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Iron in PDB 4kbz: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-Hydroxy-Pyridin-2-Yl)-Thiazol-4-Yl]- Acetylamino}-Phenyl-Acetic Acid

Enzymatic activity of Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-Hydroxy-Pyridin-2-Yl)-Thiazol-4-Yl]- Acetylamino}-Phenyl-Acetic Acid

All present enzymatic activity of Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-Hydroxy-Pyridin-2-Yl)-Thiazol-4-Yl]- Acetylamino}-Phenyl-Acetic Acid:
1.14.11.29;

Protein crystallography data

The structure of Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-Hydroxy-Pyridin-2-Yl)-Thiazol-4-Yl]- Acetylamino}-Phenyl-Acetic Acid, PDB code: 4kbz was solved by H.T.Kim, Y.R.Hong, H.J.Chang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 34.18 / 2.15
Space group P 41
Cell size a, b, c (Å), α, β, γ (°) 72.207, 72.207, 46.010, 90.00, 90.00, 90.00
R / Rfree (%) 21.1 / 23

Iron Binding Sites:

The binding sites of Iron atom in the Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-Hydroxy-Pyridin-2-Yl)-Thiazol-4-Yl]- Acetylamino}-Phenyl-Acetic Acid (pdb code 4kbz). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-Hydroxy-Pyridin-2-Yl)-Thiazol-4-Yl]- Acetylamino}-Phenyl-Acetic Acid, PDB code: 4kbz:

Iron binding site 1 out of 1 in 4kbz

Go back to Iron Binding Sites List in 4kbz
Iron binding site 1 out of 1 in the Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-Hydroxy-Pyridin-2-Yl)-Thiazol-4-Yl]- Acetylamino}-Phenyl-Acetic Acid


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-Hydroxy-Pyridin-2-Yl)-Thiazol-4-Yl]- Acetylamino}-Phenyl-Acetic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe502

b:35.7
occ:1.00
 NE2 A:HIS374 2.1 31.2 1.0
N8 A:1QA501 2.1 63.9 1.0
O A:HOH624 2.2 25.8 1.0
OD1 A:ASP315 2.2 30.5 1.0
NE2 A:HIS313 2.2 43.2 1.0
N4 A:1QA501 2.3 61.0 1.0
C7 A:1QA501 2.8 65.0 1.0
C5 A:1QA501 2.9 64.4 1.0
CE1 A:HIS374 2.9 30.7 1.0
CE1 A:HIS313 3.1 43.7 1.0
CD2 A:HIS374 3.2 33.7 1.0
CG A:ASP315 3.2 32.2 1.0
CD2 A:HIS313 3.2 43.9 1.0
C9 A:1QA501 3.4 64.2 1.0
C3 A:1QA501 3.4 61.1 1.0
OD2 A:ASP315 3.4 34.9 1.0
C12 A:1QA501 3.9 64.0 1.0
ND1 A:HIS374 4.1 31.4 1.0
CG A:HIS374 4.2 34.7 1.0
ND1 A:HIS313 4.3 43.3 1.0
CG A:HIS313 4.3 43.3 1.0
C6 A:1QA501 4.3 64.4 1.0
S11 A:1QA501 4.4 65.7 1.0
C10 A:1QA501 4.4 65.1 1.0
CB A:ASP315 4.6 32.8 1.0
C2 A:1QA501 4.7 61.2 1.0
CA A:ASP315 4.9 35.2 1.0
CZ A:PHE366 4.9 31.6 1.0
N A:ASP315 4.9 35.4 1.0

Reference:

H.T.Kim, Y.R.Hong, H.J.Chang. N/A N/A.
Page generated: Tue Aug 5 11:55:27 2025

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