91.0
|
1.0
|
|
N
|
G:THR53
|
4.6
|
105.8
|
1.0
|
|
SG
|
G:CYS52
|
4.7
|
97.5
|
1.0
|
|
HB2
|
G:SER63
|
4.7
|
97.7
|
1.0
|
|
HH12
|
G:ARG266
|
4.8
|
93.1
|
1.0
|
|
C
|
G:CYS52
|
4.8
|
97.5
|
1.0
|
|
CB
|
G:SER63
|
4.8
|
97.7
|
1.0
|
|
HG2
|
G:PRO64
|
4.9
|
106.2
|
1.0
|
|
N
|
G:TRP54
|
4.9
|
100.7
|
1.0
|
|
CB
|
G:TRP54
|
5.0
|
100.7
|
1.0
|
|
Iron binding site 8 out
of 8 in 8s5k
Go back to
Iron Binding Sites List in 8s5k
Iron binding site 8 out
of 8 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 8 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
H:Fe601
b:92.0
occ:1.00
|
FE
|
H:HEM601
|
0.0
|
92.0
|
1.0
|
|
ND
|
H:HEM601
|
2.0
|
92.0
|
1.0
|
|
NA
|
H:HEM601
|
2.0
|
92.0
|
1.0
|
|
NC
|
H:HEM601
|
2.0
|
92.0
|
1.0
|
|
NB
|
H:HEM601
|
2.0
|
92.0
|
1.0
|
|
NE2
|
H:HIS65
|
2.3
|
95.4
|
1.0
|
|
HB2
|
H:CYS52
|
2.7
|
84.7
|
1.0
|
|
C1A
|
H:HEM601
|
3.0
|
92.0
|
1.0
|
|
C4D
|
H:HEM601
|
3.0
|
92.0
|
1.0
|
|
C1C
|
H:HEM601
|
3.0
|
92.0
|
1.0
|
|
C4B
|
H:HEM601
|
3.0
|
92.0
|
1.0
|
|
C1D
|
H:HEM601
|
3.0
|
92.0
|
1.0
|
|
C4A
|
H:HEM601
|
3.0
|
92.0
|
1.0
|
|
C4C
|
H:HEM601
|
3.1
|
92.0
|
1.0
|
|
C1B
|
H:HEM601
|
3.1
|
92.0
|
1.0
|
|
CD2
|
H:HIS65
|
3.2
|
95.4
|
1.0
|
|
HD2
|
H:HIS65
|
3.3
|
95.4
|
1.0
|
|
CE1
|
H:HIS65
|
3.3
|
95.4
|
1.0
|
|
CHC
|
H:HEM601
|
3.4
|
92.0
|
1.0
|
|
CHA
|
H:HEM601
|
3.4
|
92.0
|
1.0
|
|
CHB
|
H:HEM601
|
3.4
|
92.0
|
1.0
|
|
CHD
|
H:HEM601
|
3.4
|
92.0
|
1.0
|
|
HE1
|
H:HIS65
|
3.5
|
95.4
|
1.0
|
|
CB
|
H:CYS52
|
3.6
|
84.7
|
1.0
|
|
HD2
|
H:PRO64
|
3.6
|
91.5
|
1.0
|
|
HB3
|
H:CYS52
|
3.7
|
84.7
|
1.0
|
|
HB2
|
H:TRP54
|
4.0
|
90.9
|
1.0
|
|
HA
|
H:CYS52
|
4.1
|
84.7
|
1.0
|
|
H
|
H:THR53
|
4.2
|
92.7
|
1.0
|
|
C2A
|
H:HEM601
|
4.2
|
92.0
|
1.0
|
|
C3D
|
H:HEM601
|
4.2
|
92.0
|
1.0
|
|
C3A
|
H:HEM601
|
4.2
|
92.0
|
1.0
|
|
C2D
|
H:HEM601
|
4.2
|
92.0
|
1.0
|
|
C2C
|
H:HEM601
|
4.3
|
92.0
|
1.0
|
|
C3B
|
H:HEM601
|
4.3
|
92.0
|
1.0
|
|
C3C
|
H:HEM601
|
4.3
|
92.0
|
1.0
|
|
C2B
|
H:HEM601
|
4.3
|
92.0
|
1.0
|
|
CG
|
H:HIS65
|
4.3
|
95.4
|
1.0
|
|
HHC
|
H:HEM601
|
4.3
|
92.0
|
1.0
|
|
HHA
|
H:HEM601
|
4.4
|
92.0
|
1.0
|
|
ND1
|
H:HIS65
|
4.4
|
95.4
|
1.0
|
|
HHD
|
H:HEM601
|
4.4
|
92.0
|
1.0
|
|
HHB
|
H:HEM601
|
4.4
|
92.0
|
1.0
|
|
CA
|
H:CYS52
|
4.5
|
84.7
|
1.0
|
|
H
|
H:TRP54
|
4.5
|
90.9
|
1.0
|
|
CD
|
H:PRO64
|
4.5
|
91.5
|
1.0
|
|
HD12
|
H:LEU230
|
4.6
|
85.4
|
1.0
|
|
HD3
|
H:PRO64
|
4.6
|
91.5
|
1.0
|
|
HG2
|
H:PRO64
|
4.7
|
91.5
|
1.0
|
|
HH12
|
H:ARG266
|
4.8
|
87.1
|
1.0
|
|
SG
|
H:CYS52
|
4.8
|
84.7
|
1.0
|
|
CB
|
H:TRP54
|
4.9
|
90.9
|
1.0
|
|
HB3
|
H:TRP54
|
4.9
|
90.9
|
1.0
|
|
N
|
H:THR53
|
4.9
|
92.7
|
1.0
|
|
Reference:
T.J.Mccorvie,
D.Adamoski,
R.A.C.Machado,
J.Tang,
H.J.Bailey,
D.S.M.Ferreira,
C.Strain-Damerell,
A.Basle,
A.L.B.Ambrosio,
S.M.G.Dias,
W.W.Yue.
Architecture and Regulation of Filamentous Human Cystathionine Beta-Synthase. Nat Commun V. 15 2931 2024.
ISSN: ESSN 2041-1723
PubMed: 38575566
DOI: 10.1038/S41467-024-46864-X
Page generated: Sat Aug 10 17:46:13 2024
|
