Iron in PDB 6ctc: Crystal Structure of Human Transferrin Bound to Triferic Fpc Iron Pyrophosphate

The structure of Crystal Structure of Human Transferrin Bound to Triferic Fpc Iron Pyrophosphate, PDB code: 6ctc was solved by T.E.Edwards, R.Pratt, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.38 / 2.60
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	74.370, 90.160, 110.430, 90.00, 90.00, 90.00
R / Rfree (%)	18 / 25.3

The binding sites of Iron atom in the Crystal Structure of Human Transferrin Bound to Triferic Fpc Iron Pyrophosphate (pdb code 6ctc). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Human Transferrin Bound to Triferic Fpc Iron Pyrophosphate, PDB code: 6ctc:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Crystal Structure of Human Transferrin Bound to Triferic Fpc Iron Pyrophosphate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Human Transferrin Bound to Triferic Fpc Iron Pyrophosphate within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe701 b:0.5 occ:1.00 O4 A:POP704 2.1 0.3 1.0 O6 A:POP704 2.1 0.4 1.0 OH A:TYR188 2.5 0.7 1.0 P2 A:POP704 2.6 0.1 1.0 O3 A:POP704 2.6 0.2 1.0 O A:HOH862 3.2 54.7 1.0 CZ A:TYR188 3.4 0.4 1.0 O A:POP704 3.4 0.9 1.0 CE2 A:TYR188 3.4 0.5 1.0 P1 A:POP704 3.5 0.8 1.0 NH1 A:ARG124 3.6 93.8 1.0 NE A:ARG124 3.6 80.5 1.0 O A:HOH815 3.8 43.2 1.0 O A:HOH813 3.9 58.1 1.0 O5 A:POP704 3.9 0.5 1.0 CZ A:ARG124 4.1 90.2 1.0 O1 A:POP704 4.2 1.0 1.0 NZ A:LYS206 4.4 65.9 1.0 CE1 A:TYR188 4.7 0.3 1.0 CE A:LYS206 4.7 68.3 1.0 O2 A:POP704 4.7 0.7 1.0 CD2 A:TYR188 4.7 98.5 1.0 CD A:ARG124 4.8 74.7 1.0 CG A:ARG124 4.8 66.8 1.0 CB A:ARG124 4.9 60.9 1.0 N A:SER125 4.9 52.6 1.0

Iron binding site 2 out of 2 in the Crystal Structure of Human Transferrin Bound to Triferic Fpc Iron Pyrophosphate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Human Transferrin Bound to Triferic Fpc Iron Pyrophosphate within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe702 b:46.2 occ:1.00 O3 A:CO3703 1.8 45.0 1.0 OH A:TYR517 2.0 61.5 1.0 OD1 A:ASP392 2.1 52.6 1.0 OH A:TYR426 2.1 60.8 1.0 NE2 A:HIS585 2.2 56.7 1.0 C A:CO3703 2.4 42.9 1.0 O2 A:CO3703 2.5 38.6 1.0 CE1 A:HIS585 3.1 41.5 1.0 CZ A:TYR517 3.1 41.9 1.0 CG A:ASP392 3.1 38.8 1.0 CZ A:TYR426 3.2 54.9 1.0 CD2 A:HIS585 3.2 37.8 1.0 CB A:ASP392 3.6 34.9 1.0 O1 A:CO3703 3.7 39.4 1.0 CE1 A:TYR517 3.8 40.4 1.0 CE2 A:TYR426 3.8 40.4 1.0 O A:HOH807 4.0 43.9 1.0 CE2 A:TYR517 4.1 37.0 1.0 OD2 A:ASP392 4.2 48.8 1.0 ND1 A:HIS585 4.2 36.9 1.0 CA A:ASP392 4.2 41.4 1.0 CE1 A:TYR426 4.3 50.7 1.0 CG A:HIS585 4.3 49.9 1.0 NH2 A:ARG456 4.4 37.1 1.0 NH1 A:ARG632 4.4 40.2 1.0 CB A:THR457 4.5 44.2 1.0 OG1 A:THR457 4.7 40.4 1.0 NE A:ARG456 4.7 45.9 1.0 N A:THR457 4.7 37.4 1.0 N A:ALA458 4.8 38.1 1.0 N A:GLY393 4.9 36.8 1.0

R.Pratt, G.J.Handelman, T.E.Edwards, A.Gupta. Ferric Pyrophosphate Citrate: Interactions with Transferrin. Biometals V. 31 1081 2018.
ISSN: ISSN 1572-8773
PubMed: 30311019
DOI: 10.1007/S10534-018-0142-2