Iron in PDB 7fji: Human Pol III Elongation Complex

All present enzymatic activity of Human Pol III Elongation Complex:
2.7.7.6;

The structure of Human Pol III Elongation Complex also contains other interesting chemical elements:

Zinc

(Zn)

7 atoms

The binding sites of Iron atom in the Human Pol III Elongation Complex (pdb code 7fji). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Human Pol III Elongation Complex, PDB code: 7fji:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Human Pol III Elongation Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human Pol III Elongation Complex within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:119.5 occ:1.00 FE1 P:SF4401 0.0 119.5 1.0 S3 P:SF4401 2.1 119.5 1.0 S2 P:SF4401 2.1 119.5 1.0 S4 P:SF4401 2.1 119.5 1.0 SG P:CYS287 2.6 121.3 1.0 FE4 P:SF4401 3.0 119.5 1.0 FE2 P:SF4401 3.0 119.5 1.0 FE3 P:SF4401 3.0 119.5 1.0 CB P:CYS287 3.1 121.3 1.0 S1 P:SF4401 3.7 119.5 1.0 CB O:ASN445 3.8 118.3 1.0 CA P:CYS287 4.0 121.3 1.0 OD1 O:ASN445 4.2 118.3 1.0 CG O:ASN445 4.2 118.3 1.0 SG P:CYS290 4.7 126.7 1.0 CG P:MET310 4.8 121.4 1.0 O P:CYS287 4.9 121.3 1.0 CB P:PRO304 5.0 112.1 1.0 SD P:MET310 5.0 121.4 1.0 N P:CYS287 5.0 121.3 1.0

Iron binding site 2 out of 4 in the Human Pol III Elongation Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Human Pol III Elongation Complex within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:119.5 occ:1.00 FE2 P:SF4401 0.0 119.5 1.0 S3 P:SF4401 2.1 119.5 1.0 S4 P:SF4401 2.1 119.5 1.0 S1 P:SF4401 2.1 119.5 1.0 CD2 P:PHE293 2.6 122.0 1.0 CB P:CYS307 3.0 120.8 1.0 FE3 P:SF4401 3.0 119.5 1.0 FE1 P:SF4401 3.0 119.5 1.0 FE4 P:SF4401 3.0 119.5 1.0 SG P:CYS307 3.2 120.8 1.0 CE2 P:PHE293 3.3 122.0 1.0 CG P:PHE293 3.7 122.0 1.0 S2 P:SF4401 3.7 119.5 1.0 CB P:PHE293 4.0 122.0 1.0 CD2 P:TYR309 4.4 119.9 1.0 CA P:CYS307 4.5 120.8 1.0 CB P:TYR309 4.6 119.9 1.0 CZ P:PHE293 4.7 122.0 1.0 O P:PHE293 4.7 122.0 1.0 CA P:PRO304 4.8 112.1 1.0 SG P:CYS290 4.9 126.7 1.0 CB P:PRO304 4.9 112.1 1.0 CD1 P:PHE293 4.9 122.0 1.0

Iron binding site 3 out of 4 in the Human Pol III Elongation Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Human Pol III Elongation Complex within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:119.5 occ:1.00 FE3 P:SF4401 0.0 119.5 1.0 S1 P:SF4401 2.1 119.5 1.0 S2 P:SF4401 2.1 119.5 1.0 S4 P:SF4401 2.1 119.5 1.0 O P:PHE293 2.4 122.0 1.0 FE2 P:SF4401 3.0 119.5 1.0 FE1 P:SF4401 3.0 119.5 1.0 FE4 P:SF4401 3.0 119.5 1.0 C P:PHE293 3.0 122.0 1.0 CB P:PHE293 3.3 122.0 1.0 CA P:PHE293 3.7 122.0 1.0 S3 P:SF4401 3.7 119.5 1.0 N P:ASP294 3.9 118.9 1.0 SG P:CYS287 3.9 121.3 1.0 SG P:CYS290 3.9 126.7 1.0 CD2 P:PHE293 4.0 122.0 1.0 CG P:PHE293 4.1 122.0 1.0 CA P:ASP294 4.2 118.9 1.0 OD1 O:ASN445 4.3 118.3 1.0 SG P:CYS296 4.5 104.7 1.0 C P:ASP294 4.8 118.9 1.0 O P:ASP294 4.9 118.9 1.0 CG O:ASN445 4.9 118.3 1.0 N P:PHE293 5.0 122.0 1.0

Iron binding site 4 out of 4 in the Human Pol III Elongation Complex


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Human Pol III Elongation Complex within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:119.5 occ:1.00 FE4 P:SF4401 0.0 119.5 1.0 S2 P:SF4401 2.1 119.5 1.0 S3 P:SF4401 2.1 119.5 1.0 S1 P:SF4401 2.1 119.5 1.0 CB P:PRO304 2.5 112.1 1.0 FE1 P:SF4401 3.0 119.5 1.0 FE2 P:SF4401 3.0 119.5 1.0 FE3 P:SF4401 3.0 119.5 1.0 CA P:PRO304 3.2 112.1 1.0 CG O:ASN445 3.2 118.3 1.0 ND2 O:ASN445 3.4 118.3 1.0 CG P:PRO304 3.4 112.1 1.0 OD1 O:ASN445 3.5 118.3 1.0 CB O:ASN445 3.7 118.3 1.0 S4 P:SF4401 3.7 119.5 1.0 N P:PRO304 3.8 112.1 1.0 CD P:PRO304 3.8 112.1 1.0 SG P:CYS296 4.2 104.7 1.0 O P:ILE302 4.5 111.4 1.0 C P:PRO304 4.5 112.1 1.0 O P:PHE293 4.5 122.0 1.0 C P:SER303 4.7 113.1 1.0 CB P:CYS307 4.7 120.8 1.0 CB P:CYS296 4.7 104.7 1.0 O P:PRO304 4.8 112.1 1.0 CA O:ASN445 4.9 118.3 1.0

H.Hou, Y.Xu. Human Pol III Elongation Complex To Be Published.