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Iron in PDB 4ejh: Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk)
Enzymatic activity of Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk)
All present enzymatic activity of Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk):
1.14.14.1;
1.14.14.1;
Protein crystallography data
The structure of Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk), PDB code: 4ejh
was solved by
N.M.Devore,
E.E.Scott,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 69.77 / 2.35 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 71.678, 119.269, 153.665, 100.59, 101.86, 93.56 |
| R / Rfree (%) | 21.4 / 27.3 |
Iron Binding Sites:
The binding sites of Iron atom in the Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk)
(pdb code 4ejh). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 8 binding sites of Iron where determined in the Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk), PDB code: 4ejh:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Iron where determined in the Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk), PDB code: 4ejh:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Iron binding site 1 out of 8 in 4ejh
Go back to
Iron Binding Sites List in 4ejh
Iron binding site 1 out
of 8 in the Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk) within 5.0Å range:
|
Iron binding site 2 out of 8 in 4ejh
Go back to
Iron Binding Sites List in 4ejh
Iron binding site 2 out
of 8 in the Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk) within 5.0Å range:
|
Iron binding site 3 out of 8 in 4ejh
Go back to
Iron Binding Sites List in 4ejh
Iron binding site 3 out
of 8 in the Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk) within 5.0Å range:
|
Iron binding site 4 out of 8 in 4ejh
Go back to
Iron Binding Sites List in 4ejh
Iron binding site 4 out
of 8 in the Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk) within 5.0Å range:
|
Iron binding site 5 out of 8 in 4ejh
Go back to
Iron Binding Sites List in 4ejh
Iron binding site 5 out
of 8 in the Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 5 of Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk) within 5.0Å range:
|
Iron binding site 6 out of 8 in 4ejh
Go back to
Iron Binding Sites List in 4ejh
Iron binding site 6 out
of 8 in the Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 6 of Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk) within 5.0Å range:
|
Iron binding site 7 out of 8 in 4ejh
Go back to
Iron Binding Sites List in 4ejh
Iron binding site 7 out
of 8 in the Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 7 of Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk) within 5.0Å range:
|
Iron binding site 8 out of 8 in 4ejh
Go back to
Iron Binding Sites List in 4ejh
Iron binding site 8 out
of 8 in the Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 8 of Human Cytochrome P450 2A13 in Complex with 4-(Methylnitrosamino)-1-(3- Pyridyl)-1-Butanone (Nnk) within 5.0Å range:
|
Reference:
N.M.Devore,
E.E.Scott.
Nicotine and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone Binding and Access Channel in Human Cytochrome P450 2A6 and 2A13 Enzymes. J.Biol.Chem. V. 287 26576 2012.
ISSN: ISSN 0021-9258
PubMed: 22700965
DOI: 10.1074/JBC.M112.372813
Page generated: Mon Aug 5 01:39:45 2024
ISSN: ISSN 0021-9258
PubMed: 22700965
DOI: 10.1074/JBC.M112.372813
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