Iron in PDB 7o64: Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 1 Minute.

All present enzymatic activity of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 1 Minute.:
1.16.3.1;

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 1 Minute., PDB code: 7o64 was solved by C.Pozzi, S.Ciambellotti, G.Tassone, P.Turano, S.Mangani, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	55.59 / 1.96
Space group	F 4 3 2
Cell size a, b, c (Å), α, β, γ (°)	184.168, 184.168, 184.168, 90, 90, 90
R / Rfree (%)	16.3 / 20.4

The structure of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 1 Minute. also contains other interesting chemical elements:

Chlorine	(Cl)	1 atom
Magnesium	(Mg)	1 atom

The binding sites of Iron atom in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 1 Minute. (pdb code 7o64). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 1 Minute., PDB code: 7o64:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 1 Minute.


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 1 Minute. within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe201 b:33.1 occ:0.50 O A:HOH342 2.0 36.2 1.0 OE1 A:GLU62 2.0 27.7 1.0 OE2 A:GLU27 2.0 31.5 1.0 ND1 A:HIS65 2.2 31.9 1.0 O A:HOH344 2.2 30.3 1.0 CE1 A:HIS65 3.0 33.4 1.0 CD A:GLU62 3.0 28.5 1.0 CD A:GLU27 3.0 29.8 1.0 CG A:HIS65 3.3 33.0 1.0 OE1 A:GLU27 3.4 28.2 1.0 OE2 A:GLU62 3.4 29.0 1.0 CB A:HIS65 3.7 25.3 1.0 O A:HOH467 4.1 48.4 1.0 OE1 A:GLN141 4.2 37.3 1.0 NE2 A:HIS65 4.2 38.3 1.0 CG1 A:VAL110 4.3 25.5 1.0 CG A:GLU27 4.4 25.7 1.0 CG A:GLU62 4.4 25.0 1.0 CD2 A:HIS65 4.4 34.4 1.0 CA A:GLU62 4.6 23.6 1.0 CB A:GLU62 4.7 23.4 1.0 CB A:GLU27 4.7 25.1 1.0 O A:HOH324 4.8 20.0 0.5 CA A:GLU27 4.9 23.8 1.0

Iron binding site 2 out of 2 in the Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 1 Minute.


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Crystal Structure of Human Mitochondrial Ferritin (Hmtf) Fe(II)-Loaded For 1 Minute. within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe202 b:38.3 occ:0.20 O A:HOH510 2.1 23.3 1.0 O A:HOH343 2.2 27.4 1.0 OE2 A:GLU134 4.0 30.2 1.0 O A:HOH551 4.2 26.2 1.0 O A:HOH323 4.3 38.6 1.0 OE1 A:GLU134 4.3 44.9 1.0 CD A:GLU134 4.6 31.2 1.0

S.Ciambellotti, A.Pratesi, G.Tassone, P.Turano, S.Mangani, C.Pozzi. Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin. Chemistry 2021.
ISSN: ISSN 0947-6539
PubMed: 34343376
DOI: 10.1002/CHEM.202102270