Iron in PDB 8ucd: Cryo-Em Structure of Human STEAP1 in Complex with Amg 509 Fab

The binding sites of Iron atom in the Cryo-Em Structure of Human STEAP1 in Complex with Amg 509 Fab (pdb code 8ucd). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 3 binding sites of Iron where determined in the Cryo-Em Structure of Human STEAP1 in Complex with Amg 509 Fab, PDB code: 8ucd:
Jump to Iron binding site number: 1; 2; 3;

Iron binding site 1 out of 3 in the Cryo-Em Structure of Human STEAP1 in Complex with Amg 509 Fab


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryo-Em Structure of Human STEAP1 in Complex with Amg 509 Fab within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe404 b:39.3 occ:1.00 FE A:HEM404 0.0 39.3 1.0 ND A:HEM404 2.0 39.3 1.0 NA A:HEM404 2.1 39.3 1.0 NC A:HEM404 2.1 39.3 1.0 NB A:HEM404 2.1 39.3 1.0 NE2 A:HIS268 2.3 24.1 1.0 NE2 A:HIS175 2.9 24.5 1.0 C4A A:HEM404 3.1 39.3 1.0 C1B A:HEM404 3.1 39.3 1.0 C4D A:HEM404 3.1 39.3 1.0 C1D A:HEM404 3.1 39.3 1.0 C1A A:HEM404 3.1 39.3 1.0 C4C A:HEM404 3.1 39.3 1.0 C1C A:HEM404 3.1 39.3 1.0 C4B A:HEM404 3.1 39.3 1.0 CD2 A:HIS268 3.1 24.1 1.0 CE1 A:HIS268 3.3 24.1 1.0 CHB A:HEM404 3.4 39.3 1.0 CHD A:HEM404 3.4 39.3 1.0 CHA A:HEM404 3.4 39.3 1.0 CHC A:HEM404 3.4 39.3 1.0 CD2 A:HIS175 3.7 24.5 1.0 CE1 A:HIS175 3.9 24.5 1.0 CG A:HIS268 4.2 24.1 1.0 ND1 A:HIS268 4.3 24.1 1.0 C3A A:HEM404 4.3 39.3 1.0 C2A A:HEM404 4.3 39.3 1.0 C3D A:HEM404 4.3 39.3 1.0 C2D A:HEM404 4.3 39.3 1.0 C2B A:HEM404 4.3 39.3 1.0 C2C A:HEM404 4.3 39.3 1.0 C3C A:HEM404 4.3 39.3 1.0 C3B A:HEM404 4.3 39.3 1.0 CG A:HIS175 4.9 24.5 1.0 ND1 A:HIS175 5.0 24.5 1.0

Iron binding site 2 out of 3 in the Cryo-Em Structure of Human STEAP1 in Complex with Amg 509 Fab


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryo-Em Structure of Human STEAP1 in Complex with Amg 509 Fab within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe403 b:29.5 occ:1.00 FE B:HEM403 0.0 29.5 1.0 NB B:HEM403 2.1 29.5 1.0 NC B:HEM403 2.1 29.5 1.0 NA B:HEM403 2.1 29.5 1.0 ND B:HEM403 2.1 29.5 1.0 NE2 B:HIS175 2.3 26.4 1.0 NE2 B:HIS268 2.9 25.2 1.0 C4A B:HEM403 3.1 29.5 1.0 C1A B:HEM403 3.1 29.5 1.0 C1B B:HEM403 3.1 29.5 1.0 C1D B:HEM403 3.1 29.5 1.0 C4C B:HEM403 3.1 29.5 1.0 C1C B:HEM403 3.1 29.5 1.0 C4B B:HEM403 3.1 29.5 1.0 C4D B:HEM403 3.1 29.5 1.0 CD2 B:HIS175 3.3 26.4 1.0 CE1 B:HIS175 3.3 26.4 1.0 CHB B:HEM403 3.4 29.5 1.0 CHD B:HEM403 3.4 29.5 1.0 CHA B:HEM403 3.4 29.5 1.0 CHC B:HEM403 3.4 29.5 1.0 CD2 B:HIS268 3.5 25.2 1.0 CE1 B:HIS268 4.0 25.2 1.0 C3A B:HEM403 4.3 29.5 1.0 C2A B:HEM403 4.3 29.5 1.0 C2D B:HEM403 4.3 29.5 1.0 C2B B:HEM403 4.3 29.5 1.0 C3D B:HEM403 4.3 29.5 1.0 C2C B:HEM403 4.3 29.5 1.0 C3C B:HEM403 4.3 29.5 1.0 C3B B:HEM403 4.3 29.5 1.0 ND1 B:HIS175 4.4 26.4 1.0 CG B:HIS175 4.4 26.4 1.0 CG B:HIS268 4.7 25.2 1.0 ND1 B:HIS268 4.9 25.2 1.0

