Iron in PDB 9b8s: Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State

All present enzymatic activity of Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State:
2.7.7.7;

The binding sites of Iron atom in the Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State (pdb code 9b8s). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State, PDB code: 9b8s:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe2301 b:232.1 occ:1.00 FE1 A:SF42301 0.0 232.1 1.0 S3 A:SF42301 2.3 232.1 1.0 S2 A:SF42301 2.3 232.1 1.0 SG A:CYS663 2.3 200.6 1.0 S4 A:SF42301 2.3 232.1 1.0 FE2 A:SF42301 2.7 232.1 1.0 FE4 A:SF42301 2.7 232.1 1.0 FE3 A:SF42301 2.7 232.1 1.0 CB A:CYS663 3.4 200.6 1.0 OE1 A:GLN748 3.4 152.7 1.0 NE2 A:GLN664 3.5 188.7 1.0 CD A:GLN664 3.8 188.7 1.0 S1 A:SF42301 3.9 232.1 1.0 CB A:PHE656 3.9 210.2 1.0 O A:PHE656 4.0 210.2 1.0 O A:CYS663 4.0 200.6 1.0 NE2 A:GLN748 4.0 152.7 1.0 C A:CYS663 4.1 200.6 1.0 CD A:GLN748 4.1 152.7 1.0 CG A:GLN664 4.3 188.7 1.0 OE1 A:GLN664 4.4 188.7 1.0 CA A:CYS663 4.4 200.6 1.0 C A:PHE656 4.4 210.2 1.0 N A:GLN664 4.5 188.7 1.0 SG A:CYS747 4.5 152.9 1.0 SG A:CYS651 4.7 211.0 1.0 SG A:CYS654 4.7 224.7 1.0 CA A:PHE656 4.8 210.2 1.0

Iron binding site 2 out of 4 in the Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe2301 b:232.1 occ:1.00 FE2 A:SF42301 0.0 232.1 1.0 SG A:CYS654 2.3 224.7 1.0 S4 A:SF42301 2.3 232.1 1.0 S1 A:SF42301 2.3 232.1 1.0 S3 A:SF42301 2.3 232.1 1.0 CB A:CYS654 2.6 224.7 1.0 FE3 A:SF42301 2.7 232.1 1.0 FE4 A:SF42301 2.7 232.1 1.0 FE1 A:SF42301 2.7 232.1 1.0 CB A:PHE656 3.9 210.2 1.0 S2 A:SF42301 3.9 232.1 1.0 O A:CYS651 4.0 211.0 1.0 CA A:CYS654 4.1 224.7 1.0 SG A:CYS747 4.1 152.9 1.0 N A:PHE656 4.2 210.2 1.0 CA A:PHE656 4.4 210.2 1.0 C A:CYS654 4.5 224.7 1.0 SG A:CYS651 4.5 211.0 1.0 C A:PHE656 4.6 210.2 1.0 N A:ASP655 4.6 228.0 1.0 SG A:CYS663 4.8 200.6 1.0 CG A:PHE656 4.8 210.2 1.0 N A:CYS654 4.8 224.7 1.0 O A:PHE656 4.9 210.2 1.0 N A:ASN657 4.9 226.6 1.0 CB A:CYS747 4.9 152.9 1.0 NE2 A:GLN664 4.9 188.7 1.0 CD2 A:PHE656 4.9 210.2 1.0 C A:CYS651 5.0 211.0 1.0

Iron binding site 3 out of 4 in the Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe2301 b:232.1 occ:1.00 FE3 A:SF42301 0.0 232.1 1.0 SG A:CYS747 2.3 152.9 1.0 S4 A:SF42301 2.3 232.1 1.0 S1 A:SF42301 2.3 232.1 1.0 S2 A:SF42301 2.3 232.1 1.0 CB A:CYS747 2.5 152.9 1.0 FE2 A:SF42301 2.7 232.1 1.0 FE4 A:SF42301 2.7 232.1 1.0 FE1 A:SF42301 2.7 232.1 1.0 CA A:CYS747 2.9 152.9 1.0 OE1 A:GLN748 3.3 152.7 1.0 S3 A:SF42301 3.9 232.1 1.0 N A:CYS747 3.9 152.9 1.0 N A:GLN748 3.9 152.7 1.0 C A:CYS747 4.0 152.9 1.0 CD A:GLN748 4.2 152.7 1.0 NE2 A:GLN748 4.4 152.7 1.0 O A:ILE746 4.5 155.5 1.0 SG A:CYS654 4.6 224.7 1.0 C A:ILE746 4.6 155.5 1.0 CG1 A:VAL646 4.6 161.9 1.0 O A:CYS663 4.8 200.6 1.0 CB A:CYS654 4.8 224.7 1.0 SG A:CYS663 4.9 200.6 1.0 SG A:CYS651 4.9 211.0 1.0

Iron binding site 4 out of 4 in the Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Human Polymerase Epsilon Bound to Pcna and Dna in the Nucleotide Exchange State within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe2301 b:232.1 occ:1.00 FE4 A:SF42301 0.0 232.1 1.0 SG A:CYS651 2.3 211.0 1.0 S3 A:SF42301 2.3 232.1 1.0 S1 A:SF42301 2.3 232.1 1.0 S2 A:SF42301 2.3 232.1 1.0 FE2 A:SF42301 2.7 232.1 1.0 FE1 A:SF42301 2.7 232.1 1.0 FE3 A:SF42301 2.7 232.1 1.0 CB A:CYS651 3.5 211.0 1.0 NE2 A:GLN664 3.6 188.7 1.0 O A:CYS651 3.8 211.0 1.0 S4 A:SF42301 3.9 232.1 1.0 CA A:CYS651 3.9 211.0 1.0 CG A:GLN664 4.0 188.7 1.0 CD A:GLN664 4.2 188.7 1.0 C A:CYS651 4.2 211.0 1.0 CG1 A:VAL646 4.5 161.9 1.0 CB A:CYS654 4.6 224.7 1.0 SG A:CYS663 4.7 200.6 1.0 CB A:CYS747 4.8 152.9 1.0 SG A:CYS654 4.9 224.7 1.0 SG A:CYS747 4.9 152.9 1.0 CA A:CYS747 5.0 152.9 1.0

F.Wang, Q.He, H.Li. The Nucleotide Exchange State of Human Polymerase Epsilon Bound to Dna and Pcna To Be Published.