Iron in PDB 8iue: Rna Polymerase III Pre-Initiation Complex Melting Complex 1

All present enzymatic activity of Rna Polymerase III Pre-Initiation Complex Melting Complex 1:
2.7.7.6;

The structure of Rna Polymerase III Pre-Initiation Complex Melting Complex 1 also contains other interesting chemical elements:

Zinc	(Zn)	8 atoms
Magnesium	(Mg)	1 atom

The binding sites of Iron atom in the Rna Polymerase III Pre-Initiation Complex Melting Complex 1 (pdb code 8iue). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Rna Polymerase III Pre-Initiation Complex Melting Complex 1, PDB code: 8iue:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Rna Polymerase III Pre-Initiation Complex Melting Complex 1


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Rna Polymerase III Pre-Initiation Complex Melting Complex 1 within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:124.6 occ:1.00 FE1 P:SF4401 0.0 124.6 1.0 S2 P:SF4401 2.3 124.6 1.0 S3 P:SF4401 2.3 124.6 1.0 S4 P:SF4401 2.3 124.6 1.0 FE4 P:SF4401 2.7 124.6 1.0 FE2 P:SF4401 2.7 124.6 1.0 FE3 P:SF4401 2.7 124.6 1.0 SG P:CYS290 3.0 112.9 1.0 CB P:CYS290 3.5 112.9 1.0 S1 P:SF4401 3.9 124.6 1.0 CD2 P:TYR309 4.1 125.2 1.0 SG P:CYS307 4.5 128.5 1.0 CE2 P:TYR309 4.6 125.2 1.0 O P:PRO286 4.7 123.7 1.0 CA P:CYS287 4.8 128.7 1.0 CG P:TYR309 4.9 125.2 1.0 CA P:CYS290 4.9 112.9 1.0

Iron binding site 2 out of 4 in the Rna Polymerase III Pre-Initiation Complex Melting Complex 1


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Rna Polymerase III Pre-Initiation Complex Melting Complex 1 within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:124.6 occ:1.00 FE2 P:SF4401 0.0 124.6 1.0 S4 P:SF4401 2.3 124.6 1.0 S1 P:SF4401 2.3 124.6 1.0 S3 P:SF4401 2.3 124.6 1.0 FE4 P:SF4401 2.7 124.6 1.0 FE3 P:SF4401 2.7 124.6 1.0 FE1 P:SF4401 2.7 124.6 1.0 SG P:CYS296 3.2 125.2 1.0 CB P:CYS296 3.3 125.2 1.0 ND2 O:ASN445 3.9 131.3 1.0 S2 P:SF4401 3.9 124.6 1.0 CA P:CYS296 4.2 125.2 1.0 CG2 P:ILE302 4.4 124.8 1.0 N P:CYS296 5.0 125.2 1.0 CG O:ASN445 5.0 131.3 1.0

Iron binding site 3 out of 4 in the Rna Polymerase III Pre-Initiation Complex Melting Complex 1


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Rna Polymerase III Pre-Initiation Complex Melting Complex 1 within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:124.6 occ:1.00 FE3 P:SF4401 0.0 124.6 1.0 S1 P:SF4401 2.3 124.6 1.0 S4 P:SF4401 2.3 124.6 1.0 S2 P:SF4401 2.3 124.6 1.0 FE4 P:SF4401 2.7 124.6 1.0 FE2 P:SF4401 2.7 124.6 1.0 FE1 P:SF4401 2.7 124.6 1.0 SG P:CYS287 3.0 128.7 1.0 CB P:CYS287 3.2 128.7 1.0 CA P:CYS287 3.3 128.7 1.0 ND2 O:ASN445 3.6 131.3 1.0 S3 P:SF4401 3.9 124.6 1.0 N P:CYS287 4.1 128.7 1.0 C P:CYS287 4.4 128.7 1.0 O P:CYS287 4.5 128.7 1.0 CG O:ASN445 4.6 131.3 1.0 CB O:ASN445 4.6 131.3 1.0 C P:PRO286 4.8 123.7 1.0 CD1 P:PHE293 4.8 117.8 1.0 O P:PRO286 4.8 123.7 1.0 SG P:CYS296 4.8 125.2 1.0 CB P:CYS290 4.8 112.9 1.0

Iron binding site 4 out of 4 in the Rna Polymerase III Pre-Initiation Complex Melting Complex 1


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Rna Polymerase III Pre-Initiation Complex Melting Complex 1 within 5.0Å range: probe atom residue distance (Å) B Occ P:Fe401 b:124.6 occ:1.00 FE4 P:SF4401 0.0 124.6 1.0 S1 P:SF4401 2.3 124.6 1.0 S2 P:SF4401 2.3 124.6 1.0 S3 P:SF4401 2.3 124.6 1.0 FE2 P:SF4401 2.7 124.6 1.0 FE3 P:SF4401 2.7 124.6 1.0 FE1 P:SF4401 2.7 124.6 1.0 SG P:CYS307 3.0 128.5 1.0 CB P:CYS307 3.4 128.5 1.0 S4 P:SF4401 3.9 124.6 1.0 CA P:PRO304 4.2 122.9 1.0 CG P:MET310 4.3 133.9 1.0 CA P:CYS307 4.7 128.5 1.0 CB P:PRO304 4.7 122.9 1.0 SG P:CYS287 4.7 128.7 1.0 O P:SER303 4.7 122.8 1.0 N P:PRO304 4.8 122.9 1.0

H.Hou, Q.Jin, Y.Ren, Z.Chen, Q.Wang, Y.Xu. Structure of the Snapc-Bound Rna Polymerase III Preinitiation Complex. Cell Res. 2023.
ISSN: ISSN 1001-0602
PubMed: 37165065
DOI: 10.1038/S41422-023-00819-X