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Iron in PDB 6csb: V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine
Enzymatic activity of V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine
All present enzymatic activity of V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine:
1.14.14.1;
1.14.14.1;
Protein crystallography data
The structure of V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine, PDB code: 6csb
was solved by
Y.T.Yang,
K.Fujita,
P.F.Wang,
S.C.Im,
N.M.Pearl,
J.Meagher,
J.Stuckey,
L.Waskell,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 48.47 / 2.39 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 57.738, 191.999, 250.460, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.3 / 22.9 |
Other elements in 6csb:
The structure of V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine also contains other interesting chemical elements:
| Zinc | (Zn) | 9 atoms |
Iron Binding Sites:
The binding sites of Iron atom in the V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine
(pdb code 6csb). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine, PDB code: 6csb:
Jump to Iron binding site number: 1; 2; 3; 4;
In total 4 binding sites of Iron where determined in the V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine, PDB code: 6csb:
Jump to Iron binding site number: 1; 2; 3; 4;
Iron binding site 1 out of 4 in 6csb
Go back to
Iron Binding Sites List in 6csb
Iron binding site 1 out
of 4 in the V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine within 5.0Å range:
|
Iron binding site 2 out of 4 in 6csb
Go back to
Iron Binding Sites List in 6csb
Iron binding site 2 out
of 4 in the V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine within 5.0Å range:
|
Iron binding site 3 out of 4 in 6csb
Go back to
Iron Binding Sites List in 6csb
Iron binding site 3 out
of 4 in the V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine within 5.0Å range:
|
Iron binding site 4 out of 4 in 6csb
Go back to
Iron Binding Sites List in 6csb
Iron binding site 4 out
of 4 in the V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of V308E Mutant of Cytochrome P450 2D6 Complexed with Thioridazine within 5.0Å range:
|
Reference:
Y.T.Yang,
F.Fujita,
P.F.Wang,
S.C.Im,
N.M.Pearl,
J.Meagher,
J.Stuckey,
L.Waskell.
Characteristic Conformational Changes on the Distal and Proximal Surfaces of Cytochrome P450 2D6 in Response to Substrate Binding To Be Published.
Page generated: Tue Aug 6 15:12:51 2024
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