Iron in PDB 3ben: Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3
Enzymatic activity of Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3
All present enzymatic activity of Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3:
1.14.14.1;
Protein crystallography data
The structure of Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3, PDB code: 3ben
was solved by
D.R.Tomchick,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
30.00 /
1.65
|
|
Space group
|
P 1 21 1
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
58.820,
148.209,
63.792,
90.00,
98.32,
90.00
|
|
R / Rfree (%)
|
16.1 /
19.1
|
Other elements in 3ben:
The structure of Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3 also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3
(pdb code 3ben). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the
Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3, PDB code: 3ben:
Jump to Iron binding site number:
1;
2;
3;
4;
Iron binding site 1 out
of 4 in 3ben
Go back to
Iron Binding Sites List in 3ben
Iron binding site 1 out
of 4 in the Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe470
b:12.3
occ:0.50
|
FE
|
A:HEM470
|
0.0
|
12.3
|
0.5
|
|
FE
|
A:HEM470
|
0.4
|
10.2
|
0.5
|
|
NC
|
A:HEM470
|
1.8
|
8.9
|
0.5
|
|
ND
|
A:HEM470
|
2.0
|
10.4
|
0.5
|
|
NC
|
A:HEM470
|
2.0
|
13.1
|
0.5
|
|
NB
|
A:HEM470
|
2.0
|
11.3
|
0.5
|
|
NA
|
A:HEM470
|
2.1
|
12.9
|
0.5
|
|
ND
|
A:HEM470
|
2.1
|
12.4
|
0.5
|
|
SG
|
A:CYS400
|
2.1
|
8.9
|
1.0
|
|
NB
|
A:HEM470
|
2.2
|
10.6
|
0.5
|
|
NA
|
A:HEM470
|
2.3
|
10.8
|
0.5
|
|
N3
|
A:LEH500
|
2.3
|
15.6
|
1.0
|
|
C4C
|
A:HEM470
|
2.8
|
9.0
|
0.5
|
|
C1D
|
A:HEM470
|
2.9
|
9.6
|
0.5
|
|
C1C
|
A:HEM470
|
2.9
|
9.3
|
0.5
|
|
C4B
|
A:HEM470
|
3.0
|
12.2
|
0.5
|
|
C1C
|
A:HEM470
|
3.0
|
12.5
|
0.5
|
|
C4C
|
A:HEM470
|
3.1
|
12.4
|
0.5
|
|
C1D
|
A:HEM470
|
3.1
|
12.3
|
0.5
|
|
C1B
|
A:HEM470
|
3.1
|
11.4
|
0.5
|
|
C1A
|
A:HEM470
