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Iron in PDB 3p4p: Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate

Enzymatic activity of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate

All present enzymatic activity of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate:
1.3.99.1;

Protein crystallography data

The structure of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate, PDB code: 3p4p was solved by T.M.Tomasiak, T.L.Archuleta, J.Andr Ll, C.Luna-Ch Vez, T.A.Davis, M.Sarwar, A.J.Ham, W.H.Mcdonald, V.Yankowskaya, H.A.Stern, J.N.Johnston, E.Maklashina, G.Cecchini, T.M.Iverson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.92 / 2.80
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 96.317, 137.633, 270.684, 90.00, 90.00, 90.00
R / Rfree (%) 24.9 / 27.2

Iron Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 18;

Binding sites:

The binding sites of Iron atom in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate (pdb code 3p4p). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 18 binding sites of Iron where determined in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate, PDB code: 3p4p:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iron binding site 1 out of 18 in 3p4p

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Iron binding site 1 out of 18 in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe244

b:98.1
occ:1.00
FE1 B:FES244 0.0 98.1 1.0
SG B:CYS65 1.8 43.8 1.0
S2 B:FES244 2.1 0.8 1.0
S1 B:FES244 2.2 0.3 1.0
SG B:CYS77 2.3 48.6 1.0
FE2 B:FES244 2.8 0.3 1.0
CB B:CYS77 3.1 52.3 1.0
CB B:CYS65 3.3 47.0 1.0
N B:CYS65 3.9 46.1 1.0
SG B:CYS57 4.0 37.1 1.0
N B:ALA60 4.1 44.7 1.0
CA B:ALA60 4.2 43.2 1.0
N B:ARG58 4.2 42.8 1.0
CA B:CYS65 4.3 46.7 1.0
CA B:CYS77 4.3 51.8 1.0
SG B:CYS62 4.4 45.8 1.0
N B:CYS77 4.4 50.7 1.0
CA B:ARG58 4.6 46.3 1.0
N B:SER64 4.7 44.9 1.0
N B:MET59 4.8 56.7 1.0
CB B:LEU75 4.9 49.1 1.0

Iron binding site 2 out of 18 in 3p4p

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Iron binding site 2 out of 18 in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe244

b:0.3
occ:1.00
FE2 B:FES244 0.0 0.3 1.0
SG B:CYS62 1.9 45.8 1.0
S1 B:FES244 2.1 0.3 1.0
S2 B:FES244 2.2 0.8 1.0
SG B:CYS57 2.2 37.1 1.0
FE1 B:FES244 2.8 98.1 1.0
CB B:CYS57 3.2 43.2 1.0
CB B:CYS62 3.3 43.1 1.0
N B:CYS57 3.4 40.8 1.0
N B:CYS62 3.5 40.8 1.0
N B:GLY63 3.7 42.0 1.0
CA B:CYS57 3.8 38.4 1.0
CA B:CYS62 3.8 41.5 1.0
N B:ARG58 3.8 42.8 1.0
N B:SER64 3.9 44.9 1.0
OG B:SER64 4.0 54.9 1.0
N B:ILE61 4.0 42.2 1.0
C B:CYS62 4.0 42.6 1.0
SG B:CYS65 4.2 43.8 1.0
C B:CYS57 4.3 37.8 1.0
N B:SER56 4.3 51.1 1.0
N B:ALA60 4.4 44.7 1.0
C B:SER56 4.5 46.1 1.0
C B:ILE61 4.5 41.8 1.0
CA B:ALA60 4.5 43.2 1.0
SG B:CYS77 4.5 48.6 1.0
CA B:GLY63 4.6 42.3 1.0
C B:ALA60 4.7 43.3 1.0
C B:GLY63 4.7 43.0 1.0
N B:MET59 4.8 56.7 1.0
CA B:SER56 4.8 48.2 1.0
CA B:SER64 4.8 47.5 1.0
CA B:ILE61 4.8 41.5 1.0
N B:CYS65 4.9 46.1 1.0
CA B:ARG58 4.9 46.3 1.0
O B:CYS62 5.0 42.4 1.0
CB B:SER64 5.0 49.9 1.0

