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Iron in PDB 1gph: Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis

Enzymatic activity of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis

All present enzymatic activity of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis:
2.4.2.14;

Protein crystallography data

The structure of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis, PDB code: 1gph was solved by J.L.Smith, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 7.00 / 3.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 158.800, 75.700, 94.100, 90.00, 91.40, 90.00
R / Rfree (%) 18.2 / n/a

Iron Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 16;

Binding sites:

The binding sites of Iron atom in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis (pdb code 1gph). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 16 binding sites of Iron where determined in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis, PDB code: 1gph:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iron binding site 1 out of 16 in 1gph

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Iron binding site 1 out of 16 in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis within 5.0Å range:
probe atom residue distance (Å) B Occ
1:Fe466

b:19.2
occ:1.00
 FE1 1:SF4466 0.0 19.2 1.0
S3 1:SF4466 2.3 19.2 1.0
S2 1:SF4466 2.3 19.2 1.0
SG 1:CYS437 2.3 10.0 1.0
S4 1:SF4466 2.3 19.2 1.0
FE2 1:SF4466 2.5 19.2 1.0
FE3 1:SF4466 2.5 19.2 1.0
FE4 1:SF4466 2.6 19.2 1.0
CB 1:CYS437 3.4 10.0 1.0
S1 1:SF4466 3.8 19.2 1.0
O 1:CYS437 4.1 13.3 1.0
C 1:CYS437 4.2 13.3 1.0
CD2 1:TYR384 4.3 16.6 1.0
N 1:ALA439 4.3 14.6 1.0
CB 1:ALA439 4.4 10.8 1.0
SG 1:CYS440 4.4 13.5 1.0
CA 1:CYS437 4.5 13.3 1.0
SG 1:CYS236 4.6 10.0 1.0
CE2 1:TYR384 4.7 16.6 1.0
N 1:LEU438 4.7 11.2 1.0
CA 1:CYS236 4.7 14.4 1.0
SG 1:CYS382 4.7 11.3 1.0
N 1:CYS440 4.8 18.5 1.0
CA 1:ALA439 4.9 14.6 1.0
C 1:LEU438 4.9 11.2 1.0

Iron binding site 2 out of 16 in 1gph

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Iron binding site 2 out of 16 in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis within 5.0Å range:
probe atom residue distance (Å) B Occ
1:Fe466

b:19.2
occ:1.00
 FE2 1:SF4466 0.0 19.2 1.0
S1 1:SF4466 2.3 19.2 1.0
S3 1:SF4466 2.3 19.2 1.0
SG 1:CYS236 2.3 10.0 1.0
S4 1:SF4466 2.3 19.2 1.0
FE1 1:SF4466 2.5 19.2 1.0
FE4 1:SF4466 2.5 19.2 1.0
FE3 1:SF4466 2.6 19.2 1.0
CB 1:CYS236 3.3 10.0 1.0
CA 1:CYS236 3.6 14.4 1.0
S2 1:SF4466 3.8 19.2 1.0
N 1:SER237 4.1 15.2 1.0
C 1:CYS236 4.2 14.4 1.0
N 1:MET238 4.4 10.0 1.0
CG 1:MET238 4.4 10.0 1.0
CB 1:MET238 4.4 10.0 1.0
SG 1:CYS437 4.5 10.0 1.0
SG 1:CYS382 4.5 11.3 1.0
SG 1:CYS440 4.6 13.5 1.0
CG2 1:THR388 4.7 15.8 1.0
CB 1:THR388 4.8 15.8 1.0
N 1:CYS236 4.9 14.4 1.0
CB 1:CYS437 4.9 10.0 1.0