|
3.1
|
11.2
|
0.5
|
|
C4A
|
A:HEM470
|
3.1
|
11.5
|
0.5
|
|
C4D
|
A:HEM470
|
3.1
|
11.4
|
0.5
|
|
C4B
|
A:HEM470
|
3.1
|
9.9
|
0.5
|
|
C4D
|
A:HEM470
|
3.1
|
9.0
|
0.5
|
|
CHD
|
A:HEM470
|
3.1
|
9.2
|
0.5
|
|
C21
|
A:LEH500
|
3.2
|
19.8
|
1.0
|
|
CB
|
A:CYS400
|
3.2
|
6.9
|
1.0
|
|
C1B
|
A:HEM470
|
3.3
|
10.2
|
0.5
|
|
C1A
|
A:HEM470
|
3.3
|
9.1
|
0.5
|
|
C19
|
A:LEH500
|
3.3
|
21.7
|
1.0
|
|
C4A
|
A:HEM470
|
3.3
|
11.0
|
0.5
|
|
CHC
|
A:HEM470
|
3.4
|
10.2
|
0.5
|
|
CHC
|
A:HEM470
|
3.4
|
12.4
|
0.5
|
|
CHD
|
A:HEM470
|
3.4
|
12.5
|
0.5
|
|
CHA
|
A:HEM470
|
3.5
|
11.6
|
0.5
|
|
CHB
|
A:HEM470
|
3.5
|
11.4
|
0.5
|
|
CHA
|
A:HEM470
|
3.6
|
9.2
|
0.5
|
|
CHB
|
A:HEM470
|
3.7
|
10.2
|
0.5
|
|
CA
|
A:CYS400
|
3.9
|
6.5
|
1.0
|
|
C3C
|
A:HEM470
|
4.0
|
9.6
|
0.5
|
|
C2C
|
A:HEM470
|
4.1
|
8.9
|
0.5
|
|
C2D
|
A:HEM470
|
4.1
|
9.1
|
0.5
|
|
C3B
|
A:HEM470
|
4.2
|
12.0
|
0.5
|
|
C2C
|
A:HEM470
|
4.3
|
12.7
|
0.5
|
|
C2B
|
A:HEM470
|
4.3
|
11.7
|
0.5
|
|
C20
|
A:LEH500
|
4.3
|
21.9
|
1.0
|
|
C3D
|
A:HEM470
|
4.3
|
9.4
|
0.5
|
|
C3C
|
A:HEM470
|
4.3
|
12.4
|
0.5
|
|
C3A
|
A:HEM470
|
4.3
|
11.4
|
0.5
|
|
C2A
|
A:HEM470
|
4.3
|
11.8
|
0.5
|
|
C2D
|
A:HEM470
|
4.3
|
11.4
|
0.5
|
|
C3D
|
A:HEM470
|
4.3
|
10.5
|
0.5
|
|
N2
|
A:LEH500
|
4.3
|
20.6
|
1.0
|
|
C3B
|
A:HEM470
|
4.4
|
10.9
|
0.5
|
|
C2B
|
A:HEM470
|
4.4
|
9.7
|
0.5
|
|
C2A
|
A:HEM470
|
4.5
|
9.0
|
0.5
|
|
C3A
|
A:HEM470
|
4.5
|
9.7
|
0.5
|
|
C
|
A:CYS400
|
4.7
|
8.4
|
1.0
|
|
N
|
A:GLY402
|
4.8
|
7.5
|
1.0
|
|
N
|
A:ILE401
|
4.9
|
7.7
|
1.0
|
|
Iron binding site 2 out
of 4 in 3ben
Go back to
Iron Binding Sites List in 3ben
Iron binding site 2 out
of 4 in the Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe470
b:10.2
occ:0.50
|
FE
|
A:HEM470
|
0.0
|
10.2
|
0.5
|
|
FE
|
A:HEM470
|
0.4
|
12.3
|
0.5
|
|
ND
|
A:HEM470
|
1.8
|
12.4
|
0.5
|
|
NC
|
A:HEM470
|
1.9
|
13.1
|
0.5
|
|
NC
|
A:HEM470
|
2.0
|
8.9
|
0.5
|
|
NB
|
A:HEM470
|
