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Iron in PDB 2zbx: Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (Wild Type) with Imidazole Bound

Enzymatic activity of Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (Wild Type) with Imidazole Bound

All present enzymatic activity of Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (Wild Type) with Imidazole Bound:
1.14.14.1;

Protein crystallography data

The structure of Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (Wild Type) with Imidazole Bound, PDB code: 2zbx was solved by H.Sugimoto, R.Shinkyo, K.Hayashi, S.Yoneda, M.Yamada, M.Kamakura, S.Ikushiro, Y.Shiro, T.Sakaki, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.62 / 1.50
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 52.575, 53.754, 140.948, 90.00, 90.00, 90.00
R / Rfree (%) 19.4 / 22.3

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (Wild Type) with Imidazole Bound (pdb code 2zbx). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (Wild Type) with Imidazole Bound, PDB code: 2zbx:

Iron binding site 1 out of 1 in 2zbx

Go back to Iron Binding Sites List in 2zbx
Iron binding site 1 out of 1 in the Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (Wild Type) with Imidazole Bound


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (Wild Type) with Imidazole Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe413

b:11.5
occ:1.00
 FE A:HEM413 0.0 11.5 1.0
NB A:HEM413 2.0 9.7 1.0
ND A:HEM413 2.0 10.4 1.0
NA A:HEM413 2.0 10.4 1.0
NC A:HEM413 2.1 10.3 1.0
N1 A:IMD501 2.1 23.2 1.0
SG A:CYS355 2.4 11.3 1.0
C4B A:HEM413 3.0 10.9 1.0
C1C A:HEM413 3.1 11.0 1.0
C4D A:HEM413 3.1 11.6 1.0
C1A A:HEM413 3.1 11.6 1.0
C1B A:HEM413 3.1 10.4 1.0
C4A A:HEM413 3.1 10.0 1.0
C1D A:HEM413 3.1 11.3 1.0
C4C A:HEM413 3.1 11.3 1.0
C5 A:IMD501 3.1 23.6 1.0
C2 A:IMD501 3.1 22.9 1.0
CB A:CYS355 3.4 9.2 1.0
CHC A:HEM413 3.4 11.7 1.0
CHA A:HEM413 3.4 11.7 1.0
CHB A:HEM413 3.4 9.5 1.0
CHD A:HEM413 3.5 11.4 1.0
CA A:CYS355 4.1 9.7 1.0
C3B A:HEM413 4.3 10.5 1.0
C2B A:HEM413 4.3 11.4 1.0
C2C A:HEM413 4.3 11.6 1.0
C2A A:HEM413 4.3 11.5 1.0
C3A A:HEM413 4.3 10.7 1.0
N3 A:IMD501 4.3 23.9 1.0
C4 A:IMD501 4.3 22.9 1.0
C3D A:HEM413 4.3 13.4 1.0
C2D A:HEM413 4.3 12.8 1.0
C3C A:HEM413 4.3 12.8 1.0
C A:CYS355 4.8 9.8 1.0
N A:GLY357 4.8 10.6 1.0
N A:LEU356 4.9 10.9 1.0
CB A:ALA244 4.9 15.0 1.0

Reference:

H.Sugimoto, R.Shinkyo, K.Hayashi, S.Yoneda, M.Yamada, M.Kamakura, S.Ikushiro, Y.Shiro, T.Sakaki. Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1ALPHA,25-Dihydroxyvitamin D3 Biochemistry V. 47 4017 2008.
ISSN: ISSN 0006-2960
PubMed: 18314962
DOI: 10.1021/BI7023767
Page generated: Mon Aug 4 22:44:22 2025

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