Iron in PDB 8s5l: Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer

All present enzymatic activity of Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer:
4.2.1.22;

The binding sites of Iron atom in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer (pdb code 8s5l). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer, PDB code: 8s5l:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe601 b:55.0 occ:1.00 FE A:HEM601 0.0 55.0 1.0 NC A:HEM601 2.0 55.0 1.0 ND A:HEM601 2.0 55.0 1.0 NA A:HEM601 2.0 55.0 1.0 NB A:HEM601 2.0 55.0 1.0 NE2 A:HIS65 2.1 57.2 1.0 CE1 A:HIS65 2.8 57.2 1.0 HE1 A:HIS65 2.8 57.2 1.0 HB2 A:CYS52 2.9 56.8 1.0 C1D A:HEM601 2.9 55.0 1.0 SG A:CYS52 3.0 56.8 1.0 C4D A:HEM601 3.0 55.0 1.0 C4A A:HEM601 3.0 55.0 1.0 C1A A:HEM601 3.0 55.0 1.0 C4C A:HEM601 3.0 55.0 1.0 C1C A:HEM601 3.0 55.0 1.0 C1B A:HEM601 3.1 55.0 1.0 C4B A:HEM601 3.1 55.0 1.0 CD2 A:HIS65 3.2 57.2 1.0 CHD A:HEM601 3.4 55.0 1.0 CB A:CYS52 3.4 56.8 1.0 CHA A:HEM601 3.4 55.0 1.0 CHB A:HEM601 3.4 55.0 1.0 CHC A:HEM601 3.4 55.0 1.0 HD2 A:HIS65 3.6 57.2 1.0 HA A:CYS52 3.6 56.8 1.0 ND1 A:HIS65 4.0 57.2 1.0 CA A:CYS52 4.1 56.8 1.0 C2D A:HEM601 4.1 55.0 1.0 C3D A:HEM601 4.1 55.0 1.0 HG A:CYS52 4.1 56.8 1.0 H A:THR53 4.2 59.6 1.0 C3A A:HEM601 4.2 55.0 1.0 C2A A:HEM601 4.2 55.0 1.0 HB3 A:CYS52 4.2 56.8 1.0 C3C A:HEM601 4.2 55.0 1.0 CG A:HIS65 4.2 57.2 1.0 C2C A:HEM601 4.3 55.0 1.0 C2B A:HEM601 4.3 55.0 1.0 C3B A:HEM601 4.3 55.0 1.0 HHD A:HEM601 4.3 55.0 1.0 HHA A:HEM601 4.3 55.0 1.0 HHB A:HEM601 4.4 55.0 1.0 HHC A:HEM601 4.4 55.0 1.0 HD2 A:PRO64 4.4 56.5 1.0 HH12 A:ARG266 4.7 54.8 1.0 HD1 A:HIS65 4.7 57.2 1.0 H A:TRP54 4.7 57.9 1.0 N A:THR53 4.8 59.6 1.0 HB2 A:TRP54 4.8 57.9 1.0 HB2 A:ALA226 4.9 50.8 1.0 C A:CYS52 5.0 56.8 1.0