2.0
|
10.6
|
0.5
|
|
ND
|
A:HEM470
|
2.0
|
10.4
|
0.5
|
|
NA
|
A:HEM470
|
2.0
|
10.8
|
0.5
|
|
N3
|
A:LEH500
|
2.1
|
15.6
|
1.0
|
|
NA
|
A:HEM470
|
2.2
|
12.9
|
0.5
|
|
NB
|
A:HEM470
|
2.3
|
11.3
|
0.5
|
|
SG
|
A:CYS400
|
2.4
|
8.9
|
1.0
|
|
C1D
|
A:HEM470
|
2.8
|
12.3
|
0.5
|
|
C4C
|
A:HEM470
|
2.9
|
12.4
|
0.5
|
|
C4D
|
A:HEM470
|
2.9
|
11.4
|
0.5
|
|
C19
|
A:LEH500
|
3.0
|
21.7
|
1.0
|
|
C4C
|
A:HEM470
|
3.0
|
9.0
|
0.5
|
|
C21
|
A:LEH500
|
3.0
|
19.8
|
1.0
|
|
C1C
|
A:HEM470
|
3.0
|
12.5
|
0.5
|
|
C1D
|
A:HEM470
|
3.0
|
9.6
|
0.5
|
|
C4B
|
A:HEM470
|
3.1
|
9.9
|
0.5
|
|
C1B
|
A:HEM470
|
3.1
|
10.2
|
0.5
|
|
C4A
|
A:HEM470
|
3.1
|
11.0
|
0.5
|
|
C1A
|
A:HEM470
|
3.1
|
9.1
|
0.5
|
|
C1C
|
A:HEM470
|
3.1
|
9.3
|
0.5
|
|
C4D
|
A:HEM470
|
3.1
|
9.0
|
0.5
|
|
C1A
|
A:HEM470
|
3.1
|
11.2
|
0.5
|
|
CHD
|
A:HEM470
|
3.2
|
12.5
|
0.5
|
|
C4B
|
A:HEM470
|
3.2
|
12.2
|
0.5
|
|
C4A
|
A:HEM470
|
3.3
|
11.5
|
0.5
|
|
C1B
|
A:HEM470
|
3.3
|
11.4
|
0.5
|
|
CHD
|
A:HEM470
|
3.4
|
9.2
|
0.5
|
|
CHA
|
A:HEM470
|
3.4
|
11.6
|
0.5
|
|
CHB
|
A:HEM470
|
3.4
|
10.2
|
0.5
|
|
CB
|
A:CYS400
|
3.5
|
6.9
|
1.0
|
|
CHC
|
A:HEM470
|
3.5
|
10.2
|
0.5
|
|
CHA
|
A:HEM470
|
3.5
|
9.2
|
0.5
|
|
CHC
|
A:HEM470
|
3.5
|
12.4
|
0.5
|
|
CHB
|
A:HEM470
|
3.7
|
11.4
|
0.5
|
|
C20
|
A:LEH500
|
4.1
|
21.9
|
1.0
|
|
N2
|
A:LEH500
|
4.1
|
20.6
|
1.0
|
|
C2D
|
A:HEM470
|
4.1
|
11.4
|
0.5
|
|
CA
|
A:CYS400
|
4.1
|
6.5
|
1.0
|
|
C3D
|
A:HEM470
|
4.1
|
10.5
|
0.5
|
|
C3C
|
A:HEM470
|
4.2
|
12.4
|
0.5
|
|
C2C
|
A:HEM470
|
4.2
|
12.7
|
0.5
|
|
C3C
|
A:HEM470
|
4.2
|
9.6
|
0.5
|
|
C2C
|
A:HEM470
|
4.3
|
8.9
|
0.5
|
|
C2D
|
A:HEM470
|
4.3
|
9.1
|
0.5
|
|
C3B
|
A:HEM470
|
4.3
|
10.9
|
0.5
|
|
C2A
|
A:HEM470
|
4.3
|
9.0
|
0.5
|
|
C3A
|
A:HEM470
|
4.3
|
9.7
|
0.5
|
|
C2B
|
A:HEM470
|
4.3
|
9.7
|
0.5
|
|
C3D
|
A:HEM470
|
4.3
|
9.4
|
0.5
|
|
C2A
|
A:HEM470
|
4.4
|
11.8
|
0.5
|
|
C3A
|
A:HEM470
|
4.4
|
11.4
|
0.5
|
|
C3B
|
A:HEM470
