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Iron in PDB 3jt8: Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine
Enzymatic activity of Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine
All present enzymatic activity of Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine:
1.14.13.39;
1.14.13.39;
Protein crystallography data
The structure of Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine, PDB code: 3jt8
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 38.11 / 1.95 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 52.191, 111.374, 164.666, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18.7 / 22.2 |
Other elements in 3jt8:
The structure of Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
Iron Binding Sites:
The binding sites of Iron atom in the Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine
(pdb code 3jt8). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine, PDB code: 3jt8:
Jump to Iron binding site number: 1; 2;
In total 2 binding sites of Iron where determined in the Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine, PDB code: 3jt8:
Jump to Iron binding site number: 1; 2;
Iron binding site 1 out of 2 in 3jt8
Go back to
Iron Binding Sites List in 3jt8
Iron binding site 1 out
of 2 in the Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine within 5.0Å range:
|
Iron binding site 2 out of 2 in 3jt8
Go back to
Iron Binding Sites List in 3jt8
Iron binding site 2 out
of 2 in the Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Structure of Neuronal Nitric Oxide Synthase Heme Domain Complexed with N~5~-{3-[(1-Methylethyl)Sulfanyl]Propanimidoyl}-L-Ornithine within 5.0Å range:
|
Reference:
J.D.Martell,
H.Li,
T.Doukov,
P.Martasek,
L.J.Roman,
M.Soltis,
T.L.Poulos,
R.B.Silverman.
Heme-Coordinating Inhibitors of Neuronal Nitric Oxide Synthase. Iron-Thioether Coordination Is Stabilized By Hydrophobic Contacts Without Increased Inhibitor Potency. J.Am.Chem.Soc. V. 132 798 2010.
ISSN: ISSN 0002-7863
PubMed: 20014790
DOI: 10.1021/JA908544F
Page generated: Sun Aug 4 13:35:10 2024
ISSN: ISSN 0002-7863
PubMed: 20014790
DOI: 10.1021/JA908544F
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