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Iron in PDB 5e58: Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole
Protein crystallography data
The structure of Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole, PDB code: 5e58
was solved by
M.B.Shah,
C.D.Stout,
J.R.Halpert,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 40.00 / 2.40 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 98.079, 106.066, 106.198, 64.61, 82.53, 69.93 |
| R / Rfree (%) | 21.6 / 28.3 |
Other elements in 5e58:
The structure of Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole also contains other interesting chemical elements:
| Chlorine | (Cl) | 12 atoms |
Iron Binding Sites:
The binding sites of Iron atom in the Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole
(pdb code 5e58). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 6 binding sites of Iron where determined in the Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole, PDB code: 5e58:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Iron where determined in the Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole, PDB code: 5e58:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6;
Iron binding site 1 out of 6 in 5e58
Go back to
Iron Binding Sites List in 5e58
Iron binding site 1 out
of 6 in the Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole within 5.0Å range:
|
Iron binding site 2 out of 6 in 5e58
Go back to
Iron Binding Sites List in 5e58
Iron binding site 2 out
of 6 in the Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole within 5.0Å range:
|
Iron binding site 3 out of 6 in 5e58
Go back to
Iron Binding Sites List in 5e58
Iron binding site 3 out
of 6 in the Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole within 5.0Å range:
|
Iron binding site 4 out of 6 in 5e58
Go back to
Iron Binding Sites List in 5e58
Iron binding site 4 out
of 6 in the Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole within 5.0Å range:
|
Iron binding site 5 out of 6 in 5e58
Go back to
Iron Binding Sites List in 5e58
Iron binding site 5 out
of 6 in the Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 5 of Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole within 5.0Å range:
|
Iron binding site 6 out of 6 in 5e58
Go back to
Iron Binding Sites List in 5e58
Iron binding site 6 out
of 6 in the Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 6 of Crystal Structure of Cytochrome P450 2B35 From Desert Woodrat Neotoma Lepida in Complex with 4-(4-Chlorophenyl)Imidazole within 5.0Å range:
|
Reference:
M.B.Shah,
J.Liu,
L.Huo,
Q.Zhang,
M.D.Dearing,
P.R.Wilderman,
G.D.Szklarz,
C.D.Stout,
J.R.Halpert.
Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives As Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism. Mol.Pharmacol. V. 89 435 2016.
ISSN: ESSN 1521-0111
PubMed: 26826176
DOI: 10.1124/MOL.115.102111
Page generated: Mon Aug 5 23:25:53 2024
ISSN: ESSN 1521-0111
PubMed: 26826176
DOI: 10.1124/MOL.115.102111
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