Atomistry » Iron » PDB 1qov-1ra5 » 1r35
Atomistry »
  Iron »
    PDB 1qov-1ra5 »
      1r35 »

Iron in PDB 1r35: Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine

Enzymatic activity of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine

All present enzymatic activity of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine:
1.14.13.39;

Protein crystallography data

The structure of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine, PDB code: 1r35 was solved by H.S.Shieh, A.M.Stevens, W.C.Stallings, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.30
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 214.280, 214.280, 117.130, 90.00, 90.00, 120.00
R / Rfree (%) 25.2 / 28.5

Other elements in 1r35:

The structure of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine also contains other interesting chemical elements:

Fluorine (F) 2 atoms

Iron Binding Sites:

The binding sites of Iron atom in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine (pdb code 1r35). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine, PDB code: 1r35:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in 1r35

Go back to Iron Binding Sites List in 1r35
Iron binding site 1 out of 2 in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe901

b:29.6
occ:1.00
 FE A:HEM901 0.0 29.6 1.0
ND A:HEM901 2.0 44.4 1.0
NA A:HEM901 2.0 43.1 1.0
NC A:HEM901 2.0 45.4 1.0
NB A:HEM901 2.0 40.9 1.0
SG A:CYS194 2.3 37.6 1.0
C1D A:HEM901 3.0 43.2 1.0
C4A A:HEM901 3.0 38.2 1.0
C4C A:HEM901 3.0 44.6 1.0
C1B A:HEM901 3.1 38.5 1.0
C1C A:HEM901 3.1 43.4 1.0
C1A A:HEM901 3.1 42.1 1.0
C4D A:HEM901 3.1 45.1 1.0
C4B A:HEM901 3.1 40.0 1.0
CB A:CYS194 3.2 37.8 1.0
CHD A:HEM901 3.4 39.5 1.0
CHB A:HEM901 3.4 37.7 1.0
CHC A:HEM901 3.5 40.6 1.0
CHA A:HEM901 3.5 41.2 1.0
CA A:CYS194 4.1 37.7 1.0
CT A:I58800 4.2 42.7 1.0
C2D A:HEM901 4.3 41.3 1.0
C3A A:HEM901 4.3 42.0 1.0
C2B A:HEM901 4.3 40.9 1.0
C3C A:HEM901 4.3 43.7 1.0
C3D A:HEM901 4.3 42.7 1.0
C2C A:HEM901 4.3 45.5 1.0
C2A A:HEM901 4.3 36.5 1.0
C3B A:HEM901 4.3 39.2 1.0
NE1 A:TRP188 4.4 37.6 1.0
CX A:I58800 4.6 53.0 1.0
CE A:I58800 4.8 45.6 1.0
N A:GLY196 4.8 37.2 1.0
C A:CYS194 4.8 38.1 1.0
N A:ILE195 5.0 38.4 1.0

Iron binding site 2 out of 2 in 1r35

Go back to Iron Binding Sites List in 1r35
Iron binding site 2 out of 2 in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe901

b:37.9
occ:1.00
 FE B:HEM901 0.0 37.9 1.0
ND B:HEM901 2.0 42.2 1.0
NA B:HEM901 2.0 39.4 1.0
NC B:HEM901 2.0 45.6 1.0
NB B:HEM901 2.0 37.7 1.0
SG B:CYS194 2.6 41.7 1.0
C1D B:HEM901 3.0 40.6 1.0
C4A B:HEM901 3.0 36.4 1.0
C4C B:HEM901 3.0 43.9 1.0
C1B B:HEM901 3.1 38.0 1.0
C4D B:HEM901 3.1 42.5 1.0
C1A B:HEM901 3.1 39.1 1.0
C1C B:HEM901 3.1 44.5 1.0
C4B B:HEM901 3.1 38.8 1.0
CB B:CYS194 3.3 39.5 1.0
CHD B:HEM901 3.4 38.8 1.0
CHB B:HEM901 3.4 36.6 1.0
CHA B:HEM901 3.4 38.3 1.0
CHC B:HEM901 3.5 42.3 1.0
CT B:I581800 4.1 45.5 1.0
CA B:CYS194 4.2 37.1 1.0
C2D B:HEM901 4.2 40.2 1.0
C3A B:HEM901 4.3 40.0 1.0
C3D B:HEM901 4.3 42.5 1.0
C2A B:HEM901 4.3 32.3 1.0
C3C B:HEM901 4.3 44.6 1.0
C2B B:HEM901 4.3 40.9 1.0
C2C B:HEM901 4.3 46.4 1.0
C3B B:HEM901 4.4 39.3 1.0
NE1 B:TRP188 4.4 36.6 1.0
CX B:I581800 4.6 50.3 1.0
CE B:I581800 4.7 44.8 1.0
N B:GLY196 4.8 40.7 1.0
C B:CYS194 4.9 38.5 1.0

Reference:

E.A.Hallinan, S.W.Kramer, S.C.Houdek, W.M.Moore, G.M.Jerome, D.P.Spangler, A.M.Stevens, H.S.Shieh, P.T.Manning, B.S.Pitzele. 4-Fluorinated L-Lysine Analogs As Selective I-Nos Inhibitors: Methodology For Introducing Fluorine Into the Lysine Side Chain. Org.Biomol.Chem. V. 1 3527 2003.
ISSN: ISSN 1477-0520
PubMed: 14599013
DOI: 10.1039/B307563J
Page generated: Sat Aug 3 13:59:49 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy