Iron in PDB 8vz7: Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan

Enzymatic activity of Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan

All present enzymatic activity of Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan:
1.14.14.1; 1.14.14.51; 1.14.14.52; 1.14.14.53;

Protein crystallography data

The structure of Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan, PDB code: 8vz7 was solved by M.B.Shah, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.01 / 2.53
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 74.89, 142.17, 163.07, 90, 90, 90
R / Rfree (%) 15.1 / 21.5

Other elements in 8vz7:

The structure of Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan also contains other interesting chemical elements:

Potassium (K) 1 atom
Chlorine (Cl) 2 atoms

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan (pdb code 8vz7). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan, PDB code: 8vz7:

Iron binding site 1 out of 1 in 8vz7

Go back to Iron Binding Sites List in 8vz7
Iron binding site 1 out of 1 in the Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe501

b:38.3
occ:1.00
 FE A:HEM501 0.0 38.3 1.0
ND A:HEM501 1.8 36.4 1.0
NA A:HEM501 2.0 36.5 1.0
NB A:HEM501 2.1 35.1 1.0
NC A:HEM501 2.1 34.7 1.0
SG A:CYS435 2.2 37.9 1.0
C4D A:HEM501 2.8 35.4 1.0
C1D A:HEM501 2.8 32.5 1.0
C1A A:HEM501 3.0 31.1 1.0
C4C A:HEM501 3.0 35.9 1.0
C4B A:HEM501 3.0 34.0 1.0
C4A A:HEM501 3.0 33.6 1.0
C1B A:HEM501 3.0 32.6 1.0
C1C A:HEM501 3.1 36.8 1.0
O A:HOH707 3.2 49.3 1.0
CHA A:HEM501 3.3 32.0 1.0
CHD A:HEM501 3.3 34.8 1.0
CB A:CYS435 3.4 40.8 1.0
CHB A:HEM501 3.4 33.9 1.0
CHC A:HEM501 3.5 32.3 1.0
C3D A:HEM501 4.0 36.8 1.0
C2D A:HEM501 4.0 33.6 1.0
CA A:CYS435 4.1 43.5 1.0
C2A A:HEM501 4.2 34.9 1.0
C3A A:HEM501 4.2 32.2 1.0
C3C A:HEM501 4.2 38.3 1.0
C2C A:HEM501 4.2 36.3 1.0
C2B A:HEM501 4.2 35.6 1.0
C3B A:HEM501 4.3 33.7 1.0
O A:ALA297 4.4 46.2 1.0
N A:GLY437 4.6 44.3 1.0
CB A:ALA297 4.6 44.4 1.0
C A:CYS435 4.7 42.2 1.0
N A:VAL436 4.8 41.0 1.0
C5 A:LSN502 5.0 54.0 1.0

Reference:

S.J.Parikh, S.Edara, S.Deodhar, A.K.Singh, K.Maekawa, Q.Zhang, K.C.Glass, M.B.Shah. Structural and Biophysical Analysis of Cytochrome P450 2C9*14 and *27 Variants in Complex with Losartan J.Inorg.Biochem. 2024.
ISSN: ISSN 0162-0134
DOI: 10.1016/J.JINORGBIO.2024.112622
Page generated: Sat Aug 10 18:47:26 2024

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