Iron binding site 2 out of 4 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe601 b:66.4 occ:1.00 FE B:HEM601 0.0 66.4 1.0 NA B:HEM601 2.0 66.4 1.0 NC B:HEM601 2.0 66.4 1.0 ND B:HEM601 2.0 66.4 1.0 NB B:HEM601 2.0 66.4 1.0 NE2 B:HIS65 2.1 68.4 1.0 HB2 B:CYS52 2.8 68.3 1.0 C4D B:HEM601 3.0 66.4 1.0 C1D B:HEM601 3.0 66.4 1.0 C1A B:HEM601 3.0 66.4 1.0 C4C B:HEM601 3.0 66.4 1.0 C1C B:HEM601 3.0 66.4 1.0 C4B B:HEM601 3.0 66.4 1.0 C4A B:HEM601 3.0 66.4 1.0 C1B B:HEM601 3.1 66.4 1.0 CE1 B:HIS65 3.1 68.4 1.0 CD2 B:HIS65 3.2 68.4 1.0 HE1 B:HIS65 3.2 68.4 1.0 CHA B:HEM601 3.3 66.4 1.0 HD2 B:HIS65 3.3 68.4 1.0 CHD B:HEM601 3.4 66.4 1.0 CHC B:HEM601 3.4 66.4 1.0 CHB B:HEM601 3.4 66.4 1.0 HB3 B:CYS52 3.6 68.3 1.0 CB B:CYS52 3.6 68.3 1.0 HD2 B:PRO64 4.0 67.8 1.0 HB2 B:TRP54 4.1 65.6 1.0 C3D B:HEM601 4.2 66.4 1.0 HG2 B:PRO64 4.2 67.8 1.0 C2D B:HEM601 4.2 66.4 1.0 ND1 B:HIS65 4.2 68.4 1.0 HA B:CYS52 4.2 68.3 1.0 C2A B:HEM601 4.2 66.4 1.0 C3C B:HEM601 4.2 66.4 1.0 C2C B:HEM601 4.2 66.4 1.0 C3A B:HEM601 4.2 66.4 1.0 C3B B:HEM601 4.3 66.4 1.0 C2B B:HEM601 4.3 66.4 1.0 CG B:HIS65 4.3 68.4 1.0 HHA B:HEM601 4.3 66.4 1.0 HHD B:HEM601 4.4 66.4 1.0 HHC B:HEM601 4.4 66.4 1.0 HHB B:HEM601 4.4 66.4 1.0 CA B:CYS52 4.5 68.3 1.0 H B:THR53 4.6 69.3 1.0 HH12 B:ARG266 4.6 59.9 1.0 HG3 B:PRO64 4.7 67.8 1.0 H B:TRP54 4.7 65.6 1.0 CG B:PRO64 4.7 67.8 1.0 CD B:PRO64 4.7 67.8 1.0 SG B:CYS52 4.8 68.3 1.0 CB B:TRP54 5.0 65.6 1.0 HD3 B:PRO64 5.0 67.8 1.0 HD1 B:HIS65 5.0 68.4 1.0 HB3 B:TRP54 5.0 65.6 1.0

Iron binding site 3 out of 4 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer within 5.0Å range: probe atom residue distance (Å) B Occ C:Fe601 b:66.2 occ:1.00 FE C:HEM601 0.0 66.2 1.0 NA C:HEM601 2.0 66.2 1.0 NC C:HEM601 2.0 66.2 1.0 ND C:HEM601 2.0 66.2 1.0 NB C:HEM601 2.0 66.2 1.0 NE2 C:HIS65 2.1 67.1 1.0 HB2 C:CYS52 2.6 67.3 1.0 C4D C:HEM601 3.0 66.2 1.0 C1D C:HEM601 3.0 66.2 1.0 C1A C:HEM601 3.0 66.2 1.0 C4C C:HEM601 3.0 66.2 1.0 C1C C:HEM601 3.0 66.2 1.0 C4A C:HEM601 3.0 66.2 1.0 C4B C:HEM601 3.1 66.2 1.0 C1B C:HEM601 3.1 66.2 1.0 CD2 C:HIS65 3.1 67.1 1.0 CE1 C:HIS65 3.1 67.1 1.0 HD2 C:HIS65 3.2 67.1 1.0 HE1 C:HIS65 3.3 67.1 1.0 CHA C:HEM601 3.4 66.2 1.0 CHD C:HEM601 3.4 66.2 1.0 CHC C:HEM601 3.4 66.2 1.0 CHB C:HEM601 3.4 66.2 1.0 CB C:CYS52 3.5 67.3 1.0 HB3 C:CYS52 3.5 67.3 1.0 HD2 C:PRO64 4.0 67.1 1.0 HB2 C:TRP54 4.1 65.1 1.0 C3D C:HEM601 4.2 66.2 1.0 C2D C:HEM601 4.2 66.2 1.0 ND1 C:HIS65 4.2 67.1 1.0 CG C:HIS65 4.2 67.1 1.0 C3C C:HEM601 4.2 66.2 1.0 HA C:CYS52 4.2 67.3 1.0 C2A C:HEM601 4.2 66.2 1.0 C3A C:HEM601 4.2 66.2 1.0 C2C C:HEM601 4.3 66.2 1.0 C3B C:HEM601 4.3 66.2 1.0 C2B C:HEM601 4.3 66.2 1.0 HG2 C:PRO64 4.3 67.1 1.0 HHA C:HEM601 4.3 66.2 1.0 HHD C:HEM601 4.4 66.2 1.0 HHC C:HEM601 4.4 66.2 1.0 HHB C:HEM601 4.4 66.2 1.0 H C:THR53 4.5 68.4 1.0 CA C:CYS52 4.5 67.3 1.0 SG C:CYS52 4.5 67.3 1.0 HH12 C:ARG266 4.6 59.8 1.0 H C:TRP54 4.6 65.1 1.0 CD C:PRO64 4.8 67.1 1.0 HG3 C:PRO64 4.8 67.1 1.0 CG C:PRO64 4.8 67.1 1.0 CB C:TRP54 4.9 65.1 1.0 HB3 C:TRP54 5.0 65.1 1.0 HD1 C:HIS65 5.0 67.1 1.0