|
4.5
|
12.0
|
0.5
|
|
C2B
|
A:HEM470
|
4.5
|
11.7
|
0.5
|
|
CB
|
A:ALA264
|
4.8
|
15.1
|
1.0
|
|
N
|
A:GLY402
|
4.8
|
7.5
|
1.0
|
|
C
|
A:CYS400
|
4.8
|
8.4
|
1.0
|
|
N
|
A:ILE401
|
4.9
|
7.7
|
1.0
|
|
Iron binding site 3 out
of 4 in 3ben
Go back to
Iron Binding Sites List in 3ben
Iron binding site 3 out
of 4 in the Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Fe471
b:12.3
occ:0.50
|
FE
|
B:HEM471
|
0.0
|
12.3
|
0.5
|
|
FE
|
B:HEM471
|
0.3
|
12.1
|
0.5
|
|
NC
|
B:HEM471
|
1.9
|
13.0
|
0.5
|
|
NB
|
B:HEM471
|
2.0
|
12.2
|
0.5
|
|
NB
|
B:HEM471
|
2.0
|
12.2
|
0.5
|
|
NA
|
B:HEM471
|
2.0
|
12.4
|
0.5
|
|
ND
|
B:HEM471
|
2.1
|
12.6
|
0.5
|
|
NC
|
B:HEM471
|
2.1
|
12.2
|
0.5
|
|
ND
|
B:HEM471
|
2.1
|
12.3
|
0.5
|
|
SG
|
B:CYS400
|
2.1
|
9.1
|
1.0
|
|
NA
|
B:HEM471
|
2.2
|
13.0
|
0.5
|
|
N3
|
B:LEH500
|
2.4
|
18.0
|
1.0
|
|
C1C
|
B:HEM471
|
2.9
|
11.3
|
0.5
|
|
C4C
|
B:HEM471
|
3.0
|
12.6
|
0.5
|
|
C4B
|
B:HEM471
|
3.0
|
12.0
|
0.5
|
|
C1B
|
B:HEM471
|
3.0
|
12.2
|
0.5
|
|
C4B
|
B:HEM471
|
3.0
|
12.4
|
0.5
|
|
C4A
|
B:HEM471
|
3.0
|
11.5
|
0.5
|
|
C1D
|
B:HEM471
|
3.1
|
11.5
|
0.5
|
|
C1C
|
B:HEM471
|
3.1
|
12.4
|
0.5
|
|
C1B
|
B:HEM471
|
3.1
|
12.4
|
0.5
|
|
C1A
|
B:HEM471
|
3.1
|
10.9
|
0.5
|
|
C1D
|
B:HEM471
|
3.1
|
11.8
|
0.5
|
|
C4D
|
B:HEM471
|
3.1
|
11.2
|
0.5
|
|
C4C
|
B:HEM471
|
3.1
|
12.5
|
0.5
|
|
C4D
|
B:HEM471
|
3.1
|
10.9
|
0.5
|
|
C1A
|
B:HEM471
|
3.2
|
11.9
|
0.5
|
|
C4A
|
B:HEM471
|
3.2
|
12.5
|
0.5
|
|
CB
|
B:CYS400
|
3.2
|
8.7
|
1.0
|
|
C19
|
B:LEH500
|
3.2
|
21.3
|
1.0
|
|
CHC
|
B:HEM471
|
3.4
|
12.0
|
0.5
|
|
C21
|
B:LEH500
|
3.4
|
21.9
|
1.0
|
|
CHB
|
B:HEM471
|
3.4
|
11.4
|
0.5
|
|
CHD
|
B:HEM471
|
3.4
|
11.6
|
0.5
|
|
CHC
|
B:HEM471
|
3.4
|
12.4
|
0.5
|
|
CHD
|
B:HEM471
|
3.5
|
11.7
|
0.5
|
|
CHA
|
B:HEM471
|
3.5
|
11.6
|
0.5
|
|
CHA
|
B:HEM471
|
3.5
|
11.3
|
0.5
|
|
CHB
|
B:HEM471
|
3.5
|
12.4
|
0.5
|
|
CA
|
B:CYS400
|
3.9
|
7.0
|
1.0
|
|
C2C
|
B:HEM471
