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Iron in PDB 2zbz: Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (R84A Mutant) in Complex with 1,25-Dihydroxyvitamin D3

Enzymatic activity of Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (R84A Mutant) in Complex with 1,25-Dihydroxyvitamin D3

All present enzymatic activity of Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (R84A Mutant) in Complex with 1,25-Dihydroxyvitamin D3:
1.14.14.1;

Protein crystallography data

The structure of Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (R84A Mutant) in Complex with 1,25-Dihydroxyvitamin D3, PDB code: 2zbz was solved by H.Sugimoto, R.Shinkyo, K.Hayashi, S.Yoneda, M.Yamada, M.Kamakura, S.Ikushiro, Y.Shiro, T.Sakaki, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.74 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 53.152, 53.671, 138.881, 90.00, 90.00, 90.00
R / Rfree (%) 19.8 / 24.2

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (R84A Mutant) in Complex with 1,25-Dihydroxyvitamin D3 (pdb code 2zbz). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (R84A Mutant) in Complex with 1,25-Dihydroxyvitamin D3, PDB code: 2zbz:

Iron binding site 1 out of 1 in 2zbz

Go back to Iron Binding Sites List in 2zbz
Iron binding site 1 out of 1 in the Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (R84A Mutant) in Complex with 1,25-Dihydroxyvitamin D3


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Vitamin D Hydroxylase Cytochrome P450 105A1 (R84A Mutant) in Complex with 1,25-Dihydroxyvitamin D3 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe413

b:9.7
occ:1.00
 FE A:HEM413 0.0 9.7 1.0
NB A:HEM413 2.1 9.3 1.0
NC A:HEM413 2.1 8.6 1.0
NA A:HEM413 2.1 9.0 1.0
ND A:HEM413 2.1 9.3 1.0
SG A:CYS355 2.4 9.2 1.0
C1B A:HEM413 3.1 9.3 1.0
C4B A:HEM413 3.1 9.7 1.0
C1C A:HEM413 3.1 9.2 1.0
C4A A:HEM413 3.1 8.7 1.0
C4D A:HEM413 3.1 8.6 1.0
C4C A:HEM413 3.1 8.8 1.0
C1A A:HEM413 3.1 9.0 1.0
C1D A:HEM413 3.1 9.0 1.0
CB A:CYS355 3.3 9.4 1.0
CHC A:HEM413 3.4 9.6 1.0
CHB A:HEM413 3.4 9.1 1.0
CHA A:HEM413 3.5 8.6 1.0
CHD A:HEM413 3.5 9.3 1.0
CA A:CYS355 4.0 9.7 1.0
C2B A:HEM413 4.3 9.3 1.0
C3B A:HEM413 4.3 10.3 1.0
C2C A:HEM413 4.3 8.6 1.0
C3C A:HEM413 4.3 9.4 1.0
C3A A:HEM413 4.3 8.6 1.0
C2A A:HEM413 4.3 8.5 1.0
C3D A:HEM413 4.3 9.1 1.0
C2D A:HEM413 4.4 9.1 1.0
C A:CYS355 4.7 10.1 1.0
N A:LEU356 4.7 10.6 1.0
N A:GLY357 4.7 10.4 1.0
O A:HOH789 4.7 40.8 1.0
CD1 A:PHE348 4.9 9.3 1.0

Reference:

H.Sugimoto, R.Shinkyo, K.Hayashi, S.Yoneda, M.Yamada, M.Kamakura, S.Ikushiro, Y.Shiro, T.Sakaki. Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1ALPHA,25-Dihydroxyvitamin D3 Biochemistry V. 47 4017 2008.
ISSN: ISSN 0006-2960
PubMed: 18314962
DOI: 10.1021/BI7023767
Page generated: Mon Aug 4 22:45:05 2025

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