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Iron in PDB 2vn0: CYP2C8DH Complexed with Troglitazone

Enzymatic activity of CYP2C8DH Complexed with Troglitazone

All present enzymatic activity of CYP2C8DH Complexed with Troglitazone:
1.14.14.1;

Protein crystallography data

The structure of CYP2C8DH Complexed with Troglitazone, PDB code: 2vn0 was solved by G.A.Schoch, J.K.Yano, S.Sansen, C.D.Stout, E.F.Johnson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.88 / 2.70
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 74.200, 136.090, 163.240, 90.00, 90.00, 90.00
R / Rfree (%) 21.8 / 25.4

Iron Binding Sites:

The binding sites of Iron atom in the CYP2C8DH Complexed with Troglitazone (pdb code 2vn0). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the CYP2C8DH Complexed with Troglitazone, PDB code: 2vn0:

Iron binding site 1 out of 1 in 2vn0

Go back to Iron Binding Sites List in 2vn0
Iron binding site 1 out of 1 in the CYP2C8DH Complexed with Troglitazone


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of CYP2C8DH Complexed with Troglitazone within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe500

b:42.2
occ:1.00
FE A:HEM500 0.0 42.2 1.0
NC A:HEM500 2.0 43.8 1.0
NA A:HEM500 2.0 44.1 1.0
NB A:HEM500 2.1 42.0 1.0
ND A:HEM500 2.1 45.1 1.0
SG A:CYS435 2.3 44.7 1.0
C1C A:HEM500 3.0 42.8 1.0
C4B A:HEM500 3.0 41.5 1.0
C4A A:HEM500 3.0 44.7 1.0
C1D A:HEM500 3.0 46.0 1.0
C1B A:HEM500 3.0 40.5 1.0
C4C A:HEM500 3.0 44.4 1.0
C1A A:HEM500 3.1 45.4 1.0
C4D A:HEM500 3.1 45.6 1.0
CHC A:HEM500 3.3 40.6 1.0
CHB A:HEM500 3.3 42.7 1.0
CHD A:HEM500 3.3 45.2 1.0
CHA A:HEM500 3.4 45.2 1.0
CB A:CYS435 3.6 42.6 1.0
O A:ALA297 3.6 51.8 1.0
C2C A:HEM500 4.2 44.0 1.0
C3A A:HEM500 4.2 44.5 1.0
C2D A:HEM500 4.2 46.2 1.0
C3B A:HEM500 4.3 38.7 1.0
C2A A:HEM500 4.3 45.7 1.0
C3C A:HEM500 4.3 44.9 1.0
CA A:CYS435 4.3 42.6 1.0
C2B A:HEM500 4.3 38.4 1.0
C3D A:HEM500 4.3 46.2 1.0
C A:ALA297 4.5 49.4 1.0
CB A:ALA297 4.6 45.8 1.0
N A:ALA436 4.8 43.5 1.0
N A:GLY437 4.9 41.9 1.0
C A:CYS435 4.9 43.3 1.0
CA A:ALA297 5.0 47.8 1.0

Reference:

G.A.Schoch, J.K.Yano, S.Sansen, P.M.Dansette, C.D.Stout, E.F.Johnson. Determinants of Cytochrome P450 2C8 Substrate Binding: Structures of Complexes with Montelukast, Troglitazone, Felodipine, and 9-Cis-Retinoic Acid. J. Biol. Chem. V. 283 17227 2008.
ISSN: ISSN 0021-9258
PubMed: 18413310
DOI: 10.1074/JBC.M802180200
Page generated: Thu Jul 17 04:28:00 2025

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