Iron in PDB 8brc: Crystal Structure of the Adduct Between Human Serum Transferrin and Cisplatin

The structure of Crystal Structure of the Adduct Between Human Serum Transferrin and Cisplatin, PDB code: 8brc was solved by R.Troisi, F.Galardo, G.Ferraro, F.Sica, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	102.77 / 3.17
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	136.34, 156.4, 107.44, 90, 90, 90
R / Rfree (%)	17.7 / 24.3

The structure of Crystal Structure of the Adduct Between Human Serum Transferrin and Cisplatin also contains other interesting chemical elements:

Platinum

(Pt)

1 atom

The binding sites of Iron atom in the Crystal Structure of the Adduct Between Human Serum Transferrin and Cisplatin (pdb code 8brc). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Crystal Structure of the Adduct Between Human Serum Transferrin and Cisplatin, PDB code: 8brc:

Iron binding site 1 out of 1 in the Crystal Structure of the Adduct Between Human Serum Transferrin and Cisplatin


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Crystal Structure of the Adduct Between Human Serum Transferrin and Cisplatin within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe701 b:106.8 occ:1.00 O7 A:MLI702 2.0 100.7 1.0 O9 A:MLI702 2.0 103.2 1.0 OH A:TYR517 2.0 114.3 1.0 NE2 A:HIS585 2.2 111.8 1.0 OH A:TYR426 2.3 137.4 1.0 OD1 A:ASP392 2.5 103.1 1.0 C2 A:MLI702 3.0 99.9 1.0 CD2 A:HIS585 3.0 115.2 1.0 C3 A:MLI702 3.0 103.7 1.0 CZ A:TYR426 3.1 134.2 1.0 CZ A:TYR517 3.2 114.8 1.0 CE1 A:HIS585 3.3 109.4 1.0 CG A:ASP392 3.4 103.8 1.0 C1 A:MLI702 3.5 99.8 1.0 CE2 A:TYR426 3.7 126.1 1.0 CE1 A:TYR517 3.8 108.9 1.0 O6 A:MLI702 4.1 94.3 1.0 CE1 A:TYR426 4.1 136.9 1.0 CB A:ASP392 4.1 99.0 1.0 O8 A:MLI702 4.1 102.3 1.0 OD2 A:ASP392 4.1 98.7 1.0 CE2 A:TYR517 4.2 113.4 1.0 CG A:HIS585 4.2 118.8 1.0 CB A:THR457 4.2 100.5 1.0 ND1 A:HIS585 4.4 114.4 1.0 O A:HOH826 4.5 86.2 1.0 OG1 A:THR457 4.6 100.7 1.0 CA A:ASP392 4.6 101.1 1.0 N A:ALA458 4.8 109.7 1.0 CD2 A:TYR426 4.9 130.7 1.0 N A:THR457 4.9 94.3 1.0 N A:GLY393 5.0 100.2 1.0

R.Troisi, F.Galardo, G.Ferraro, F.Sica, A.Merlino. Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study. Inorg.Chem. 2023.
ISSN: ISSN 0020-1669
PubMed: 36602395
DOI: 10.1021/ACS.INORGCHEM.2C04206