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Iron in PDB 3tbg: Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site
Enzymatic activity of Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site
All present enzymatic activity of Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site:
1.14.14.1;
1.14.14.1;
Protein crystallography data
The structure of Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site, PDB code: 3tbg
was solved by
A.Wang,
C.D.Stout,
E.F.Johnson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 36.90 / 2.10 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 57.190, 191.960, 249.480, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 22.2 / 24.7 |
Other elements in 3tbg:
The structure of Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site also contains other interesting chemical elements:
| Zinc | (Zn) | 7 atoms |
Iron Binding Sites:
The binding sites of Iron atom in the Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site
(pdb code 3tbg). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site, PDB code: 3tbg:
Jump to Iron binding site number: 1; 2; 3; 4;
In total 4 binding sites of Iron where determined in the Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site, PDB code: 3tbg:
Jump to Iron binding site number: 1; 2; 3; 4;
Iron binding site 1 out of 4 in 3tbg
Go back to
Iron Binding Sites List in 3tbg
Iron binding site 1 out
of 4 in the Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site within 5.0Å range:
|
Iron binding site 2 out of 4 in 3tbg
Go back to
Iron Binding Sites List in 3tbg
Iron binding site 2 out
of 4 in the Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site within 5.0Å range:
|
Iron binding site 3 out of 4 in 3tbg
Go back to
Iron Binding Sites List in 3tbg
Iron binding site 3 out
of 4 in the Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site within 5.0Å range:
|
Iron binding site 4 out of 4 in 3tbg
Go back to
Iron Binding Sites List in 3tbg
Iron binding site 4 out
of 4 in the Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Human Cytochrome P450 2D6 with Two Thioridazines Bound in Active Site within 5.0Å range:
|
Reference:
A.Wang,
C.D.Stout,
Q.Zhang,
E.F.Johnson.
Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding. J.Biol.Chem. V. 290 5092 2015.
ISSN: ISSN 0021-9258
PubMed: 25555909
DOI: 10.1074/JBC.M114.627661
Page generated: Tue Aug 5 06:59:14 2025
ISSN: ISSN 0021-9258
PubMed: 25555909
DOI: 10.1074/JBC.M114.627661
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