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Iron in PDB 8d3l: Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer

Enzymatic activity of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer

All present enzymatic activity of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer:
3.1.12.1;

Other elements in 8d3l:

The structure of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer also contains other interesting chemical elements:

Manganese (Mn) 2 atoms

Iron Binding Sites:

The binding sites of Iron atom in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer (pdb code 8d3l). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 8 binding sites of Iron where determined in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer, PDB code: 8d3l:
Jump to Iron binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Iron binding site 1 out of 8 in 8d3l

Go back to Iron Binding Sites List in 8d3l
Iron binding site 1 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:54.6
occ:1.00
 FE1 I:SF4301 0.0 54.6 1.0
SG I:CYS190 1.0 10.1 1.0
S2 I:SF4301 2.3 54.6 1.0
S3 I:SF4301 2.3 54.6 1.0
S4 I:SF4301 2.3 54.6 1.0
FE4 I:SF4301 2.7 54.6 1.0
FE3 I:SF4301 2.7 54.6 1.0
FE2 I:SF4301 2.7 54.6 1.0
CB I:CYS190 2.8 10.1 1.0
SG I:CYS21 2.9 8.7 1.0
S1 I:SF4301 3.9 54.6 1.0
CA I:CYS190 3.9 10.1 1.0
N I:CYS190 4.2 10.1 1.0
CB I:CYS21 4.3 8.7 1.0
SG I:CYS199 4.5 7.8 1.0
SG I:CYS193 4.5 10.9 1.0
CG1 I:VAL184 4.7 8.7 1.0
CB I:CYS193 4.9 10.9 1.0
O I:THR186 4.9 9.9 1.0

Iron binding site 2 out of 8 in 8d3l

Go back to Iron Binding Sites List in 8d3l
Iron binding site 2 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:54.6
occ:1.00
 FE2 I:SF4301 0.0 54.6 1.0
SG I:CYS190 2.2 10.1 1.0
S1 I:SF4301 2.3 54.6 1.0
S4 I:SF4301 2.3 54.6 1.0
S3 I:SF4301 2.3 54.6 1.0
SG I:CYS199 2.4 7.8 1.0
CB I:CYS190 2.6 10.1 1.0
SG I:CYS193 2.7 10.9 1.0
FE3 I:SF4301 2.7 54.6 1.0
FE4 I:SF4301 2.7 54.6 1.0
FE1 I:SF4301 2.7 54.6 1.0
CB I:CYS193 2.9 10.9 1.0
CA I:CYS190 3.6 10.1 1.0
CG I:PRO201 3.8 8.7 1.0
S2 I:SF4301 3.9 54.6 1.0
CB I:CYS199 4.1 7.8 1.0
CA I:CYS193 4.4 10.9 1.0
O I:CYS190 4.4 10.1 1.0
C I:CYS190 4.4 10.1 1.0
CA I:GLN196 4.4 7.5 1.0
CD I:PRO201 4.6 8.7 1.0
SG I:CYS21 4.7 8.7 1.0
N I:CYS190 4.8 10.1 1.0
CG I:GLN196 4.8 7.5 1.0
CB I:GLN196 4.8 7.5 1.0
CB I:PRO201 4.8 8.7 1.0
N I:GLN196 4.9 7.5 1.0
O I:LEU195 5.0 5.7 1.0

Iron binding site 3 out of 8 in 8d3l

Go back to Iron Binding Sites List in 8d3l
Iron binding site 3 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:54.6
occ:1.00
 FE3 I:SF4301 0.0 54.6 1.0
S4 I:SF4301 2.3 54.6 1.0
S1 I:SF4301 2.3 54.6 1.0
S2 I:SF4301 2.3 54.6 1.0
SG I:CYS199 2.6 7.8 1.0
FE2 I:SF4301 2.7 54.6 1.0
FE1 I:SF4301 2.7 54.6 1.0
FE4 I:SF4301 2.7 54.6 1.0
CB I:CYS199 3.1 7.8 1.0
SG I:CYS190 3.2 10.1 1.0
SG I:CYS21 3.5 8.7 1.0
S3 I:SF4301 3.9 54.6 1.0
CD I:ARG23 4.2 6.5 1.0
SG I:CYS193 4.2 10.9 1.0
O I:CYS199 4.3 7.8 1.0
CB I:ARG23 4.3 6.5 1.0
CA I:CYS199 4.4 7.8 1.0
C I:CYS199 4.5 7.8 1.0
CB I:CYS190 4.5 10.1 1.0
CG I:ARG23 4.6 6.5 1.0
CG I:PRO201 4.7 8.7 1.0
NE I:ARG23 5.0 6.5 1.0

