Iron in PDB 6o9l: Human Holo-Pic in the Closed State

All present enzymatic activity of Human Holo-Pic in the Closed State:
2.3.1.48; 2.7.11.22; 2.7.11.23; 2.7.7.48; 2.7.7.6; 3.6.4.12;

The structure of Human Holo-Pic in the Closed State also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Zinc	(Zn)	17 atoms

The binding sites of Iron atom in the Human Holo-Pic in the Closed State (pdb code 6o9l). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Human Holo-Pic in the Closed State, PDB code: 6o9l:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Human Holo-Pic in the Closed State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human Holo-Pic in the Closed State within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:0.0 occ:1.00 FE1 0:SF41000 0.0 0.0 1.0 S4 0:SF41000 2.1 0.0 1.0 S2 0:SF41000 2.1 0.0 1.0 S3 0:SF41000 2.2 0.0 1.0 SG 0:CYS116 2.2 0.0 1.0 FE3 0:SF41000 2.9 0.0 1.0 FE2 0:SF41000 2.9 0.0 1.0 CB 0:CYS116 3.0 0.0 1.0 FE4 0:SF41000 3.3 0.0 1.0 CA 0:CYS116 3.6 0.0 1.0 CD2 0:HIS118 3.7 0.0 1.0 S1 0:SF41000 3.8 0.0 1.0 SG 0:CYS134 4.2 0.0 1.0 NE2 0:HIS118 4.3 0.0 1.0 N 0:ILE117 4.5 0.0 1.0 C 0:CYS116 4.6 0.0 1.0 N 0:CYS116 4.6 0.0 1.0 CG 0:HIS118 4.7 0.0 1.0 O 0:LEU115 4.7 0.0 1.0 CB 0:CYS134 4.8 0.0 1.0 C 0:LEU115 5.0 0.0 1.0 CG1 0:VAL121 5.0 0.0 1.0

Iron binding site 2 out of 4 in the Human Holo-Pic in the Closed State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Human Holo-Pic in the Closed State within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:0.0 occ:1.00 FE2 0:SF41000 0.0 0.0 1.0 S3 0:SF41000 2.1 0.0 1.0 S4 0:SF41000 2.2 0.0 1.0 S1 0:SF41000 2.2 0.0 1.0 SG 0:CYS155 2.3 0.0 1.0 FE1 0:SF41000 2.9 0.0 1.0 FE4 0:SF41000 3.0 0.0 1.0 FE3 0:SF41000 3.0 0.0 1.0 S2 0:SF41000 3.6 0.0 1.0 CB 0:CYS155 3.8 0.0 1.0 OG1 0:THR138 3.9 0.0 1.0 NE2 0:HIS118 4.2 0.0 1.0 SG 0:CYS134 4.2 0.0 1.0 CD2 0:HIS118 4.3 0.0 1.0 CA 0:CYS155 4.5 0.0 1.0 SG 0:CYS190 4.7 0.0 1.0 SG 0:CYS116 4.9 0.0 1.0

Iron binding site 3 out of 4 in the Human Holo-Pic in the Closed State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Human Holo-Pic in the Closed State within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:0.0 occ:1.00 FE3 0:SF41000 0.0 0.0 1.0 S1 0:SF41000 2.1 0.0 1.0 S4 0:SF41000 2.2 0.0 1.0 S2 0:SF41000 2.3 0.0 1.0 SG 0:CYS134 2.3 0.0 1.0 FE1 0:SF41000 2.9 0.0 1.0 FE4 0:SF41000 2.9 0.0 1.0 FE2 0:SF41000 3.0 0.0 1.0 S3 0:SF41000 3.6 0.0 1.0 CB 0:CYS134 3.8 0.0 1.0 CD1 0:LEU115 4.2 0.0 1.0 CG 0:LEU115 4.3 0.0 1.0 CD2 0:LEU115 4.7 0.0 1.0 CE2 0:PHE193 4.8 0.0 1.0 OG1 0:THR138 4.8 0.0 1.0 SG 0:CYS116 4.9 0.0 1.0 CA 0:CYS134 4.9 0.0 1.0 SG 0:CYS190 5.0 0.0 1.0 CB 0:CYS116 5.0 0.0 1.0

Iron binding site 4 out of 4 in the Human Holo-Pic in the Closed State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Human Holo-Pic in the Closed State within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:0.0 occ:1.00 FE4 0:SF41000 0.0 0.0 1.0 S2 0:SF41000 2.1 0.0 1.0 S1 0:SF41000 2.1 0.0 1.0 SG 0:CYS190 2.2 0.0 1.0 S3 0:SF41000 2.2 0.0 1.0 FE3 0:SF41000 2.9 0.0 1.0 FE2 0:SF41000 3.0 0.0 1.0 FE1 0:SF41000 3.3 0.0 1.0 CB 0:CYS190 3.7 0.0 1.0 S4 0:SF41000 3.8 0.0 1.0 CE2 0:PHE157 4.1 0.0 1.0 CA 0:CYS190 4.4 0.0 1.0 O 0:LEU115 4.5 0.0 1.0 CE2 0:PHE193 4.5 0.0 1.0 CD2 0:PHE157 4.6 0.0 1.0 CD2 0:PHE193 4.7 0.0 1.0 SG 0:CYS155 4.8 0.0 1.0 CZ 0:PHE157 4.9 0.0 1.0 CD1 0:LEU115 4.9 0.0 1.0

C.Yan, T.Dodd, Y.He, J.A.Tainer, S.E.Tsutakawa, I.Ivanov. Transcription Preinitiation Complex Structure and Dynamics Provide Insight Into Genetic Diseases. Nat.Struct.Mol.Biol. V. 26 397 2019.
ISSN: ESSN 1545-9985
PubMed: 31110295
DOI: 10.1038/S41594-019-0220-3