Iron in PDB 8w92: Human H Ferritin with 2 Fe(II)/Subunit Loading

All present enzymatic activity of Human H Ferritin with 2 Fe(II)/Subunit Loading:
1.16.3.1;

The structure of Human H Ferritin with 2 Fe(II)/Subunit Loading, PDB code: 8w92 was solved by T.Zhang, R.Jiao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.20 / 2.12
Space group	F 4 3 2
Cell size a, b, c (Å), α, β, γ (°)	182.22, 182.22, 182.22, 90, 90, 90
R / Rfree (%)	16.5 / 20

The structure of Human H Ferritin with 2 Fe(II)/Subunit Loading also contains other interesting chemical elements:

Calcium

(Ca)

3 atoms

The binding sites of Iron atom in the Human H Ferritin with 2 Fe(II)/Subunit Loading (pdb code 8w92). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 3 binding sites of Iron where determined in the Human H Ferritin with 2 Fe(II)/Subunit Loading, PDB code: 8w92:
Jump to Iron binding site number: 1; 2; 3;

Iron binding site 1 out of 3 in the Human H Ferritin with 2 Fe(II)/Subunit Loading


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human H Ferritin with 2 Fe(II)/Subunit Loading within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe201 b:60.5 occ:0.42 O A:HOH302 2.2 49.6 1.0 OE1 A:GLU62 2.2 52.8 1.0 OE1 A:GLU27 2.5 49.8 1.0 ND1 A:HIS65 2.6 55.0 1.0 OE2 A:GLU62 2.8 61.2 1.0 CD A:GLU62 2.8 50.2 1.0 CE1 A:HIS65 3.4 62.0 1.0 CD A:GLU27 3.5 49.8 1.0 OE1 A:GLN141 3.6 55.8 1.0 CG A:HIS65 3.6 48.3 1.0 FE A:FE202 3.7 71.9 0.6 OE2 A:GLU27 3.8 57.2 1.0 CB A:HIS65 4.0 39.5 1.0 CG1 A:VAL110 4.3 37.4 1.0 CG A:GLU62 4.3 40.7 1.0 CD A:GLN141 4.5 45.7 1.0 NE2 A:HIS65 4.6 67.3 1.0 CA A:GLU62 4.7 36.5 1.0 CD2 A:HIS65 4.7 53.9 1.0 CG A:GLU27 4.7 42.2 1.0 OE1 A:GLU107 4.9 52.7 1.0 CB A:GLU62 4.9 35.6 1.0

Iron binding site 2 out of 3 in the Human H Ferritin with 2 Fe(II)/Subunit Loading


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Human H Ferritin with 2 Fe(II)/Subunit Loading within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe202 b:71.9 occ:0.55 O A:HOH302 2.2 49.6 1.0 O A:HOH375 2.3 57.7 1.0 OE2 A:GLU62 2.6 61.2 1.0 OE1 A:GLN141 2.9 55.8 1.0 OE1 A:GLU107 3.0 52.7 1.0 OE2 A:GLU107 3.2 50.7 1.0 CD A:GLU107 3.4 50.1 1.0 FE A:FE201 3.7 60.5 0.4 CD A:GLU62 3.9 50.2 1.0 CD A:GLN141 3.9 45.7 1.0 CB A:ALA144 4.0 31.3 1.0 CE1 A:HIS65 4.0 62.0 1.0 NE2 A:GLN141 4.2 47.3 1.0 ND1 A:HIS65 4.4 55.0 1.0 OE1 A:GLU62 4.5 52.8 1.0 CG A:GLU107 4.8 41.4 1.0 CG A:GLU62 5.0 40.7 1.0 O A:GLU140 5.0 36.9 1.0

Iron binding site 3 out of 3 in the Human H Ferritin with 2 Fe(II)/Subunit Loading


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Human H Ferritin with 2 Fe(II)/Subunit Loading within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe203 b:68.8 occ:0.36 OD2 A:ASP84 2.2 49.2 1.0 CG A:ASP84 2.9 40.8 1.0 OD1 A:ASP84 3.0 42.2 1.0 O A:HOH342 4.2 49.2 0.5 CB A:ASP84 4.4 33.0 1.0 O A:HOH354 4.4 40.7 1.0

T.Zhang, R.Jiao. Human H Ferritin with 2 Fe(II)/Subunit Loading To Be Published.