Iron in PDB 7nvx: Tfiih in A Post-Translocated State (with Adp-BEF3)

All present enzymatic activity of Tfiih in A Post-Translocated State (with Adp-BEF3):
3.6.4.12;

The structure of Tfiih in A Post-Translocated State (with Adp-BEF3) also contains other interesting chemical elements:

Fluorine	(F)	3 atoms
Magnesium	(Mg)	1 atom
Zinc	(Zn)	7 atoms

The binding sites of Iron atom in the Tfiih in A Post-Translocated State (with Adp-BEF3) (pdb code 7nvx). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Tfiih in A Post-Translocated State (with Adp-BEF3), PDB code: 7nvx:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Tfiih in A Post-Translocated State (with Adp-BEF3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Tfiih in A Post-Translocated State (with Adp-BEF3) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:145.9 occ:1.00 FE1 0:SF41000 0.0 145.9 1.0 SG 0:CYS190 2.2 68.3 1.0 S4 0:SF41000 2.3 145.9 1.0 S3 0:SF41000 2.3 145.9 1.0 S2 0:SF41000 2.3 145.9 1.0 FE4 0:SF41000 2.7 145.9 1.0 FE3 0:SF41000 2.7 145.9 1.0 FE2 0:SF41000 2.7 145.9 1.0 CB 0:CYS190 3.6 68.3 1.0 S1 0:SF41000 3.9 145.9 1.0 CE2 0:PHE193 4.0 64.8 1.0 CD2 0:PHE193 4.1 64.8 1.0 CA 0:CYS190 4.3 68.3 1.0 SG 0:CYS155 4.6 69.3 1.0 CB 0:PHE157 4.6 67.5 1.0 CB 0:TYR158 4.7 69.2 1.0 SG 0:CYS134 4.8 54.2 1.0 N 0:TYR158 4.8 69.2 1.0 SG 0:CYS116 4.8 64.0 1.0

Iron binding site 2 out of 4 in the Tfiih in A Post-Translocated State (with Adp-BEF3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Tfiih in A Post-Translocated State (with Adp-BEF3) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:145.9 occ:1.00 FE2 0:SF41000 0.0 145.9 1.0 SG 0:CYS116 2.3 64.0 1.0 S3 0:SF41000 2.3 145.9 1.0 S4 0:SF41000 2.3 145.9 1.0 S1 0:SF41000 2.3 145.9 1.0 FE3 0:SF41000 2.7 145.9 1.0 FE4 0:SF41000 2.7 145.9 1.0 FE1 0:SF41000 2.7 145.9 1.0 CB 0:HIS118 3.8 66.3 1.0 CB 0:CYS116 3.8 64.0 1.0 S2 0:SF41000 3.9 145.9 1.0 N 0:HIS118 4.2 66.3 1.0 N 0:ILE117 4.4 64.2 1.0 CA 0:CYS116 4.6 64.0 1.0 CA 0:HIS118 4.7 66.3 1.0 SG 0:CYS134 4.7 54.2 1.0 SG 0:CYS155 4.8 69.3 1.0 CG2 0:VAL121 4.8 60.2 1.0 SG 0:CYS190 4.8 68.3 1.0 CG 0:HIS118 4.8 66.3 1.0

Iron binding site 3 out of 4 in the Tfiih in A Post-Translocated State (with Adp-BEF3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Tfiih in A Post-Translocated State (with Adp-BEF3) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:145.9 occ:1.00 FE3 0:SF41000 0.0 145.9 1.0 SG 0:CYS134 2.3 54.2 1.0 S2 0:SF41000 2.3 145.9 1.0 S1 0:SF41000 2.3 145.9 1.0 S4 0:SF41000 2.3 145.9 1.0 FE2 0:SF41000 2.7 145.9 1.0 FE1 0:SF41000 2.7 145.9 1.0 FE4 0:SF41000 2.7 145.9 1.0 CB 0:CYS134 3.4 54.2 1.0 S3 0:SF41000 3.9 145.9 1.0 CA 0:CYS134 4.1 54.2 1.0 CE2 0:PHE193 4.2 64.8 1.0 SG 0:CYS116 4.7 64.0 1.0 O 0:CYS134 4.7 54.2 1.0 SG 0:CYS190 4.8 68.3 1.0 SG 0:CYS155 4.8 69.3 1.0 C 0:CYS134 4.8 54.2 1.0 CZ 0:PHE193 5.0 64.8 1.0

Iron binding site 4 out of 4 in the Tfiih in A Post-Translocated State (with Adp-BEF3)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Tfiih in A Post-Translocated State (with Adp-BEF3) within 5.0Å range: probe atom residue distance (Å) B Occ 0:Fe1000 b:145.9 occ:1.00 FE4 0:SF41000 0.0 145.9 1.0 SG 0:CYS155 2.2 69.3 1.0 S2 0:SF41000 2.3 145.9 1.0 S1 0:SF41000 2.3 145.9 1.0 S3 0:SF41000 2.3 145.9 1.0 FE1 0:SF41000 2.7 145.9 1.0 FE2 0:SF41000 2.7 145.9 1.0 FE3 0:SF41000 2.7 145.9 1.0 CB 0:CYS155 3.7 69.3 1.0 S4 0:SF41000 3.9 145.9 1.0 CB 0:HIS118 3.9 66.3 1.0 ND1 0:HIS118 3.9 66.3 1.0 CG 0:HIS118 4.1 66.3 1.0 CD2 0:PHE157 4.2 67.5 1.0 SG 0:CYS190 4.6 68.3 1.0 SG 0:CYS116 4.8 64.0 1.0 CE1 0:HIS118 4.8 66.3 1.0 CB 0:PHE157 4.8 67.5 1.0 SG 0:CYS134 4.8 54.2 1.0 CA 0:CYS155 5.0 69.3 1.0

S.Aibara, S.Schilbach, P.Cramer. Structures of Mammalian Rna Polymerase II Pre-Initiation Complexes. Nature 2021.
ISSN: ESSN 1476-4687
PubMed: 33902107
DOI: 10.1038/S41586-021-03554-8