Iron binding site 3 out of 18 in 3p4p

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Iron binding site 3 out of 18 in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe245

b:93.3
occ:1.00
FE1 B:F3S245 0.0 93.3 1.0
SG B:CYS204 1.5 46.7 1.0
S3 B:F3S245 2.1 66.0 1.0
S2 B:F3S245 2.2 62.7 1.0
S1 B:F3S245 2.2 70.8 1.0
FE3 B:F3S245 2.5 70.3 1.0
FE4 B:F3S245 2.5 64.3 1.0
CB B:CYS204 3.2 52.2 1.0
S4 B:F3S245 3.8 60.2 1.0
N B:PHE206 3.9 50.5 1.0
CA B:CYS204 3.9 51.7 1.0
CA B:PHE206 4.0 50.0 1.0
CD1 B:ILE224 4.0 41.3 1.0
N B:VAL207 4.1 49.6 1.0
N B:THR205 4.4 50.5 1.0
C B:CYS204 4.5 51.7 1.0
C B:PHE206 4.5 50.2 1.0
SG B:CYS210 4.6 93.0 1.0
SG B:CYS158 4.7 55.1 1.0
N B:GLY208 4.7 52.0 1.0
C B:THR205 4.9 50.8 1.0

Iron binding site 4 out of 18 in 3p4p

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Iron binding site 4 out of 18 in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe245

b:70.3
occ:1.00
FE3 B:F3S245 0.0 70.3 1.0
S3 B:F3S245 2.2 66.0 1.0
S1 B:F3S245 2.2 70.8 1.0
S4 B:F3S245 2.3 60.2 1.0
SG B:CYS210 2.3 93.0 1.0
FE1 B:F3S245 2.5 93.3 1.0
FE4 B:F3S245 2.5 64.3 1.0
CB B:CYS210 3.5 0.3 1.0
S2 B:F3S245 3.7 62.7 1.0
N B:GLY208 3.9 52.0 1.0
SG B:CYS204 3.9 46.7 1.0
N B:CYS210 4.1 80.4 1.0
CA B:GLY208 4.3 52.2 1.0
CA B:CYS210 4.4 86.0 1.0
C B:GLY208 4.5 52.8 1.0
SG B:CYS158 4.5 55.1 1.0
CD1 B:ILE224 4.5 41.3 1.0
N B:TYR209 4.6 55.2 1.0
N B:VAL207 4.8 49.6 1.0
CG B:PRO170 4.8 48.8 1.0
CB B:ALA221 4.9 51.2 1.0
CB B:PRO170 4.9 48.4 1.0
CB B:CYS158 5.0 59.8 1.0
CA B:ALA221 5.0 52.9 1.0

Iron binding site 5 out of 18 in 3p4p

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Iron binding site 5 out of 18 in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe245

b:64.3
occ:1.00
FE4 B:F3S245 0.0 64.3 1.0
S3 B:F3S245 2.1 66.0 1.0
S2 B:F3S245 2.2 62.7 1.0
S4 B:F3S245 2.2 60.2 1.0
SG B:CYS158 2.4 55.1 1.0
FE3 B:F3S245 2.5 70.3 1.0
FE1 B:F3S245 2.5 93.3 1.0
CB B:CYS158 3.5 59.8 1.0
S1 B:F3S245 3.7 70.8 1.0
SG B:CYS204 3.8 46.7 1.0
CA B:CYS158 4.0 58.1 1.0
CB B:GLN160 4.4 59.8 1.0
CB B:VAL207 4.4 51.5 1.0
CG B:GLN160 4.5 63.5 1.0
CD B:PRO159 4.5 60.0 1.0
CE2 B:PHE167 4.6 60.7 1.0
N B:VAL207 4.7 49.6 1.0
SG B:CYS210 4.7 93.0 1.0
C B:CYS158 4.8 59.4 1.0
CG2 B:VAL207 4.8 52.9 1.0
N B:GLN160 4.9 60.6 1.0
N B:GLY208 5.0 52.0 1.0
CB B:CYS204 5.0 52.2 1.0
N B:PRO159 5.0 60.4 1.0