|
4.1
|
12.0
|
0.5
|
|
C3C
|
B:HEM471
|
4.2
|
12.3
|
0.5
|
|
C2B
|
B:HEM471
|
4.2
|
11.8
|
0.5
|
|
C3B
|
B:HEM471
|
4.2
|
11.8
|
0.5
|
|
C3B
|
B:HEM471
|
4.2
|
12.8
|
0.5
|
|
C2B
|
B:HEM471
|
4.2
|
10.8
|
0.5
|
|
C3A
|
B:HEM471
|
4.3
|
11.1
|
0.5
|
|
C2A
|
B:HEM471
|
4.3
|
11.0
|
0.5
|
|
C2C
|
B:HEM471
|
4.3
|
10.9
|
0.5
|
|
C2D
|
B:HEM471
|
4.3
|
11.8
|
0.5
|
|
C3C
|
B:HEM471
|
4.3
|
11.9
|
0.5
|
|
C3D
|
B:HEM471
|
4.3
|
11.4
|
0.5
|
|
C2D
|
B:HEM471
|
4.3
|
10.1
|
0.5
|
|
N2
|
B:LEH500
|
4.4
|
22.3
|
1.0
|
|
C3D
|
B:HEM471
|
4.4
|
10.4
|
0.5
|
|
C20
|
B:LEH500
|
4.4
|
22.0
|
1.0
|
|
C2A
|
B:HEM471
|
4.4
|
12.3
|
0.5
|
|
C3A
|
B:HEM471
|
4.4
|
11.5
|
0.5
|
|
N
|
B:GLY402
|
4.7
|
8.6
|
1.0
|
|
C
|
B:CYS400
|
4.7
|
9.7
|
1.0
|
|
N
|
B:ILE401
|
4.8
|
7.9
|
1.0
|
|
CB
|
B:ALA264
|
5.0
|
18.2
|
1.0
|
|
Iron binding site 4 out
of 4 in 3ben
Go back to
Iron Binding Sites List in 3ben
Iron binding site 4 out
of 4 in the Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Structure of N-(12-Imidazolyl-Dodecanoyl)-L-Leucine Inhibitor Bound to the Heme Domain of Cytochrome P450-BM3 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Fe471
b:12.1
occ:0.50
|
FE
|
B:HEM471
|
0.0
|
12.1
|
0.5
|
|
FE
|
B:HEM471
|
0.3
|
12.3
|
0.5
|
|
ND
|
B:HEM471
|
2.0
|
12.3
|
0.5
|
|
NB
|
B:HEM471
|
2.0
|
12.2
|
0.5
|
|
NA
|
B:HEM471
|
2.0
|
13.0
|
0.5
|
|
NC
|
B:HEM471
|
2.0
|
12.2
|
0.5
|
|
NC
|
B:HEM471
|
2.1
|
13.0
|
0.5
|
|
NA
|
B:HEM471
|
2.1
|
12.4
|
0.5
|
|
NB
|
B:HEM471
|
2.1
|
12.2
|
0.5
|
|
N3
|
B:LEH500
|
2.1
|
18.0
|
1.0
|
|
ND
|
B:HEM471
|
2.1
|
12.6
|
0.5
|
|
SG
|
B:CYS400
|
2.4
|
9.1
|
1.0
|
|
C19
|
B:LEH500
|
2.9
|
21.3
|
1.0
|
|
C1D
|
B:HEM471
|
2.9
|
11.8
|
0.5
|
|
C4B
|
B:HEM471
|
3.0
|
12.0
|
0.5
|
|
C1B
|
B:HEM471
|
3.0
|
12.4
|
0.5
|
|
C4C
|
B:HEM471
|
3.0
|
12.5
|
0.5
|
|
C1A
|
B:HEM471
|
3.0
|
11.9
|
0.5
|
|
C4D
|
B:HEM471
|
3.0
|
10.9
|
0.5
|
|
C4A
|
B:HEM471
|
3.0
|
12.5
|
0.5
