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Iron in PDB 3zgn: Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway
Enzymatic activity of Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway
All present enzymatic activity of Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway:
1.17.1.2;
1.17.1.2;
Protein crystallography data
The structure of Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway, PDB code: 3zgn
was solved by
F.Borel,
E.Barbier,
S.Kratsutsky,
K.Janthawornpong,
M.Rohmer,
C.Dalepoulter,
J.L.Ferrer,
M.Seemann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 46.87 / 1.95 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 112.390, 80.570, 70.620, 90.00, 94.46, 90.00 |
| R / Rfree (%) | 20.5 / 25.8 |
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway
(pdb code 3zgn). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 8 binding sites of Iron where determined in the Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway, PDB code: 3zgn:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Iron where determined in the Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway, PDB code: 3zgn:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Iron binding site 1 out of 8 in 3zgn
Go back to
Iron Binding Sites List in 3zgn
Iron binding site 1 out
of 8 in the Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway within 5.0Å range:
|
Iron binding site 2 out of 8 in 3zgn
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Iron Binding Sites List in 3zgn
Iron binding site 2 out
of 8 in the Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway within 5.0Å range:
|
Iron binding site 3 out of 8 in 3zgn
Go back to
Iron Binding Sites List in 3zgn
Iron binding site 3 out
of 8 in the Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway within 5.0Å range:
|
Iron binding site 4 out of 8 in 3zgn
Go back to
Iron Binding Sites List in 3zgn
Iron binding site 4 out
of 8 in the Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway within 5.0Å range:
|
Iron binding site 5 out of 8 in 3zgn
Go back to
Iron Binding Sites List in 3zgn
Iron binding site 5 out
of 8 in the Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 5 of Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway within 5.0Å range:
|
Iron binding site 6 out of 8 in 3zgn
Go back to
Iron Binding Sites List in 3zgn
Iron binding site 6 out
of 8 in the Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 6 of Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway within 5.0Å range:
|
Iron binding site 7 out of 8 in 3zgn
Go back to
Iron Binding Sites List in 3zgn
Iron binding site 7 out
of 8 in the Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 7 of Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway within 5.0Å range:
|
Iron binding site 8 out of 8 in 3zgn
Go back to
Iron Binding Sites List in 3zgn
Iron binding site 8 out
of 8 in the Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 8 of Crystal Structures of Escherichia Coli Isph in Complex with Tmbpp A Potent Inhibitor of the Methylerythritol Phosphate Pathway within 5.0Å range:
|
Reference:
F.Borel,
E.Barbier,
S.Krasutsky,
K.Janthawornpong,
P.Chaignon,
C.D.Poulter,
J.L.Ferrer,
M.Seemann.
Further Insight Into Crystal Structures of Escherichia Coli Isph/Lytb in Complex with Two Potent Inhibitors of the Mep Pathway: A Starting Point For Rational Design of New Antimicrobials. Chembiochem V. 18 2137 2017.
ISSN: ESSN 1439-7633
PubMed: 28862365
DOI: 10.1002/CBIC.201700363
Page generated: Tue Aug 5 08:43:48 2025
ISSN: ESSN 1439-7633
PubMed: 28862365
DOI: 10.1002/CBIC.201700363
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