Iron binding site 6 out of 18 in 3p4p

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Iron binding site 6 out of 18 in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe246

b:0.8
occ:1.00
FE1 B:SF4246 0.0 0.8 1.0
SG B:CYS151 1.6 32.5 1.0
S4 B:SF4246 2.1 95.2 1.0
S2 B:SF4246 2.2 94.9 1.0
S3 B:SF4246 2.3 0.9 1.0
FE3 B:SF4246 2.7 0.8 1.0
FE2 B:SF4246 2.7 0.8 1.0
FE4 B:SF4246 2.8 0.8 1.0
CB B:CYS151 3.2 40.5 1.0
N B:CYS151 3.5 39.1 1.0
N B:GLY152 3.7 44.6 1.0
CA B:CYS151 3.8 39.5 1.0
S1 B:SF4246 3.9 86.3 1.0
SG B:CYS154 4.0 44.4 1.0
N B:LEU153 4.1 46.0 1.0
C B:CYS151 4.2 42.0 1.0
SG B:CYS214 4.2 71.1 1.0
CD B:PRO215 4.3 51.3 1.0
SG B:CYS148 4.3 39.5 1.0
C B:ASN150 4.5 40.5 1.0
CG1 B:ILE149 4.6 38.0 1.0
N B:ASN150 4.6 41.8 1.0
CA B:GLY152 4.7 45.5 1.0
CG B:PRO215 4.7 51.2 1.0
CB B:LEU153 4.7 48.3 1.0
CA B:ASN150 4.8 41.6 1.0
C B:GLY152 4.8 47.3 1.0
N B:CYS154 4.8 50.0 1.0
CA B:LEU153 4.9 47.6 1.0

Iron binding site 7 out of 18 in 3p4p

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Iron binding site 7 out of 18 in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe246

b:0.8
occ:1.00
FE2 B:SF4246 0.0 0.8 1.0
SG B:CYS154 1.6 44.4 1.0
S3 B:SF4246 2.0 0.9 1.0
S1 B:SF4246 2.1 86.3 1.0
S4 B:SF4246 2.3 95.2 1.0
FE4 B:SF4246 2.5 0.8 1.0
FE3 B:SF4246 2.6 0.8 1.0
FE1 B:SF4246 2.7 0.8 1.0
CB B:CYS154 3.2 50.8 1.0
S2 B:SF4246 3.6 94.9 1.0
N B:CYS154 3.8 50.0 1.0
SG B:CYS214 4.0 71.1 1.0
SG B:CYS151 4.0 32.5 1.0
CA B:CYS154 4.1 49.4 1.0
SG B:CYS148 4.2 39.5 1.0
CB B:ALA171 4.3 47.8 1.0
CG B:PRO220 4.5 54.5 1.0
N B:LEU153 4.6 46.0 1.0
N B:GLY152 4.7 44.6 1.0
CA B:ALA171 4.9 51.4 1.0
N B:ALA171 4.9 51.0 1.0
C B:LEU153 4.9 49.9 1.0
CA B:GLY152 5.0 45.5 1.0

Iron binding site 8 out of 18 in 3p4p

Go back to Iron Binding Sites List in 3p4p
Iron binding site 8 out of 18 in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe246

b:0.8
occ:1.00
FE3 B:SF4246 0.0 0.8 1.0
SG B:CYS148 1.8 39.5 1.0
S2 B:SF4246 2.1 94.9 1.0
S4 B:SF4246 2.1 95.2 1.0
S1 B:SF4246 2.3 86.3 1.0
FE2 B:SF4246 2.6 0.8 1.0
FE4 B:SF4246 2.7 0.8 1.0
FE1 B:SF4246 2.7 0.8 1.0
CB B:CYS148 3.3 47.2 1.0
S3 B:SF4246 3.6 0.9 1.0
CA B:CYS148 3.8 46.8 1.0
SG B:CYS154 3.9 44.4 1.0
N B:ASN150 4.0 41.8 1.0
SG B:CYS151 4.2 32.5 1.0
SG B:CYS214 4.2 71.1 1.0
N B:ILE149 4.2 45.9 1.0
C B:CYS148 4.3 47.1 1.0
CB B:ALA171 4.4 47.8 1.0
CA B:ASN150 4.4 41.6 1.0
N B:CYS151 4.6 39.1 1.0
CG2 B:VAL218 4.9 48.3 1.0
C B:ASN150 5.0 40.5 1.0
C B:ILE149 5.0 43.9 1.0