Iron binding site 3 out of 16 in 1gph

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Iron binding site 3 out of 16 in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis within 5.0Å range:
probe atom residue distance (Å) B Occ
1:Fe466

b:19.2
occ:1.00
 FE3 1:SF4466 0.0 19.2 1.0
S4 1:SF4466 2.2 19.2 1.0
SG 1:CYS440 2.3 13.5 1.0
S2 1:SF4466 2.3 19.2 1.0
S1 1:SF4466 2.3 19.2 1.0
FE4 1:SF4466 2.5 19.2 1.0
FE1 1:SF4466 2.5 19.2 1.0
FE2 1:SF4466 2.6 19.2 1.0
CB 1:CYS440 3.4 13.5 1.0
S3 1:SF4466 3.8 19.2 1.0
N 1:CYS440 4.0 18.5 1.0
CG 1:MET238 4.3 10.0 1.0
CA 1:CYS440 4.4 18.5 1.0
SG 1:CYS382 4.5 11.3 1.0
SG 1:CYS437 4.6 10.0 1.0
SG 1:CYS236 4.6 10.0 1.0
CB 1:CYS382 4.7 11.3 1.0
N 1:ALA439 5.0 14.6 1.0

Iron binding site 4 out of 16 in 1gph

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Iron binding site 4 out of 16 in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis within 5.0Å range:
probe atom residue distance (Å) B Occ
1:Fe466

b:19.2
occ:1.00
 FE4 1:SF4466 0.0 19.2 1.0
S1 1:SF4466 2.3 19.2 1.0
SG 1:CYS382 2.3 11.3 1.0
S3 1:SF4466 2.3 19.2 1.0
S2 1:SF4466 2.3 19.2 1.0
FE3 1:SF4466 2.5 19.2 1.0
FE2 1:SF4466 2.5 19.2 1.0
FE1 1:SF4466 2.6 19.2 1.0
CB 1:CYS382 3.2 11.3 1.0
S4 1:SF4466 3.8 19.2 1.0
CA 1:CYS382 4.0 17.9 1.0
CD2 1:TYR384 4.1 16.6 1.0
SG 1:CYS236 4.5 10.0 1.0
CB 1:TYR384 4.5 16.6 1.0
CB 1:THR388 4.5 15.8 1.0
SG 1:CYS440 4.6 13.5 1.0
OG1 1:THR388 4.6 15.8 1.0
SG 1:CYS437 4.7 10.0 1.0
CG 1:TYR384 4.8 16.6 1.0
O 1:THR388 4.9 27.4 1.0
C 1:CYS382 4.9 17.9 1.0
N 1:TYR384 4.9 19.8 1.0
CE2 1:TYR384 5.0 16.6 1.0

Iron binding site 5 out of 16 in 1gph

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Iron binding site 5 out of 16 in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis within 5.0Å range:
probe atom residue distance (Å) B Occ
2:Fe466

b:19.2
occ:1.00
 FE1 2:SF4466 0.0 19.2 1.0
S3 2:SF4466 2.3 19.2 1.0
S2 2:SF4466 2.3 19.2 1.0
SG 2:CYS437 2.3 10.0 1.0
S4 2:SF4466 2.3 19.2 1.0
FE2 2:SF4466 2.5 19.2 1.0
FE3 2:SF4466 2.6 19.2 1.0
FE4 2:SF4466 2.6 19.2 1.0
CB 2:CYS437 3.3 10.0 1.0
S1 2:SF4466 3.8 19.2 1.0
O 2:CYS437 4.1 13.3 1.0
CD2 2:TYR384 4.2 16.6 1.0
C 2:CYS437 4.2 13.3 1.0
CA 2:CYS437 4.4 13.3 1.0
N 2:ALA439 4.5 14.6 1.0
CE2 2:TYR384 4.5 16.6 1.0
SG 2:CYS236 4.6 10.0 1.0
SG 2:CYS440 4.6 13.5 1.0
CA 2:CYS236 4.6 14.4 1.0
SG 2:CYS382 4.7 11.3 1.0
CD2 2:LEU177 4.7 10.0 1.0
CB 2:ALA439 4.7 10.8 1.0
N 2:LEU438 4.7 11.2 1.0
N 2:CYS440 4.9 18.5 1.0
CB 2:CYS236 5.0 10.0 1.0

