Iron in PDB 7l0e: Crystal Structure of Bovine RPE65 in Complex with Gem-Difluoro Emixustat and Palmitate

All present enzymatic activity of Crystal Structure of Bovine RPE65 in Complex with Gem-Difluoro Emixustat and Palmitate:
3.1.1.64; 5.3.3.22;

The structure of Crystal Structure of Bovine RPE65 in Complex with Gem-Difluoro Emixustat and Palmitate, PDB code: 7l0e was solved by P.D.Kiser, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.87 / 1.90
Space group	P 65
Cell size a, b, c (Å), α, β, γ (°)	175.425, 175.425, 86.668, 90, 90, 120
R / Rfree (%)	17.7 / 20.1

The structure of Crystal Structure of Bovine RPE65 in Complex with Gem-Difluoro Emixustat and Palmitate also contains other interesting chemical elements:

Fluorine

(F)

4 atoms

The binding sites of Iron atom in the Crystal Structure of Bovine RPE65 in Complex with Gem-Difluoro Emixustat and Palmitate (pdb code 7l0e). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Bovine RPE65 in Complex with Gem-Difluoro Emixustat and Palmitate, PDB code: 7l0e:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Crystal Structure of Bovine RPE65 in Complex with Gem-Difluoro Emixustat and Palmitate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Bovine RPE65 in Complex with Gem-Difluoro Emixustat and Palmitate within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe601 b:37.2 occ:1.00 O2 A:PLM602 2.0 60.2 1.0 NE2 A:HIS527 2.2 36.5 1.0 NE2 A:HIS180 2.2 37.7 1.0 NE2 A:HIS241 2.2 36.3 1.0 NE2 A:HIS313 2.2 35.8 1.0 CD2 A:HIS527 3.1 37.0 1.0 CD2 A:HIS313 3.1 36.0 1.0 C1 A:PLM602 3.1 67.0 1.0 CE1 A:HIS527 3.1 38.2 1.0 CE1 A:HIS180 3.1 38.1 1.0 CD2 A:HIS241 3.1 36.1 1.0 CD2 A:HIS180 3.2 36.8 1.0 CE1 A:HIS241 3.2 37.1 1.0 CE1 A:HIS313 3.3 35.4 1.0 C3 A:PLM602 3.4 69.5 1.0 C2 A:PLM602 3.6 66.3 1.0 CG A:HIS527 4.2 38.3 1.0 ND1 A:HIS527 4.2 37.5 1.0 O1 A:PLM602 4.2 67.8 1.0 ND1 A:HIS180 4.2 38.9 1.0 CG A:HIS313 4.3 35.6 1.0 ND1 A:HIS241 4.3 36.0 1.0 CG A:HIS241 4.3 34.7 1.0 CG A:HIS180 4.3 37.5 1.0 C4 A:PLM602 4.3 68.6 1.0 ND1 A:HIS313 4.3 35.1 1.0 CG1 A:VAL134 4.8 41.8 1.0

Iron binding site 2 out of 2 in the Crystal Structure of Bovine RPE65 in Complex with Gem-Difluoro Emixustat and Palmitate


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Bovine RPE65 in Complex with Gem-Difluoro Emixustat and Palmitate within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe601 b:35.8 occ:1.00 O2 B:PLM602 2.0 57.4 1.0 NE2 B:HIS527 2.2 35.0 1.0 NE2 B:HIS241 2.2 36.3 1.0 NE2 B:HIS180 2.2 37.3 1.0 NE2 B:HIS313 2.2 34.5 1.0 CD2 B:HIS527 3.1 34.9 1.0 CD2 B:HIS313 3.1 34.5 1.0 CE1 B:HIS527 3.1 37.0 1.0 CD2 B:HIS241 3.1 35.0 1.0 CE1 B:HIS180 3.1 38.4 1.0 C1 B:PLM602 3.2 63.4 1.0 CE1 B:HIS241 3.2 36.6 1.0 CD2 B:HIS180 3.2 36.1 1.0 CE1 B:HIS313 3.2 34.2 1.0 C3 B:PLM602 3.4 63.1 1.0 C2 B:PLM602 3.8 62.5 1.0 ND1 B:HIS527 4.2 36.3 1.0 CG B:HIS527 4.2 36.5 1.0 O1 B:PLM602 4.2 65.5 1.0 CG B:HIS313 4.2 33.6 1.0 ND1 B:HIS180 4.3 38.5 1.0 ND1 B:HIS241 4.3 36.3 1.0 C4 B:PLM602 4.3 61.2 1.0 CG B:HIS241 4.3 35.2 1.0 ND1 B:HIS313 4.3 33.6 1.0 CG B:HIS180 4.3 37.3 1.0 CG1 B:VAL134 4.8 39.1 1.0

P.D.Kiser, P.D.Kiser. N/A N/A.