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Iron in PDB 6o9l: Human Holo-Pic in the Closed State

Enzymatic activity of Human Holo-Pic in the Closed State

All present enzymatic activity of Human Holo-Pic in the Closed State:
2.3.1.48; 2.7.11.22; 2.7.11.23; 2.7.7.48; 2.7.7.6; 3.6.4.12;

Other elements in 6o9l:

The structure of Human Holo-Pic in the Closed State also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Zinc (Zn) 17 atoms

Iron Binding Sites:

The binding sites of Iron atom in the Human Holo-Pic in the Closed State (pdb code 6o9l). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Human Holo-Pic in the Closed State, PDB code: 6o9l:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in 6o9l

Go back to Iron Binding Sites List in 6o9l
Iron binding site 1 out of 4 in the Human Holo-Pic in the Closed State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human Holo-Pic in the Closed State within 5.0Å range:
probe atom residue distance (Å) B Occ
0:Fe1000

b:0.0
occ:1.00
FE1 0:SF41000 0.0 0.0 1.0
S4 0:SF41000 2.1 0.0 1.0
S2 0:SF41000 2.1 0.0 1.0
S3 0:SF41000 2.2 0.0 1.0
SG 0:CYS116 2.2 0.0 1.0
FE3 0:SF41000 2.9 0.0 1.0
FE2 0:SF41000 2.9 0.0 1.0
CB 0:CYS116 3.0 0.0 1.0
FE4 0:SF41000 3.3 0.0 1.0
CA 0:CYS116 3.6 0.0 1.0
CD2 0:HIS118 3.7 0.0 1.0
S1 0:SF41000 3.8 0.0 1.0
SG 0:CYS134 4.2 0.0 1.0
NE2 0:HIS118 4.3 0.0 1.0
N 0:ILE117 4.5 0.0 1.0
C 0:CYS116 4.6 0.0 1.0
N 0:CYS116 4.6 0.0 1.0
CG 0:HIS118 4.7 0.0 1.0
O 0:LEU115 4.7 0.0 1.0
CB 0:CYS134 4.8 0.0 1.0
C 0:LEU115 5.0 0.0 1.0
CG1 0:VAL121 5.0 0.0 1.0

Iron binding site 2 out of 4 in 6o9l

Go back to Iron Binding Sites List in 6o9l
Iron binding site 2 out of 4 in the Human Holo-Pic in the Closed State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Human Holo-Pic in the Closed State within 5.0Å range:
probe atom residue distance (Å) B Occ
0:Fe1000

b:0.0
occ:1.00
FE2 0:SF41000 0.0 0.0 1.0
S3 0:SF41000 2.1 0.0 1.0
S4 0:SF41000 2.2 0.0 1.0
S1 0:SF41000 2.2 0.0 1.0
SG 0:CYS155 2.3 0.0 1.0
FE1 0:SF41000 2.9 0.0 1.0
FE4 0:SF41000 3.0 0.0 1.0
FE3 0:SF41000 3.0 0.0 1.0
S2 0:SF41000 3.6 0.0 1.0
CB 0:CYS155 3.8 0.0 1.0
OG1 0:THR138 3.9 0.0 1.0
NE2 0:HIS118 4.2 0.0 1.0
SG 0:CYS134 4.2 0.0 1.0
CD2 0:HIS118 4.3 0.0 1.0
CA 0:CYS155 4.5 0.0 1.0
SG 0:CYS190 4.7 0.0 1.0
SG 0:CYS116 4.9 0.0 1.0

Iron binding site 3 out of 4 in 6o9l

Go back to Iron Binding Sites List in 6o9l
Iron binding site 3 out of 4 in the Human Holo-Pic in the Closed State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Human Holo-Pic in the Closed State within 5.0Å range:
probe atom residue distance (Å) B Occ
0:Fe1000

b:0.0
occ:1.00
FE3 0:SF41000 0.0 0.0 1.0
S1 0:SF41000 2.1 0.0 1.0
S4 0:SF41000 2.2 0.0 1.0
S2 0:SF41000 2.3 0.0 1.0
SG 0:CYS134 2.3 0.0 1.0
FE1 0:SF41000 2.9 0.0 1.0
FE4 0:SF41000 2.9 0.0 1.0
FE2 0:SF41000 3.0 0.0 1.0
S3 0:SF41000 3.6 0.0 1.0
CB 0:CYS134 3.8 0.0 1.0
CD1 0:LEU115 4.2 0.0 1.0
CG 0:LEU115 4.3 0.0 1.0
CD2 0:LEU115 4.7 0.0 1.0
CE2 0:PHE193 4.8 0.0 1.0
OG1 0:THR138 4.8 0.0 1.0
SG 0:CYS116 4.9 0.0 1.0
CA 0:CYS134 4.9 0.0 1.0
SG 0:CYS190 5.0 0.0 1.0
CB 0:CYS116 5.0 0.0 1.0

Iron binding site 4 out of 4 in 6o9l

Go back to Iron Binding Sites List in 6o9l
Iron binding site 4 out of 4 in the Human Holo-Pic in the Closed State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Human Holo-Pic in the Closed State within 5.0Å range:
probe atom residue distance (Å) B Occ
0:Fe1000

b:0.0
occ:1.00
FE4 0:SF41000 0.0 0.0 1.0
S2 0:SF41000 2.1 0.0 1.0
S1 0:SF41000 2.1 0.0 1.0
SG 0:CYS190 2.2 0.0 1.0
S3 0:SF41000 2.2 0.0 1.0
FE3 0:SF41000 2.9 0.0 1.0
FE2 0:SF41000 3.0 0.0 1.0
FE1 0:SF41000 3.3 0.0 1.0
CB 0:CYS190 3.7 0.0 1.0
S4 0:SF41000 3.8 0.0 1.0
CE2 0:PHE157 4.1 0.0 1.0
CA 0:CYS190 4.4 0.0 1.0
O 0:LEU115 4.5 0.0 1.0
CE2 0:PHE193 4.5 0.0 1.0
CD2 0:PHE157 4.6 0.0 1.0
CD2 0:PHE193 4.7 0.0 1.0
SG 0:CYS155 4.8 0.0 1.0
CZ 0:PHE157 4.9 0.0 1.0
CD1 0:LEU115 4.9 0.0 1.0

Reference:

C.Yan, T.Dodd, Y.He, J.A.Tainer, S.E.Tsutakawa, I.Ivanov. Transcription Preinitiation Complex Structure and Dynamics Provide Insight Into Genetic Diseases. Nat.Struct.Mol.Biol. V. 26 397 2019.
ISSN: ESSN 1545-9985
PubMed: 31110295
DOI: 10.1038/S41594-019-0220-3
Page generated: Wed Aug 7 04:12:50 2024

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