Iron in PDB 4f3a: Structure of RPE65: P6522 Crystal Form, Iridium Derivative

All present enzymatic activity of Structure of RPE65: P6522 Crystal Form, Iridium Derivative:
3.1.1.64;

The structure of Structure of RPE65: P6522 Crystal Form, Iridium Derivative, PDB code: 4f3a was solved by P.D.Kiser, K.Palczewski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.44 / 2.60
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	178.639, 178.639, 86.469, 90.00, 90.00, 120.00
R / Rfree (%)	18.5 / 22.9

The structure of Structure of RPE65: P6522 Crystal Form, Iridium Derivative also contains other interesting chemical elements:

Iridium

(Ir)

1 atom

The binding sites of Iron atom in the Structure of RPE65: P6522 Crystal Form, Iridium Derivative (pdb code 4f3a). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Structure of RPE65: P6522 Crystal Form, Iridium Derivative, PDB code: 4f3a:

Iron binding site 1 out of 1 in the Structure of RPE65: P6522 Crystal Form, Iridium Derivative


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of RPE65: P6522 Crystal Form, Iridium Derivative within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe602 b:27.5 occ:1.00 NE2 A:HIS527 2.1 35.5 1.0 NE2 A:HIS180 2.2 31.0 1.0 NE2 A:HIS241 2.2 32.6 1.0 NE2 A:HIS313 2.3 27.3 1.0 CE1 A:HIS527 3.0 35.8 1.0 CD2 A:HIS313 3.1 27.4 1.0 CD2 A:HIS241 3.1 31.5 1.0 CD2 A:HIS527 3.1 37.5 1.0 CD2 A:HIS180 3.1 33.0 1.0 CE1 A:HIS180 3.2 30.8 1.0 CE1 A:HIS241 3.3 33.9 1.0 CE1 A:HIS313 3.3 28.6 1.0 ND1 A:HIS527 4.1 37.0 1.0 CG A:HIS527 4.2 37.5 1.0 ND1 A:HIS180 4.3 31.5 1.0 CG A:HIS313 4.3 28.9 1.0 CG A:HIS180 4.3 32.0 1.0 CG A:HIS241 4.3 30.7 1.0 ND1 A:HIS241 4.4 32.4 1.0 ND1 A:HIS313 4.4 28.9 1.0 CE1 A:PHE418 4.9 39.2 1.0 CG1 A:VAL134 5.0 39.7 1.0

P.D.Kiser, E.R.Farquhar, W.Shi, X.Sui, M.R.Chance, K.Palczewski. Structure of RPE65 Isomerase in A Lipidic Matrix Reveals Roles For Phospholipids and Iron in Catalysis. Proc.Natl.Acad.Sci.Usa V. 109 E2747 2012.
ISSN: ISSN 0027-8424
PubMed: 23012475
DOI: 10.1073/PNAS.1212025109