Iron in PDB 6tny: Processive Human Polymerase Delta Holoenzyme

All present enzymatic activity of Processive Human Polymerase Delta Holoenzyme:
2.7.7.7;

The structure of Processive Human Polymerase Delta Holoenzyme also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Iron atom in the Processive Human Polymerase Delta Holoenzyme (pdb code 6tny). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Processive Human Polymerase Delta Holoenzyme, PDB code: 6tny:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Processive Human Polymerase Delta Holoenzyme


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Processive Human Polymerase Delta Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1202 b:40.6 occ:1.00 FE1 A:SF41202 0.0 40.6 1.0 SG A:CYS1071 2.3 40.6 1.0 S3 A:SF41202 2.3 40.6 1.0 S2 A:SF41202 2.3 40.6 1.0 S4 A:SF41202 2.3 40.6 1.0 FE4 A:SF41202 2.7 40.6 1.0 FE3 A:SF41202 2.7 40.6 1.0 FE2 A:SF41202 2.7 40.6 1.0 CB A:CYS1071 3.3 40.6 1.0 O A:CYS1071 3.9 40.6 1.0 S1 A:SF41202 3.9 40.6 1.0 CG2 A:ILE1078 4.0 40.6 1.0 C A:CYS1071 4.4 40.6 1.0 SG A:CYS1076 4.4 30.9 1.0 CA A:CYS1071 4.4 40.6 1.0 CB A:SER1073 4.5 35.8 1.0 CB A:CYS1076 4.6 30.9 1.0 SG A:CYS1058 4.6 40.6 1.0 SG A:CYS1061 4.8 24.8 1.0 NH1 A:ARG1082 4.9 40.6 1.0 CB A:ILE1078 4.9 40.6 1.0 N A:SER1073 4.9 35.8 1.0

Iron binding site 2 out of 4 in the Processive Human Polymerase Delta Holoenzyme


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Processive Human Polymerase Delta Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1202 b:40.6 occ:1.00 FE2 A:SF41202 0.0 40.6 1.0 CG2 A:ILE1078 2.3 40.6 1.0 SG A:CYS1076 2.3 30.9 1.0 S4 A:SF41202 2.3 40.6 1.0 S1 A:SF41202 2.3 40.6 1.0 S3 A:SF41202 2.3 40.6 1.0 CB A:ILE1078 2.4 40.6 1.0 FE3 A:SF41202 2.7 40.6 1.0 FE1 A:SF41202 2.7 40.6 1.0 FE4 A:SF41202 2.8 40.6 1.0 CG1 A:ILE1078 3.3 40.6 1.0 CB A:CYS1076 3.3 30.9 1.0 CA A:ILE1078 3.6 40.6 1.0 N A:PHE1079 3.9 40.6 1.0 S2 A:SF41202 3.9 40.6 1.0 N A:ILE1078 4.0 40.6 1.0 C A:ILE1078 4.0 40.6 1.0 CD1 A:ILE1078 4.6 40.6 1.0 CA A:CYS1076 4.7 30.9 1.0 SG A:CYS1058 4.8 40.6 1.0 SG A:CYS1071 4.9 40.6 1.0 C A:CYS1076 4.9 30.9 1.0 CA A:PHE1079 5.0 40.6 1.0

Iron binding site 3 out of 4 in the Processive Human Polymerase Delta Holoenzyme


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Processive Human Polymerase Delta Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1202 b:40.6 occ:1.00 FE3 A:SF41202 0.0 40.6 1.0 S1 A:SF41202 2.3 40.6 1.0 SG A:CYS1058 2.3 40.6 1.0 S4 A:SF41202 2.3 40.6 1.0 S2 A:SF41202 2.3 40.6 1.0 CG2 A:ILE1078 2.3 40.6 1.0 FE2 A:SF41202 2.7 40.6 1.0 FE4 A:SF41202 2.7 40.6 1.0 FE1 A:SF41202 2.7 40.6 1.0 CB A:CYS1058 3.5 40.6 1.0 CA A:CYS1058 3.7 40.6 1.0 CB A:ILE1078 3.7 40.6 1.0 S3 A:SF41202 3.8 40.6 1.0 N A:CYS1058 4.4 40.6 1.0 CG1 A:ILE1078 4.5 40.6 1.0 NE A:ARG1082 4.5 40.6 1.0 SG A:CYS1061 4.8 24.8 1.0 SG A:CYS1071 4.8 40.6 1.0 C A:CYS1058 4.9 40.6 1.0 SG A:CYS1076 4.9 30.9 1.0 NH1 A:ARG1082 5.0 40.6 1.0 CB A:CYS1061 5.0 24.8 1.0 CA A:ILE1078 5.0 40.6 1.0

Iron binding site 4 out of 4 in the Processive Human Polymerase Delta Holoenzyme


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Processive Human Polymerase Delta Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1202 b:40.6 occ:1.00 FE4 A:SF41202 0.0 40.6 1.0 S2 A:SF41202 2.3 40.6 1.0 S3 A:SF41202 2.3 40.6 1.0 S1 A:SF41202 2.3 40.6 1.0 SG A:CYS1061 2.4 24.8 1.0 FE1 A:SF41202 2.7 40.6 1.0 FE3 A:SF41202 2.7 40.6 1.0 FE2 A:SF41202 2.8 40.6 1.0 CB A:CYS1061 3.4 24.8 1.0 S4 A:SF41202 3.9 40.6 1.0 SG A:CYS1076 4.1 30.9 1.0 CG2 A:ILE1078 4.1 40.6 1.0 SG A:CYS1071 4.4 40.6 1.0 CB A:ILE1078 4.7 40.6 1.0 CA A:CYS1061 4.8 24.8 1.0 SG A:CYS1058 4.8 40.6 1.0 CA A:CYS1058 5.0 40.6 1.0

C.Lancey, M.Tehseen, V.S.Raducanu, F.Rashid, N.Merino, T.J.Ragan, C.Savva, M.S.Zaher, A.Shirbini, F.J.Blanco, S.M.Hamdan, A.De Biasio. Structure of the Processive Human Pol Delta Holoenzyme To Be Published.