Iron binding site 6 out of 16 in 1gph

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Iron binding site 6 out of 16 in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis within 5.0Å range:
probe atom residue distance (Å) B Occ
2:Fe466

b:19.2
occ:1.00
 FE2 2:SF4466 0.0 19.2 1.0
S1 2:SF4466 2.2 19.2 1.0
S4 2:SF4466 2.3 19.2 1.0
SG 2:CYS236 2.3 10.0 1.0
S3 2:SF4466 2.3 19.2 1.0
FE4 2:SF4466 2.4 19.2 1.0
FE1 2:SF4466 2.5 19.2 1.0
FE3 2:SF4466 2.6 19.2 1.0
CB 2:CYS236 3.4 10.0 1.0
CA 2:CYS236 3.6 14.4 1.0
S2 2:SF4466 3.7 19.2 1.0
N 2:SER237 4.1 15.2 1.0
C 2:CYS236 4.1 14.4 1.0
SG 2:CYS382 4.5 11.3 1.0
CB 2:MET238 4.5 10.0 1.0
SG 2:CYS437 4.6 10.0 1.0
N 2:MET238 4.6 10.0 1.0
CG 2:MET238 4.7 10.0 1.0
SG 2:CYS440 4.7 13.5 1.0
CB 2:THR388 4.7 15.8 1.0
CG2 2:THR388 4.8 15.8 1.0
CB 2:CYS437 4.8 10.0 1.0
OG1 2:THR388 4.9 15.8 1.0
N 2:CYS236 4.9 14.4 1.0
O 2:CYS437 5.0 13.3 1.0

Iron binding site 7 out of 16 in 1gph

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Iron binding site 7 out of 16 in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis within 5.0Å range:
probe atom residue distance (Å) B Occ
2:Fe466

b:19.2
occ:1.00
 FE3 2:SF4466 0.0 19.2 1.0
S1 2:SF4466 2.3 19.2 1.0
S4 2:SF4466 2.3 19.2 1.0
SG 2:CYS440 2.3 13.5 1.0
S2 2:SF4466 2.3 19.2 1.0
FE4 2:SF4466 2.6 19.2 1.0
FE1 2:SF4466 2.6 19.2 1.0
FE2 2:SF4466 2.6 19.2 1.0
CB 2:CYS440 3.4 13.5 1.0
S3 2:SF4466 3.9 19.2 1.0
N 2:CYS440 4.0 18.5 1.0
CA 2:CYS440 4.4 18.5 1.0
CG 2:MET238 4.4 10.0 1.0
SG 2:CYS437 4.5 10.0 1.0
SG 2:CYS382 4.6 11.3 1.0
SG 2:CYS236 4.6 10.0 1.0
O 2:CYS437 4.8 13.3 1.0
CB 2:CYS382 4.8 11.3 1.0
N 2:ALA439 4.9 14.6 1.0

Iron binding site 8 out of 16 in 1gph

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Iron binding site 8 out of 16 in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis within 5.0Å range:
probe atom residue distance (Å) B Occ
2:Fe466

b:19.2
occ:1.00
 FE4 2:SF4466 0.0 19.2 1.0
S3 2:SF4466 2.3 19.2 1.0
SG 2:CYS382 2.3 11.3 1.0
S2 2:SF4466 2.3 19.2 1.0
S1 2:SF4466 2.3 19.2 1.0
FE2 2:SF4466 2.4 19.2 1.0
FE3 2:SF4466 2.6 19.2 1.0
FE1 2:SF4466 2.6 19.2 1.0
CB 2:CYS382 3.3 11.3 1.0
S4 2:SF4466 3.8 19.2 1.0
CA 2:CYS382 4.0 17.9 1.0
OG1 2:THR388 4.1 15.8 1.0
CD2 2:TYR384 4.1 16.6 1.0
CB 2:THR388 4.4 15.8 1.0
SG 2:CYS236 4.5 10.0 1.0
SG 2:CYS440 4.6 13.5 1.0
O 2:THR388 4.6 27.4 1.0
CB 2:TYR384 4.7 16.6 1.0
SG 2:CYS437 4.7 10.0 1.0
CG 2:TYR384 4.9 16.6 1.0
CE2 2:TYR384 4.9 16.6 1.0
C 2:CYS382 5.0 17.9 1.0

