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Iron in PDB 4m11: Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam
Enzymatic activity of Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam
All present enzymatic activity of Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam:
1.14.99.1;
1.14.99.1;
Protein crystallography data
The structure of Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam, PDB code: 4m11
was solved by
S.Xu,
S.Banerjee,
D.J.Hermanson,
L.J.Marnett,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.95 / 2.45 |
| Space group | P 2 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 121.627, 133.538, 180.232, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.2 / 23.1 |
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam
(pdb code 4m11). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam, PDB code: 4m11:
Jump to Iron binding site number: 1; 2; 3; 4;
In total 4 binding sites of Iron where determined in the Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam, PDB code: 4m11:
Jump to Iron binding site number: 1; 2; 3; 4;
Iron binding site 1 out of 4 in 4m11
Go back to
Iron Binding Sites List in 4m11
Iron binding site 1 out
of 4 in the Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam within 5.0Å range:
|
Iron binding site 2 out of 4 in 4m11
Go back to
Iron Binding Sites List in 4m11
Iron binding site 2 out
of 4 in the Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam within 5.0Å range:
|
Iron binding site 3 out of 4 in 4m11
Go back to
Iron Binding Sites List in 4m11
Iron binding site 3 out
of 4 in the Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam within 5.0Å range:
|
Iron binding site 4 out of 4 in 4m11
Go back to
Iron Binding Sites List in 4m11
Iron binding site 4 out
of 4 in the Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Crystal Structure of Murine Cyclooxygenase-2 Complex with Meloxicam within 5.0Å range:
|
Reference:
S.Xu,
D.J.Hermanson,
S.Banerjee,
K.Ghebreselasie,
G.M.Clayton,
R.M.Garavito,
L.J.Marnett.
Oxicams Bind in A Novel Mode to the Cyclooxygenase Active Site Via A Two-Water-Mediated H-Bonding Network. J.Biol.Chem. V. 289 6799 2014.
ISSN: ISSN 0021-9258
PubMed: 24425867
DOI: 10.1074/JBC.M113.517987
Page generated: Tue Aug 5 12:38:54 2025
ISSN: ISSN 0021-9258
PubMed: 24425867
DOI: 10.1074/JBC.M113.517987
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