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Iron in PDB 4hka: Crystal Structure of Drosophila Melanogaster Tryptophan 2,3- Dioxygenase in Complex with Heme

Enzymatic activity of Crystal Structure of Drosophila Melanogaster Tryptophan 2,3- Dioxygenase in Complex with Heme

All present enzymatic activity of Crystal Structure of Drosophila Melanogaster Tryptophan 2,3- Dioxygenase in Complex with Heme:
1.13.11.11;

Protein crystallography data

The structure of Crystal Structure of Drosophila Melanogaster Tryptophan 2,3- Dioxygenase in Complex with Heme, PDB code: 4hka was solved by W.Huang, J.Ding, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.70
Space group P 64 2 2
Cell size a, b, c (Å), α, β, γ (°) 114.719, 114.719, 213.438, 90.00, 90.00, 120.00
R / Rfree (%) 22.6 / 26.4

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Drosophila Melanogaster Tryptophan 2,3- Dioxygenase in Complex with Heme (pdb code 4hka). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Drosophila Melanogaster Tryptophan 2,3- Dioxygenase in Complex with Heme, PDB code: 4hka:

Iron binding site 1 out of 1 in 4hka

Go back to Iron Binding Sites List in 4hka
Iron binding site 1 out of 1 in the Crystal Structure of Drosophila Melanogaster Tryptophan 2,3- Dioxygenase in Complex with Heme


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Drosophila Melanogaster Tryptophan 2,3- Dioxygenase in Complex with Heme within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe401

b:56.0
occ:1.00
 FE A:HEM401 0.0 56.0 1.0
ND A:HEM401 2.1 55.2 1.0
NB A:HEM401 2.1 56.4 1.0
NA A:HEM401 2.1 57.4 1.0
NC A:HEM401 2.1 56.4 1.0
NE2 A:HIS312 2.2 60.8 1.0
C1B A:HEM401 3.1 57.1 1.0
C1D A:HEM401 3.1 56.1 1.0
C4A A:HEM401 3.1 57.8 1.0
C4B A:HEM401 3.1 57.4 1.0
CE1 A:HIS312 3.1 60.6 1.0
C4D A:HEM401 3.1 56.2 1.0
C1C A:HEM401 3.1 55.5 1.0
C1A A:HEM401 3.1 58.1 1.0
C4C A:HEM401 3.2 56.0 1.0
CD2 A:HIS312 3.3 59.3 1.0
CHB A:HEM401 3.5 57.5 1.0
CHD A:HEM401 3.5 56.4 1.0
CHC A:HEM401 3.5 55.7 1.0
CHA A:HEM401 3.5 56.5 1.0
O A:PHE137 4.3 89.1 1.0
ND1 A:HIS312 4.3 60.5 1.0
C3B A:HEM401 4.4 57.9 1.0
C2D A:HEM401 4.4 55.5 1.0
C2B A:HEM401 4.4 57.4 1.0
C3A A:HEM401 4.4 60.0 1.0
CG A:HIS312 4.4 58.3 1.0
C3D A:HEM401 4.4 55.9 1.0
C2A A:HEM401 4.4 61.2 1.0
C3C A:HEM401 4.4 56.2 1.0
C2C A:HEM401 4.4 57.2 1.0
CB A:PHE137 4.6 85.7 1.0
CD1 A:PHE137 4.7 86.5 1.0
CG2 A:VAL316 4.8 58.7 1.0

Reference:

W.Huang, Z.Gong, J.Li, J.Ding. Crystal Structure of Drosophila Melanogaster Tryptophan 2,3-Dioxygenase Reveals Insights Into Substrate Recognition and Catalytic Mechanism. J.Struct.Biol. V. 181 291 2013.
ISSN: ISSN 1047-8477
PubMed: 23333332
DOI: 10.1016/J.JSB.2013.01.002
Page generated: Mon Aug 5 03:23:03 2024

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