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Atomistry » Iron » PDB 6pn2-6ppu » 6poa | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Iron » PDB 6pn2-6ppu » 6poa » |
Iron in PDB 6poa: Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 7-(3-(Aminomethyl)-4-(Pyridin-3- Ylmethoxy)Phenyl)-4-Methylquinolin-2-AmineEnzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 7-(3-(Aminomethyl)-4-(Pyridin-3- Ylmethoxy)Phenyl)-4-Methylquinolin-2-Amine
All present enzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 7-(3-(Aminomethyl)-4-(Pyridin-3- Ylmethoxy)Phenyl)-4-Methylquinolin-2-Amine:
1.14.13.39; Protein crystallography data
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 7-(3-(Aminomethyl)-4-(Pyridin-3- Ylmethoxy)Phenyl)-4-Methylquinolin-2-Amine, PDB code: 6poa
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6poa:
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 7-(3-(Aminomethyl)-4-(Pyridin-3- Ylmethoxy)Phenyl)-4-Methylquinolin-2-Amine also contains other interesting chemical elements:
Iron Binding Sites:
The binding sites of Iron atom in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 7-(3-(Aminomethyl)-4-(Pyridin-3- Ylmethoxy)Phenyl)-4-Methylquinolin-2-Amine
(pdb code 6poa). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 7-(3-(Aminomethyl)-4-(Pyridin-3- Ylmethoxy)Phenyl)-4-Methylquinolin-2-Amine, PDB code: 6poa: Jump to Iron binding site number: 1; 2; Iron binding site 1 out of 2 in 6poaGo back to![]() ![]()
Iron binding site 1 out
of 2 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 7-(3-(Aminomethyl)-4-(Pyridin-3- Ylmethoxy)Phenyl)-4-Methylquinolin-2-Amine
![]() Mono view ![]() Stereo pair view
Iron binding site 2 out of 2 in 6poaGo back to![]() ![]()
Iron binding site 2 out
of 2 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 7-(3-(Aminomethyl)-4-(Pyridin-3- Ylmethoxy)Phenyl)-4-Methylquinolin-2-Amine
![]() Mono view ![]() Stereo pair view
Reference:
M.A.Cinelli,
C.T.Reidl,
H.Li,
G.Chreifi,
T.L.Poulos,
R.B.Silverman.
First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target An Isoform-Specific Aspartate. J.Med.Chem. 2020.
Page generated: Wed Aug 6 11:54:07 2025
ISSN: ISSN 0022-2623 PubMed: 32302123 DOI: 10.1021/ACS.JMEDCHEM.9B01573 |
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