Iron in PDB 6fxk: Crystal Structure of Full-Length Human Lysyl Hydroxylase LH3

All present enzymatic activity of Crystal Structure of Full-Length Human Lysyl Hydroxylase LH3:
1.14.11.4;

The structure of Crystal Structure of Full-Length Human Lysyl Hydroxylase LH3, PDB code: 6fxk was solved by L.Scietti, A.Chiapparino, F.De Giorgi, M.Fumagalli, L.Khoriauli, S.Nergadze, S.Basu, V.Olieric, B.Banushi, E.Giulotto, P.Gissen, F.Forneris, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	69.78 / 2.70
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	97.290, 100.140, 226.430, 90.00, 90.00, 90.00
R / Rfree (%)	27.8 / 30.9

The binding sites of Iron atom in the Crystal Structure of Full-Length Human Lysyl Hydroxylase LH3 (pdb code 6fxk). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of Full-Length Human Lysyl Hydroxylase LH3, PDB code: 6fxk:

Iron binding site 1 out of 1 in the Crystal Structure of Full-Length Human Lysyl Hydroxylase LH3


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Full-Length Human Lysyl Hydroxylase LH3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe804 b:94.9 occ:1.00 OD1 A:ASP669 2.1 71.1 1.0 NE2 A:HIS719 2.1 72.1 1.0 O5 A:AKG803 2.1 67.0 1.0 O2 A:AKG803 2.2 79.6 1.0 CE1 A:HIS719 2.3 72.4 1.0 NE2 A:HIS667 2.4 0.6 1.0 C2 A:AKG803 2.6 68.5 1.0 C1 A:AKG803 2.7 83.2 1.0 CG A:ASP669 2.8 70.6 1.0 OD2 A:ASP669 2.9 70.4 1.0 CE1 A:HIS667 3.2 79.8 1.0 CD2 A:HIS667 3.3 74.7 1.0 CD2 A:HIS719 3.5 73.0 1.0 ND1 A:HIS719 3.7 73.4 1.0 O1 A:AKG803 3.9 86.7 1.0 C3 A:AKG803 4.0 53.7 1.0 CG A:HIS719 4.2 73.8 1.0 ND1 A:HIS667 4.2 76.3 1.0 CB A:ASP669 4.3 70.7 1.0 CG A:HIS667 4.3 76.2 1.0 C4 A:AKG803 4.5 51.1 1.0 CZ A:PHE735 4.6 69.5 1.0 CE1 A:PHE735 4.6 68.4 1.0 O A:HIS668 4.9 74.8 1.0 N A:ASP669 5.0 73.2 1.0 C A:HIS668 5.0 74.4 1.0

L.Scietti, A.Chiapparino, F.De Giorgi, M.Fumagalli, L.Khoriauli, S.Nergadze, S.Basu, V.Olieric, L.Cucca, B.Banushi, A.Profumo, E.Giulotto, P.Gissen, F.Forneris. Molecular Architecture of the Multifunctional Collagen Lysyl Hydroxylase and Glycosyltransferase LH3. Nat Commun V. 9 3163 2018.
ISSN: ESSN 2041-1723
PubMed: 30089812
DOI: 10.1038/S41467-018-05631-5