Iron binding site 9 out of 16 in 1gph

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Iron binding site 9 out of 16 in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 9 of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis within 5.0Å range:
probe atom residue distance (Å) B Occ
3:Fe466

b:19.2
occ:1.00
 FE1 3:SF4466 0.0 19.2 1.0
S2 3:SF4466 2.3 19.2 1.0
S3 3:SF4466 2.3 19.2 1.0
S4 3:SF4466 2.3 19.2 1.0
SG 3:CYS437 2.3 10.0 1.0
FE2 3:SF4466 2.5 19.2 1.0
FE3 3:SF4466 2.6 19.2 1.0
FE4 3:SF4466 2.7 19.2 1.0
CB 3:CYS437 3.3 10.0 1.0
O 3:CYS437 3.8 13.3 1.0
S1 3:SF4466 3.9 19.2 1.0
C 3:CYS437 4.1 13.3 1.0
CA 3:CYS437 4.3 13.3 1.0
N 3:ALA439 4.4 14.6 1.0
CD2 3:TYR384 4.5 16.6 1.0
SG 3:CYS440 4.5 13.5 1.0
CB 3:ALA439 4.5 10.8 1.0
SG 3:CYS236 4.5 10.0 1.0
CA 3:CYS236 4.6 14.4 1.0
SG 3:CYS382 4.7 11.3 1.0
N 3:CYS440 4.8 18.5 1.0
N 3:LEU438 4.8 11.2 1.0
CB 3:CYS236 5.0 10.0 1.0
N 3:SER237 5.0 15.2 1.0
CE2 3:TYR384 5.0 16.6 1.0
CA 3:ALA439 5.0 14.6 1.0

Iron binding site 10 out of 16 in 1gph

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Iron binding site 10 out of 16 in the Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 10 of Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis within 5.0Å range:
probe atom residue distance (Å) B Occ
3:Fe466

b:19.2
occ:1.00
 FE2 3:SF4466 0.0 19.2 1.0
S1 3:SF4466 2.2 19.2 1.0
S3 3:SF4466 2.3 19.2 1.0
SG 3:CYS236 2.3 10.0 1.0
S4 3:SF4466 2.3 19.2 1.0
FE4 3:SF4466 2.4 19.2 1.0
FE1 3:SF4466 2.5 19.2 1.0
FE3 3:SF4466 2.6 19.2 1.0
CB 3:CYS236 3.4 10.0 1.0
CA 3:CYS236 3.6 14.4 1.0
S2 3:SF4466 3.7 19.2 1.0
N 3:SER237 4.2 15.2 1.0
C 3:CYS236 4.3 14.4 1.0
N 3:MET238 4.4 10.0 1.0
SG 3:CYS382 4.4 11.3 1.0
CB 3:MET238 4.4 10.0 1.0
SG 3:CYS437 4.6 10.0 1.0
CG2 3:THR388 4.6 15.8 1.0
CB 3:THR388 4.6 15.8 1.0
CG 3:MET238 4.7 10.0 1.0
SG 3:CYS440 4.8 13.5 1.0
O 3:CYS437 4.9 13.3 1.0
N 3:CYS236 4.9 14.4 1.0
CB 3:CYS437 4.9 10.0 1.0
OG1 3:THR388 5.0 15.8 1.0

Reference:

J.L.Smith, E.J.Zaluzec, J.P.Wery, L.Niu, R.L.Switzer, H.Zalkin, Y.Satow. Structure of the Allosteric Regulatory Enzyme of Purine Biosynthesis. Science V. 264 1427 1994.
ISSN: ISSN 0036-8075
PubMed: 8197456
Page generated: Wed Jul 16 15:03:11 2025

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