Iron binding site 4 out of 8 in 8d3l

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Iron binding site 4 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Fe301

b:54.6
occ:1.00
 FE4 I:SF4301 0.0 54.6 1.0
S3 I:SF4301 2.3 54.6 1.0
S2 I:SF4301 2.3 54.6 1.0
S1 I:SF4301 2.3 54.6 1.0
SG I:CYS21 2.6 8.7 1.0
SG I:CYS193 2.6 10.9 1.0
FE1 I:SF4301 2.7 54.6 1.0
FE2 I:SF4301 2.7 54.6 1.0
FE3 I:SF4301 2.7 54.6 1.0
SG I:CYS190 2.9 10.1 1.0
CB I:CYS21 3.5 8.7 1.0
SG I:CYS199 3.6 7.8 1.0
CB I:CYS193 3.8 10.9 1.0
S4 I:SF4301 3.9 54.6 1.0
NE2 I:GLN24 4.0 5.7 1.0
CB I:GLN24 4.0 5.7 1.0
CG I:GLN24 4.3 5.7 1.0
CB I:CYS190 4.4 10.1 1.0
CB I:CYS199 4.5 7.8 1.0
N I:GLN24 4.6 5.7 1.0
CA I:GLN24 4.6 5.7 1.0
CD I:GLN24 4.6 5.7 1.0
CA I:CYS193 4.9 10.9 1.0
CA I:CYS21 5.0 8.7 1.0

Iron binding site 5 out of 8 in 8d3l

Go back to Iron Binding Sites List in 8d3l
Iron binding site 5 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 5 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Fe301

b:10.7
occ:1.00
 FE1 J:SF4301 0.0 10.7 1.0
SG J:CYS21 2.3 3.3 1.0
S2 J:SF4301 2.3 10.7 1.0
S4 J:SF4301 2.3 10.7 1.0
S3 J:SF4301 2.3 10.7 1.0
SG J:CYS199 2.4 4.3 1.0
FE2 J:SF4301 2.7 10.7 1.0
FE3 J:SF4301 2.7 10.7 1.0
FE4 J:SF4301 2.7 10.7 1.0
SG J:CYS190 3.6 5.5 1.0
S1 J:SF4301 3.9 10.7 1.0
CB J:CYS199 4.0 4.3 1.0
CB J:CYS21 4.1 3.3 1.0
CB J:ARG23 4.1 1.8 1.0
SG J:CYS193 4.3 3.4 1.0
CD J:ARG23 4.5 1.8 1.0
CG J:ARG23 4.8 1.8 1.0
O J:CYS21 4.8 3.3 1.0
N J:GLN24 4.8 2.2 1.0
CB J:CYS190 4.9 5.5 1.0
CA J:CYS21 4.9 3.3 1.0
CG2 J:VAL184 4.9 5.4 1.0

Iron binding site 6 out of 8 in 8d3l

Go back to Iron Binding Sites List in 8d3l
Iron binding site 6 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 6 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Fe301

