Iron in PDB 7ml3: General Transcription Factor Tfiih (Weak Binding)

All present enzymatic activity of General Transcription Factor Tfiih (Weak Binding):
3.6.4.12;

The structure of General Transcription Factor Tfiih (Weak Binding) also contains other interesting chemical elements:

Zinc

(Zn)

7 atoms

The binding sites of Iron atom in the General Transcription Factor Tfiih (Weak Binding) (pdb code 7ml3). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the General Transcription Factor Tfiih (Weak Binding), PDB code: 7ml3:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the General Transcription Factor Tfiih (Weak Binding)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of General Transcription Factor Tfiih (Weak Binding) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe801 b:0.0 occ:1.00 FE1 0:SF4801 0.0 0.0 1.0 S4 0:SF4801 2.3 0.0 1.0 S2 0:SF4801 2.3 0.0 1.0 S3 0:SF4801 2.3 0.0 1.0 FE3 0:SF4801 2.7 0.0 1.0 FE2 0:SF4801 2.7 0.0 1.0 FE4 0:SF4801 2.8 0.0 1.0 CA 0:CYS115 3.0 117.6 1.0 SG 0:CYS115 3.3 117.6 1.0 CB 0:CYS115 3.5 117.6 1.0 N 0:LEU116 3.5 100.9 1.0 C 0:CYS115 3.7 117.6 1.0 S1 0:SF4801 3.9 0.0 1.0 O 0:LEU114 4.0 146.6 1.0 N 0:CYS115 4.1 117.6 1.0 CB 0:CYS191 4.4 115.3 1.0 SG 0:CYS133 4.4 46.6 1.0 C 0:LEU114 4.4 146.6 1.0 SG 0:CYS156 4.5 90.8 1.0 N 0:HIS117 4.5 89.3 1.0 CB 0:TYR193 4.6 84.4 1.0 O 0:CYS115 4.8 117.6 1.0 CA 0:LEU116 4.8 100.9 1.0 CA 0:CYS191 4.8 115.3 1.0 CB 0:ARG111 4.9 123.3 1.0 CB 0:CYS133 5.0 46.6 1.0

Iron binding site 2 out of 4 in the General Transcription Factor Tfiih (Weak Binding)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of General Transcription Factor Tfiih (Weak Binding) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe801 b:0.0 occ:1.00 FE2 0:SF4801 0.0 0.0 1.0 SG 0:CYS156 2.1 90.8 1.0 S3 0:SF4801 2.3 0.0 1.0 S4 0:SF4801 2.3 0.0 1.0 S1 0:SF4801 2.3 0.0 1.0 FE3 0:SF4801 2.7 0.0 1.0 FE1 0:SF4801 2.7 0.0 1.0 FE4 0:SF4801 2.7 0.0 1.0 SG 0:CYS115 2.9 117.6 1.0 CB 0:HIS117 3.1 89.3 1.0 CE 0:MET136 3.4 134.6 1.0 CB 0:CYS156 3.4 90.8 1.0 N 0:HIS117 3.8 89.3 1.0 S2 0:SF4801 3.9 0.0 1.0 CA 0:HIS117 4.0 89.3 1.0 CG 0:HIS117 4.1 89.3 1.0 SG 0:CYS133 4.3 46.6 1.0 CB 0:CYS115 4.3 117.6 1.0 CB 0:CYS133 4.5 46.6 1.0 SD 0:MET136 4.5 134.6 1.0 CA 0:CYS115 4.6 117.6 1.0 CD2 0:TYR158 4.6 101.9 1.0 N 0:LEU116 4.6 100.9 1.0 CG2 0:VAL120 4.6 54.5 1.0 CA 0:CYS156 4.7 90.8 1.0 C 0:CYS115 4.7 117.6 1.0 CD2 0:HIS117 4.7 89.3 1.0 CB 0:VAL120 4.9 54.5 1.0 C 0:LEU116 4.9 100.9 1.0

Iron binding site 3 out of 4 in the General Transcription Factor Tfiih (Weak Binding)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of General Transcription Factor Tfiih (Weak Binding) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe801 b:0.0 occ:1.00 FE3 0:SF4801 0.0 0.0 1.0 SG 0:CYS133 1.9 46.6 1.0 S4 0:SF4801 2.2 0.0 1.0 S1 0:SF4801 2.3 0.0 1.0 S2 0:SF4801 2.3 0.0 1.0 FE1 0:SF4801 2.7 0.0 1.0 FE2 0:SF4801 2.7 0.0 1.0 FE4 0:SF4801 2.7 0.0 1.0 CB 0:CYS133 2.8 46.6 1.0 S3 0:SF4801 3.8 0.0 1.0 CA 0:CYS133 3.8 46.6 1.0 SG 0:CYS156 3.8 90.8 1.0 CE2 0:PHE194 4.2 83.2 1.0 SG 0:CYS115 4.2 117.6 1.0 CE 0:MET136 4.3 134.6 1.0 CZ 0:PHE194 4.4 83.2 1.0 O 0:CYS133 4.4 46.6 1.0 OG1 0:THR137 4.4 144.2 1.0 C 0:CYS133 4.5 46.6 1.0 NE 0:ARG111 4.5 123.3 1.0 CD 0:ARG111 4.6 123.3 1.0 CG 0:ARG111 4.7 123.3 1.0 CD2 0:PHE194 4.9 83.2 1.0 CB 0:CYS115 4.9 117.6 1.0 N 0:CYS133 5.0 46.6 1.0

Iron binding site 4 out of 4 in the General Transcription Factor Tfiih (Weak Binding)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of General Transcription Factor Tfiih (Weak Binding) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe801 b:0.0 occ:1.00 FE4 0:SF4801 0.0 0.0 1.0 S1 0:SF4801 2.2 0.0 1.0 S2 0:SF4801 2.3 0.0 1.0 S3 0:SF4801 2.3 0.0 1.0 FE3 0:SF4801 2.7 0.0 1.0 FE2 0:SF4801 2.7 0.0 1.0 FE1 0:SF4801 2.8 0.0 1.0 CB 0:CYS191 3.0 115.3 1.0 SG 0:CYS156 3.1 90.8 1.0 CB 0:CYS156 3.6 90.8 1.0 CB 0:TYR158 3.8 101.9 1.0 S4 0:SF4801 3.9 0.0 1.0 CA 0:CYS191 4.1 115.3 1.0 SG 0:CYS191 4.1 115.3 1.0 CE2 0:PHE194 4.2 83.2 1.0 N 0:HIS159 4.2 57.3 1.0 SG 0:CYS133 4.2 46.6 1.0 CD2 0:PHE194 4.3 83.2 1.0 CD2 0:TYR158 4.6 101.9 1.0 CG 0:TYR158 4.6 101.9 1.0 C 0:TYR158 4.7 101.9 1.0 CA 0:TYR158 4.8 101.9 1.0 CG2 0:THR137 4.9 144.2 1.0 CB 0:HIS159 4.9 57.3 1.0 OG1 0:THR137 5.0 144.2 1.0 CA 0:HIS159 5.0 57.3 1.0

C.Yang, R.Fujiwara, H.J.Kim, P.Basnet, Y.Zhu, J.J.Gorbea Colon, S.Steimle, B.A.Garcia, C.D.Kaplan, K.Murakami. Structural Visualization of De Novo Transcription Initiation By Saccharomyces Cerevisiae Rna Polymerase II. Mol.Cell V. 82 660 2022.
ISSN: ISSN 1097-2765
PubMed: 35051353
DOI: 10.1016/J.MOLCEL.2021.12.020