Iron in PDB 8tlt: REV1(Deltan)-Polzeta-Dna-Dctp Complex

All present enzymatic activity of REV1(Deltan)-Polzeta-Dna-Dctp Complex:
2.7.7.7;

The structure of REV1(Deltan)-Polzeta-Dna-Dctp Complex also contains other interesting chemical elements:

Calcium

(Ca)

1 atom

The binding sites of Iron atom in the REV1(Deltan)-Polzeta-Dna-Dctp Complex (pdb code 8tlt). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the REV1(Deltan)-Polzeta-Dna-Dctp Complex, PDB code: 8tlt:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the REV1(Deltan)-Polzeta-Dna-Dctp Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of REV1(Deltan)-Polzeta-Dna-Dctp Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1601 b:39.2 occ:1.00 FE1 A:SF41601 0.0 39.2 1.0 S4 A:SF41601 2.1 39.2 1.0 S3 A:SF41601 2.1 39.2 1.0 S2 A:SF41601 2.1 39.2 1.0 SG A:CYS1473 2.3 41.2 1.0 FE2 A:SF41601 3.0 39.2 1.0 FE3 A:SF41601 3.0 39.2 1.0 FE4 A:SF41601 3.0 39.2 1.0 CB A:CYS1473 3.1 41.2 1.0 S1 A:SF41601 3.7 39.2 1.0 CB A:VAL1475 3.9 38.0 1.0 N A:PHE1476 4.3 38.4 1.0 CG A:ARG852 4.5 36.1 1.0 CA A:CYS1473 4.5 41.2 1.0 CD A:ARG852 4.5 36.1 1.0 CG1 A:VAL1475 4.5 38.0 1.0 CG2 A:VAL1475 4.6 38.0 1.0 CA A:VAL1475 4.7 38.0 1.0 C A:VAL1475 4.8 38.0 1.0 N A:VAL1475 4.8 38.0 1.0 CB A:PHE1476 4.9 38.4 1.0 NE A:ARG852 4.9 36.1 1.0 C A:CYS1473 5.0 41.2 1.0

Iron binding site 2 out of 4 in the REV1(Deltan)-Polzeta-Dna-Dctp Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of REV1(Deltan)-Polzeta-Dna-Dctp Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1601 b:39.2 occ:1.00 FE2 A:SF41601 0.0 39.2 1.0 S4 A:SF41601 2.1 39.2 1.0 S3 A:SF41601 2.1 39.2 1.0 S1 A:SF41601 2.1 39.2 1.0 SG A:CYS1449 2.3 38.0 1.0 CB A:CYS1449 2.9 38.0 1.0 FE4 A:SF41601 3.0 39.2 1.0 FE3 A:SF41601 3.0 39.2 1.0 FE1 A:SF41601 3.0 39.2 1.0 S2 A:SF41601 3.7 39.2 1.0 CG A:PRO854 4.1 33.0 1.0 CG A:ARG852 4.2 36.1 1.0 CA A:CYS1449 4.4 38.0 1.0 CB A:PRO854 4.6 33.0 1.0 CD A:PRO854 4.6 33.0 1.0 CA A:PRO854 4.7 33.0 1.0 N A:PRO854 4.7 33.0 1.0 C A:CYS1449 4.8 38.0 1.0 O A:CYS1446 4.8 36.6 1.0 CA A:CYS1446 4.9 36.6 1.0 SG A:CYS1473 5.0 41.2 1.0

Iron binding site 3 out of 4 in the REV1(Deltan)-Polzeta-Dna-Dctp Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of REV1(Deltan)-Polzeta-Dna-Dctp Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1601 b:39.2 occ:1.00 FE3 A:SF41601 0.0 39.2 1.0 S1 A:SF41601 2.1 39.2 1.0 S4 A:SF41601 2.1 39.2 1.0 S2 A:SF41601 2.1 39.2 1.0 SG A:CYS1468 2.3 36.3 1.0 FE2 A:SF41601 3.0 39.2 1.0 FE4 A:SF41601 3.0 39.2 1.0 FE1 A:SF41601 3.0 39.2 1.0 CB A:CYS1468 3.4 36.3 1.0 S3 A:SF41601 3.7 39.2 1.0 CA A:PRO854 4.2 33.0 1.0 CB A:SER1470 4.3 38.3 1.0 CB A:PRO854 4.3 33.0 1.0 NH2 A:ARG1479 4.4 39.7 1.0 CA A:CYS1468 4.8 36.3 1.0 CG A:PRO854 4.8 33.0 1.0 N A:SER1470 4.8 38.3 1.0 N A:HIS855 4.9 33.6 1.0 OG A:SER1470 4.9 38.3 1.0 SG A:CYS1446 5.0 36.6 1.0

Iron binding site 4 out of 4 in the REV1(Deltan)-Polzeta-Dna-Dctp Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of REV1(Deltan)-Polzeta-Dna-Dctp Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1601 b:39.2 occ:1.00 FE4 A:SF41601 0.0 39.2 1.0 S1 A:SF41601 2.1 39.2 1.0 S2 A:SF41601 2.1 39.2 1.0 S3 A:SF41601 2.1 39.2 1.0 SG A:CYS1446 2.3 36.6 1.0 FE2 A:SF41601 3.0 39.2 1.0 FE3 A:SF41601 3.0 39.2 1.0 FE1 A:SF41601 3.0 39.2 1.0 CB A:CYS1446 3.3 36.6 1.0 CA A:CYS1446 3.5 36.6 1.0 S4 A:SF41601 3.7 39.2 1.0 CG1 A:VAL1475 4.1 38.0 1.0 N A:CYS1446 4.4 36.6 1.0 NH2 A:ARG1479 4.5 39.7 1.0 CB A:VAL1475 4.5 38.0 1.0 C A:CYS1446 4.6 36.6 1.0 O A:CYS1446 4.7 36.6 1.0 CB A:CYS1449 4.8 38.0 1.0 NE A:ARG1479 4.8 39.7 1.0 SG A:CYS1468 4.9 36.3 1.0

R.Malik, R.E.Johnson, I.B.Ubarretxena, L.Prakash, S.Prakash, A.K.Aggarwal. Cryo-Em Structure of the REV1-Polzeta Holocomplex Reveals the Mechanism of Their Cooperativity in Translesion Dna Synthesis Nat.Struct.Mol.Biol. 2024.
ISSN: ESSN 1545-9985