Iron in PDB 7ad8: Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit

All present enzymatic activity of Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit:
3.6.4.12;

The structure of Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit also contains other interesting chemical elements:

Zinc

(Zn)

6 atoms

The binding sites of Iron atom in the Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit (pdb code 7ad8). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit, PDB code: 7ad8:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe1000 b:97.5 occ:1.00 FE1 B:SF41000 0.0 97.5 1.0 S4 B:SF41000 2.3 97.5 1.0 S2 B:SF41000 2.3 97.5 1.0 S3 B:SF41000 2.3 97.5 1.0 FE3 B:SF41000 2.7 97.5 1.0 FE2 B:SF41000 2.7 97.5 1.0 FE4 B:SF41000 2.7 97.5 1.0 SG B:CYS116 3.1 100.8 1.0 S1 B:SF41000 3.9 97.5 1.0 CA B:CYS116 4.0 100.8 1.0 N B:ILE117 4.1 110.0 1.0 CB B:CYS116 4.2 100.8 1.0 CG1 B:VAL121 4.3 130.3 1.0 N B:HIS118 4.4 121.0 1.0 CB B:HIS118 4.5 121.0 1.0 O B:LEU115 4.6 94.5 1.0 C B:CYS116 4.6 100.8 1.0

Iron binding site 2 out of 4 in the Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe1000 b:97.5 occ:1.00 FE2 B:SF41000 0.0 97.5 1.0 S3 B:SF41000 2.3 97.5 1.0 S1 B:SF41000 2.3 97.5 1.0 S4 B:SF41000 2.3 97.5 1.0 FE4 B:SF41000 2.7 97.5 1.0 FE3 B:SF41000 2.7 97.5 1.0 FE1 B:SF41000 2.7 97.5 1.0 SG B:CYS155 3.1 116.3 1.0 CB B:CYS155 3.8 116.3 1.0 S2 B:SF41000 3.9 97.5 1.0 CB B:HIS118 4.5 121.0 1.0 SG B:CYS134 4.5 121.7 1.0 CG1 B:VAL121 5.0 130.3 1.0

Iron binding site 3 out of 4 in the Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe1000 b:97.5 occ:1.00 FE3 B:SF41000 0.0 97.5 1.0 S2 B:SF41000 2.3 97.5 1.0 S4 B:SF41000 2.3 97.5 1.0 S1 B:SF41000 2.3 97.5 1.0 FE4 B:SF41000 2.7 97.5 1.0 FE1 B:SF41000 2.7 97.5 1.0 FE2 B:SF41000 2.7 97.5 1.0 SG B:CYS134 3.1 121.7 1.0 S3 B:SF41000 3.9 97.5 1.0 CB B:CYS134 4.2 121.7 1.0 SG B:CYS190 4.8 105.4 1.0 NE B:ARG112 4.9 99.1 1.0 CE2 B:PHE193 4.9 96.4 1.0

Iron binding site 4 out of 4 in the Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Core Tfiih-Xpa-Dna Complex with Modelled P62 Subunit within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe1000 b:97.5 occ:1.00 FE4 B:SF41000 0.0 97.5 1.0 S1 B:SF41000 2.3 97.5 1.0 S3 B:SF41000 2.3 97.5 1.0 S2 B:SF41000 2.3 97.5 1.0 FE3 B:SF41000 2.7 97.5 1.0 FE2 B:SF41000 2.7 97.5 1.0 FE1 B:SF41000 2.7 97.5 1.0 SG B:CYS190 3.1 105.4 1.0 CB B:CYS190 3.7 105.4 1.0 S4 B:SF41000 3.9 97.5 1.0 SG B:CYS155 4.2 116.3 1.0 CA B:CYS190 4.3 105.4 1.0 CB B:PHE157 4.4 117.4 1.0 CD B:PRO191 4.5 96.7 1.0 N B:TYR158 4.9 118.8 1.0

J.T.Barnett, J.Kuper, W.Koelmel, C.Kisker, N.M.Kad. The Tfiih Subunits P44/P62 Act As A Damage Sensor During Nucleotide Excision Repair. Nucleic Acids Res. V. 48 12689 2020.
ISSN: ESSN 1362-4962
PubMed: 33166411
DOI: 10.1093/NAR/GKAA973