|
|
C1C
|
B:HEM471
|
3.1
|
12.4
|
0.5
|
|
C1C
|
B:HEM471
|
3.1
|
11.3
|
0.5
|
|
C1A
|
B:HEM471
|
3.1
|
10.9
|
0.5
|
|
C4D
|
B:HEM471
|
3.1
|
11.2
|
0.5
|
|
C1B
|
B:HEM471
|
3.1
|
12.2
|
0.5
|
|
C4A
|
B:HEM471
|
3.1
|
11.5
|
0.5
|
|
C4C
|
B:HEM471
|
3.1
|
12.6
|
0.5
|
|
C4B
|
B:HEM471
|
3.1
|
12.4
|
0.5
|
|
C21
|
B:LEH500
|
3.1
|
21.9
|
1.0
|
|
C1D
|
B:HEM471
|
3.1
|
11.5
|
0.5
|
|
CHD
|
B:HEM471
|
3.4
|
11.7
|
0.5
|
|
CHB
|
B:HEM471
|
3.4
|
12.4
|
0.5
|
|
CHA
|
B:HEM471
|
3.4
|
11.6
|
0.5
|
|
CHC
|
B:HEM471
|
3.4
|
12.0
|
0.5
|
|
CHA
|
B:HEM471
|
3.5
|
11.3
|
0.5
|
|
CHB
|
B:HEM471
|
3.5
|
11.4
|
0.5
|
|
CHC
|
B:HEM471
|
3.5
|
12.4
|
0.5
|
|
CHD
|
B:HEM471
|
3.5
|
11.6
|
0.5
|
|
CB
|
B:CYS400
|
3.5
|
8.7
|
1.0
|
|
N2
|
B:LEH500
|
4.0
|
22.3
|
1.0
|
|
C20
|
B:LEH500
|
4.1
|
22.0
|
1.0
|
|
CA
|
B:CYS400
|
4.1
|
7.0
|
1.0
|
|
C2D
|
B:HEM471
|
4.2
|
10.1
|
0.5
|
|
C2B
|
B:HEM471
|
4.2
|
10.8
|
0.5
|
|
C3B
|
B:HEM471
|
4.2
|
11.8
|
0.5
|
|
C3D
|
B:HEM471
|
4.2
|
10.4
|
0.5
|
|
C3C
|
B:HEM471
|
4.2
|
11.9
|
0.5
|
|
C3A
|
B:HEM471
|
4.3
|
11.5
|
0.5
|
|
C2A
|
B:HEM471
|
4.3
|
12.3
|
0.5
|
|
C2C
|
B:HEM471
|
4.3
|
10.9
|
0.5
|
|
C2A
|
B:HEM471
|
4.3
|
11.0
|
0.5
|
|
C2C
|
B:HEM471
|
4.3
|
12.0
|
0.5
|
|
C3A
|
B:HEM471
|
4.3
|
11.1
|
0.5
|
|
C3C
|
B:HEM471
|
4.3
|
12.3
|
0.5
|
|
C2B
|
B:HEM471
|
4.3
|
11.8
|
0.5
|
|
C3B
|
B:HEM471
|
4.3
|
12.8
|
0.5
|
|
C3D
|
B:HEM471
|
4.3
|
11.4
|
0.5
|
|
C2D
|
B:HEM471
|
4.4
|
11.8
|
0.5
|
|
CB
|
B:ALA264
|
4.8
|
18.2
|
1.0
|
|
N
|
B:GLY402
|
4.8
|
8.6
|
1.0
|
|
C
|
B:CYS400
|
4.9
|
9.7
|
1.0
|
|
N
|
B:ILE401
|
5.0
|
7.9
|
1.0
|
|
Reference:
D.C.Haines,
B.Chen,
D.R.Tomchick,
M.Bondlela,
A.Hegde,
M.Machius,
J.A.Peterson.
Crystal Structure of Inhibitor-Bound P450BM-3 Reveals Open Conformation of Substrate Access Channel. Biochemistry V. 47 3662 2008.
ISSN: ISSN 0006-2960
PubMed: 18298086
DOI: 10.1021/BI7023964
Page generated: Mon Aug 4 23:52:59 2025
|