Iron binding site 4 out of 4 in the Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Full-Length Human Cystathionine Beta-Synthase, Basal State, Partially Degraded Tetramer within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe601 b:54.1 occ:1.00 FE D:HEM601 0.0 54.1 1.0 NC D:HEM601 2.0 54.1 1.0 ND D:HEM601 2.0 54.1 1.0 NA D:HEM601 2.0 54.1 1.0 NB D:HEM601 2.0 54.1 1.0 NE2 D:HIS65 2.0 57.2 1.0 CE1 D:HIS65 2.8 57.2 1.0 HE1 D:HIS65 2.8 57.2 1.0 HB2 D:CYS52 2.9 56.1 1.0 C1D D:HEM601 2.9 54.1 1.0 SG D:CYS52 3.0 56.1 1.0 C4D D:HEM601 3.0 54.1 1.0 C1A D:HEM601 3.0 54.1 1.0 C4A D:HEM601 3.0 54.1 1.0 C4C D:HEM601 3.0 54.1 1.0 C1C D:HEM601 3.0 54.1 1.0 C1B D:HEM601 3.1 54.1 1.0 C4B D:HEM601 3.1 54.1 1.0 CD2 D:HIS65 3.2 57.2 1.0 CHD D:HEM601 3.4 54.1 1.0 CB D:CYS52 3.4 56.1 1.0 CHA D:HEM601 3.4 54.1 1.0 CHB D:HEM601 3.4 54.1 1.0 CHC D:HEM601 3.4 54.1 1.0 HD2 D:HIS65 3.6 57.2 1.0 HA D:CYS52 3.6 56.1 1.0 ND1 D:HIS65 4.0 57.2 1.0 HG D:CYS52 4.0 56.1 1.0 CA D:CYS52 4.0 56.1 1.0 C2D D:HEM601 4.1 54.1 1.0 C3D D:HEM601 4.1 54.1 1.0 H D:THR53 4.1 59.5 1.0 C3A D:HEM601 4.2 54.1 1.0 C2A D:HEM601 4.2 54.1 1.0 HB3 D:CYS52 4.2 56.1 1.0 C3C D:HEM601 4.2 54.1 1.0 CG D:HIS65 4.2 57.2 1.0 C2C D:HEM601 4.3 54.1 1.0 C2B D:HEM601 4.3 54.1 1.0 C3B D:HEM601 4.3 54.1 1.0 HHD D:HEM601 4.3 54.1 1.0 HHA D:HEM601 4.3 54.1 1.0 HHB D:HEM601 4.4 54.1 1.0 HD2 D:PRO64 4.4 55.5 1.0 HHC D:HEM601 4.4 54.1 1.0 HD1 D:HIS65 4.7 57.2 1.0 N D:THR53 4.8 59.5 1.0 HH12 D:ARG266 4.8 54.2 1.0 HB2 D:ALA226 4.9 51.5 1.0 H D:TRP54 4.9 57.3 1.0 HB2 D:TRP54 4.9 57.3 1.0 C D:CYS52 5.0 56.1 1.0

T.J.Mccorvie, D.Adamoski, R.A.C.Machado, J.Tang, H.J.Bailey, D.S.M.Ferreira, C.Strain-Damerell, A.Basle, A.L.B.Ambrosio, S.M.G.Dias, W.W.Yue. Architecture and Regulation of Filamentous Human Cystathionine Beta-Synthase. Nat Commun V. 15 2931 2024.
ISSN: ESSN 2041-1723
PubMed: 38575566
DOI: 10.1038/S41467-024-46864-X