Iron binding site 3 out of 3 in the Cryo-Em Structure of Human STEAP1 in Complex with Amg 509 Fab


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Cryo-Em Structure of Human STEAP1 in Complex with Amg 509 Fab within 5.0Å range: probe atom residue distance (Å) B Occ C:Fe402 b:30.5 occ:1.00 FE C:HEM402 0.0 30.5 1.0 NB C:HEM402 2.1 30.5 1.0 NC C:HEM402 2.1 30.5 1.0 NA C:HEM402 2.1 30.5 1.0 ND C:HEM402 2.1 30.5 1.0 NE2 C:HIS175 2.3 24.9 1.0 NE2 C:HIS268 2.8 27.4 1.0 C4A C:HEM402 3.0 30.5 1.0 C1A C:HEM402 3.1 30.5 1.0 C1B C:HEM402 3.1 30.5 1.0 C4C C:HEM402 3.1 30.5 1.0 C1D C:HEM402 3.1 30.5 1.0 C1C C:HEM402 3.1 30.5 1.0 C4B C:HEM402 3.1 30.5 1.0 C4D C:HEM402 3.1 30.5 1.0 CD2 C:HIS175 3.2 24.9 1.0 CE1 C:HIS175 3.3 24.9 1.0 CHB C:HEM402 3.4 30.5 1.0 CHA C:HEM402 3.4 30.5 1.0 CHD C:HEM402 3.4 30.5 1.0 CHC C:HEM402 3.4 30.5 1.0 CE1 C:HIS268 3.6 27.4 1.0 CD2 C:HIS268 3.7 27.4 1.0 C3A C:HEM402 4.2 30.5 1.0 C2A C:HEM402 4.3 30.5 1.0 C2D C:HEM402 4.3 30.5 1.0 C2C C:HEM402 4.3 30.5 1.0 C2B C:HEM402 4.3 30.5 1.0 C3C C:HEM402 4.3 30.5 1.0 C3D C:HEM402 4.3 30.5 1.0 C3B C:HEM402 4.3 30.5 1.0 ND1 C:HIS175 4.4 24.9 1.0 CG C:HIS175 4.4 24.9 1.0 ND1 C:HIS268 4.7 27.4 1.0 CG C:HIS268 4.8 27.4 1.0

O.Nolan-Stevaux, C.Li, L.Liang, J.Zhan, J.Estrada, T.Osgood, F.Li, H.Zhang, R.Case, C.M.Murawsky, B.Estes, G.L.Moore, M.J.Bernett, U.Muchhal, J.R.Desjarlais, B.K.Staley, J.Stevens, K.S.Cooke, F.Aeffner, O.Thomas, J.Stieglmaier, J.L.Lee, A.Coxon, J.M.Bailis. Amg 509 (Xaluritamig), An Anti-STEAP1 Xmab 2+1 T-Cell Redirecting Immune Therapy with Avidity-Dependent Activity Against Prostate Cancer. Cancer Discov 2023.
ISSN: ESSN 2159-8290
PubMed: 37861452
DOI: 10.1158/2159-8290.CD-23-0984