b:10.7
occ:1.00
 FE2 J:SF4301 0.0 10.7 1.0
S1 J:SF4301 2.3 10.7 1.0
SG J:CYS199 2.3 4.3 1.0
S4 J:SF4301 2.3 10.7 1.0
S3 J:SF4301 2.3 10.7 1.0
CB J:CYS199 2.4 4.3 1.0
SG J:CYS193 2.5 3.4 1.0
FE3 J:SF4301 2.7 10.7 1.0
FE1 J:SF4301 2.7 10.7 1.0
FE4 J:SF4301 2.7 10.7 1.0
S2 J:SF4301 3.9 10.7 1.0
CA J:CYS199 3.9 4.3 1.0
SG J:CYS21 4.0 3.3 1.0
CB J:CYS193 4.0 3.4 1.0
O J:LEU195 4.1 2.5 1.0
SG J:CYS190 4.2 5.5 1.0
C J:LEU195 4.3 2.5 1.0
C J:CYS199 4.5 4.3 1.0
CG J:PRO201 4.5 6.9 1.0
N J:GLN196 4.6 5.0 1.0
CB J:LEU195 4.6 2.5 1.0
N J:CYS199 4.6 4.3 1.0
CB J:CYS190 4.6 5.5 1.0
CA J:GLN196 4.7 5.0 1.0
CA J:LEU195 4.9 2.5 1.0

Iron binding site 7 out of 8 in 8d3l

Go back to Iron Binding Sites List in 8d3l
Iron binding site 7 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 7 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Fe301

b:10.7
occ:1.00
 FE3 J:SF4301 0.0 10.7 1.0
S1 J:SF4301 2.3 10.7 1.0
SG J:CYS193 2.3 3.4 1.0
S4 J:SF4301 2.3 10.7 1.0
S2 J:SF4301 2.3 10.7 1.0
SG J:CYS190 2.3 5.5 1.0
SG J:CYS21 2.3 3.3 1.0
FE4 J:SF4301 2.7 10.7 1.0
FE2 J:SF4301 2.7 10.7 1.0
FE1 J:SF4301 2.7 10.7 1.0
CB J:CYS193 2.9 3.4 1.0
CB J:CYS21 3.4 3.3 1.0
CB J:CYS190 3.4 5.5 1.0
S3 J:SF4301 3.9 10.7 1.0
CA J:CYS190 4.0 5.5 1.0
SG J:CYS199 4.2 4.3 1.0
CA J:CYS193 4.4 3.4 1.0
CA J:CYS21 4.8 3.3 1.0
CZ J:PHE20 4.9 2.7 1.0
N J:CYS193 4.9 3.4 1.0
N J:CYS190 4.9 5.5 1.0
O J:CYS190 5.0 5.5 1.0
C J:CYS190 5.0 5.5 1.0

Iron binding site 8 out of 8 in 8d3l

Go back to Iron Binding Sites List in 8d3l
Iron binding site 8 out of 8 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 8 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Fe301

b:10.7
occ:1.00
 FE4 J:SF4301 0.0 10.7 1.0
S3 J:SF4301 2.3 10.7 1.0
S2 J:SF4301 2.3 10.7 1.0
S1 J:SF4301 2.3 10.7 1.0
SG J:CYS190 2.3 5.5 1.0
CB J:CYS190 2.6 5.5 1.0
FE3 J:SF4301 2.7 10.7 1.0
FE1 J:SF4301 2.7 10.7 1.0
FE2 J:SF4301 2.7 10.7 1.0
CG J:PRO201 3.3 6.9 1.0
SG J:CYS193 3.5 3.4 1.0
SG J:CYS199 3.5 4.3 1.0
CB J:PRO201 3.5 6.9 1.0
S4 J:SF4301 3.9 10.7 1.0
CA J:CYS190 4.0 5.5 1.0
SG J:CYS21 4.0 3.3 1.0
CA J:PRO201 4.2 6.9 1.0
O J:CYS190 4.3 5.5 1.0
CD J:PRO201 4.4 6.9 1.0
CB J:CYS199 4.4 4.3 1.0
N J:PRO201 4.6 6.9 1.0
C J:CYS190 4.7 5.5 1.0

Reference:

Y.Dhingra, S.K.Suresh, P.Juneja, D.G.Sashital. Pam Binding Ensures Orientational Integration During CAS4-CAS1-CAS2-Mediated Crispr Adaptation. Mol.Cell V. 82 4353 2022.
ISSN: ISSN 1097-2765
PubMed: 36272411
DOI: 10.1016/J.MOLCEL.2022.09.030
Page generated: Fri Aug 9 23:14:55 2024

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