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Iron in PDB 6g0a: The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution.

Enzymatic activity of The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution.

All present enzymatic activity of The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution.:
2.7.7.7;

Protein crystallography data

The structure of The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution., PDB code: 6g0a was solved by V.Parkash, E.Johansson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.98 / 2.62
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 159.895, 67.252, 151.639, 90.00, 111.50, 90.00
R / Rfree (%) 22.4 / 26.5

Other elements in 6g0a:

The structure of The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution. also contains other interesting chemical elements:

Calcium (Ca) 2 atoms

Iron Binding Sites:

The binding sites of Iron atom in the The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution. (pdb code 6g0a). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution., PDB code: 6g0a:

Iron binding site 1 out of 1 in 6g0a

Go back to Iron Binding Sites List in 6g0a
Iron binding site 1 out of 1 in the The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution.


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of The Crystal Structure of the POL2 Catalytic Domain of Dna Polymerase Epsilon Carrying A P301R Substitution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe1304

b:69.4
occ:1.00
SG A:CYS677 2.4 67.6 1.0
SG A:CYS763 2.6 49.7 1.0
CB A:CYS763 3.6 48.0 1.0
O A:CYS677 3.9 54.4 1.0
CB A:CYS677 3.9 55.9 1.0
CA A:CYS763 4.4 47.3 1.0
C A:CYS677 4.5 56.2 1.0
CA A:CYS677 4.9 58.4 1.0

Reference:

V.Parkash, Y.Kulkarni, J.Ter Beek, P.V.Shcherbakova, S.C.L.Kamerlin, E.Johansson. Structural Consequence of the Most Frequently Recurring Cancer-Associated Substitution in Dna Polymerase Epsilon. Nat Commun V. 10 373 2019.
ISSN: ESSN 2041-1723
PubMed: 30670696
DOI: 10.1038/S41467-018-08114-9
Page generated: Tue Aug 6 18:50:07 2024

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