Iron in PDB 9fso: Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1)

All present enzymatic activity of Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1):
2.7.7.6;

The structure of Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1) also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Zinc	(Zn)	9 atoms

The binding sites of Iron atom in the Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1) (pdb code 9fso). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1), PDB code: 9fso:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1) within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe401 b:93.5 occ:1.00 FE1 F:SF4401 0.0 93.5 1.0 SG F:CYS290 1.7 95.5 1.0 S3 F:SF4401 2.3 93.5 1.0 S4 F:SF4401 2.3 93.5 1.0 S2 F:SF4401 2.3 93.5 1.0 CB F:CYS290 2.4 95.5 1.0 FE4 F:SF4401 2.7 93.5 1.0 FE3 F:SF4401 2.7 93.5 1.0 FE2 F:SF4401 2.7 93.5 1.0 SG F:CYS307 3.5 97.3 1.0 SG F:CYS287 3.7 96.9 1.0 CA F:CYS290 3.9 95.5 1.0 S1 F:SF4401 3.9 93.5 1.0 SG F:CYS296 4.0 89.3 1.0 CA F:CYS287 4.1 96.9 1.0 O F:VAL292 4.2 91.1 1.0 CB F:CYS287 4.6 96.9 1.0 O F:CYS287 4.6 96.9 1.0 C F:CYS290 4.6 95.5 1.0 N F:CYS290 4.8 95.5 1.0 O F:CYS290 4.8 95.5 1.0 C F:CYS287 4.9 96.9 1.0 N F:CYS287 5.0 96.9 1.0

Iron binding site 2 out of 4 in the Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1) within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe401 b:93.5 occ:1.00 FE2 F:SF4401 0.0 93.5 1.0 SG F:CYS307 2.2 97.3 1.0 S1 F:SF4401 2.3 93.5 1.0 S3 F:SF4401 2.3 93.5 1.0 S4 F:SF4401 2.3 93.5 1.0 FE4 F:SF4401 2.7 93.5 1.0 FE3 F:SF4401 2.7 93.5 1.0 FE1 F:SF4401 2.7 93.5 1.0 CB F:CYS307 2.9 97.3 1.0 SG F:CYS287 3.8 96.9 1.0 SG F:CYS296 3.8 89.3 1.0 S2 F:SF4401 3.9 93.5 1.0 SG F:CYS290 3.9 95.5 1.0 CA F:PRO304 4.0 92.1 1.0 CE F:MET310 4.2 98.0 1.0 N F:PRO304 4.3 92.1 1.0 CA F:CYS307 4.3 97.3 1.0 ND2 C:ASN445 4.5 65.0 1.0 C F:SER303 4.6 91.8 1.0 O F:SER303 4.6 91.8 1.0 CB F:PRO304 4.7 92.1 1.0 CG F:MET310 4.8 98.0 1.0 CD F:PRO304 4.9 92.1 1.0 O F:PRO304 5.0 92.1 1.0 C F:PRO304 5.0 92.1 1.0

Iron binding site 3 out of 4 in the Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1) within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe401 b:93.5 occ:1.00 FE3 F:SF4401 0.0 93.5 1.0 SG F:CYS296 1.4 89.3 1.0 S2 F:SF4401 2.3 93.5 1.0 S4 F:SF4401 2.3 93.5 1.0 S1 F:SF4401 2.3 93.5 1.0 FE2 F:SF4401 2.7 93.5 1.0 FE4 F:SF4401 2.7 93.5 1.0 FE1 F:SF4401 2.7 93.5 1.0 CB F:CYS296 3.2 89.3 1.0 ND2 C:ASN445 3.3 65.0 1.0 S3 F:SF4401 3.9 93.5 1.0 SG F:CYS287 3.9 96.9 1.0 O F:CYS296 4.0 89.3 1.0 CA F:CYS296 4.2 89.3 1.0 O F:VAL292 4.2 91.1 1.0 SG F:CYS290 4.4 95.5 1.0 SG F:CYS307 4.6 97.3 1.0 CG C:ASN445 4.6 65.0 1.0 C F:CYS296 4.6 89.3 1.0 CD1 F:PHE293 4.8 91.2 1.0 CB F:CYS290 4.8 95.5 1.0

Iron binding site 4 out of 4 in the Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Human Rna Polymerase III Class III Open Pre-Initiation Complex 1 (OC1) within 5.0Å range: probe atom residue distance (Å) B Occ F:Fe401 b:93.5 occ:1.00 FE4 F:SF4401 0.0 93.5 1.0 SG F:CYS287 1.2 96.9 1.0 S1 F:SF4401 2.3 93.5 1.0 S3 F:SF4401 2.3 93.5 1.0 S2 F:SF4401 2.3 93.5 1.0 FE2 F:SF4401 2.7 93.5 1.0 FE1 F:SF4401 2.7 93.5 1.0 FE3 F:SF4401 2.7 93.5 1.0 CB F:CYS287 2.8 96.9 1.0 ND2 C:ASN445 3.1 65.0 1.0 CA F:CYS287 3.4 96.9 1.0 S4 F:SF4401 3.9 93.5 1.0 SG F:CYS296 4.0 89.3 1.0 CG C:ASN445 4.1 65.0 1.0 CB C:ASN445 4.1 65.0 1.0 SG F:CYS290 4.3 95.5 1.0 CB F:CYS290 4.3 95.5 1.0 N F:CYS287 4.3 96.9 1.0 CE F:MET310 4.4 98.0 1.0 C F:CYS287 4.5 96.9 1.0 SG F:CYS307 4.5 97.3 1.0 O F:CYS287 4.7 96.9 1.0

S.Z.Shah, T.N.Perry, A.Graziadei, V.Cecatiello, T.Kaliyappan, A.D.Misiaszek, C.W.Muller, E.P.Ramsay, A.Vannini. Structural Insights Into Distinct Mechanisms of Rna Polymerase II and III Recruitment to Snrna Promoters. Nat Commun V. 16 141 2025.
ISSN: ESSN 2041-1723
PubMed: 39747245
DOI: 10.1038/S41467-024-55553-8