Iron binding site 9 out of 18 in 3p4p

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Iron binding site 9 out of 18 in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 9 of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe246

b:0.8
occ:1.00
FE4 B:SF4246 0.0 0.8 1.0
SG B:CYS214 1.7 71.1 1.0
S1 B:SF4246 2.0 86.3 1.0
S2 B:SF4246 2.3 94.9 1.0
S3 B:SF4246 2.3 0.9 1.0
FE2 B:SF4246 2.5 0.8 1.0
FE3 B:SF4246 2.7 0.8 1.0
FE1 B:SF4246 2.8 0.8 1.0
CB B:CYS214 3.1 70.9 1.0
CA B:CYS214 3.7 56.6 1.0
S4 B:SF4246 3.7 95.2 1.0
SG B:CYS154 4.0 44.4 1.0
SG B:CYS151 4.1 32.5 1.0
CD B:PRO215 4.3 51.3 1.0
CG2 B:VAL218 4.3 48.3 1.0
SG B:CYS148 4.3 39.5 1.0
CB B:VAL218 4.3 51.0 1.0
CG B:PRO220 4.6 54.5 1.0
C B:CYS214 4.6 55.9 1.0
N B:PRO215 4.8 53.7 1.0
N B:CYS214 4.8 55.0 1.0

Iron binding site 10 out of 18 in 3p4p

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Iron binding site 10 out of 18 in the Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 10 of Crystal Structure of Menaquinol:Fumarate Oxidoreductase in Complex with Fumarate within 5.0Å range:
probe atom residue distance (Å) B Occ
N:Fe244

b:94.1
occ:1.00
FE1 N:FES244 0.0 94.1 1.0
S1 N:FES244 2.1 90.3 1.0
S2 N:FES244 2.3 76.8 1.0
SG N:CYS77 2.3 0.0 1.0
SG N:CYS65 2.3 98.8 1.0
CB N:CYS65 2.5 0.7 1.0
FE2 N:FES244 2.9 0.9 1.0
CB N:CYS77 3.4 0.5 1.0
CA N:CYS65 3.9 91.2 1.0
N N:CYS65 4.1 90.6 1.0
CA N:ALA60 4.3 87.3 1.0
N N:ALA60 4.3 89.6 1.0
CB N:LEU75 4.4 83.2 1.0
CD2 N:LEU75 4.4 84.1 1.0
SG N:CYS57 4.6 0.1 1.0
N N:CYS77 4.6 97.8 1.0
CA N:CYS77 4.6 0.6 1.0
CD2 N:LEU37 4.6 0.4 1.0
SG N:CYS62 4.7 93.9 1.0
N N:GLY63 4.8 1.0 1.0
CG N:LEU75 4.9 77.0 1.0
N N:ARG58 4.9 0.8 1.0

Reference:

T.M.Tomasiak, T.L.Archuleta, J.Andrell, C.Luna-Chavez, T.A.Davis, M.Sarwar, A.J.Ham, W.H.Mcdonald, V.Yankovskaya, H.A.Stern, J.N.Johnston, E.Maklashina, G.Cecchini, T.M.Iverson. Geometric Restraint Drives on- and Off-Pathway Catalysis By the Escherichia Coli Menaquinol:Fumarate Reductase. J.Biol.Chem. V. 286 3047 2011.
ISSN: ISSN 0021-9258
PubMed: 21098488
DOI: 10.1074/JBC.M110.192849
Page generated: Sun Aug 4 17:24:50 2024

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