Iron in PDB 8rmd: Structure of the FDX2-Bound Core Isc Complex (Distal Conformation)

All present enzymatic activity of Structure of the FDX2-Bound Core Isc Complex (Distal Conformation):
2.8.1.7;

The binding sites of Iron atom in the Structure of the FDX2-Bound Core Isc Complex (Distal Conformation) (pdb code 8rmd). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Structure of the FDX2-Bound Core Isc Complex (Distal Conformation), PDB code: 8rmd:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Structure of the FDX2-Bound Core Isc Complex (Distal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of the FDX2-Bound Core Isc Complex (Distal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ D:Fe201 b:133.8 occ:1.00 OD1 D:ASP71 2.2 72.2 1.0 NE2 D:HIS137 2.2 121.8 1.0 SG A:CYS381 2.3 163.5 1.0 OD2 D:ASP71 2.4 73.9 1.0 CG D:ASP71 2.6 72.6 1.0 CD2 D:HIS137 3.2 121.8 1.0 CE1 D:HIS137 3.2 121.4 1.0 SG D:CYS95 3.5 36.6 1.0 CB A:CYS381 3.8 163.3 1.0 CB D:ASP71 4.1 71.2 1.0 CG D:HIS137 4.3 121.8 1.0 ND1 D:HIS137 4.3 121.6 1.0 SG D:CYS138 4.4 90.6 1.0 CB D:CYS95 4.5 31.2 1.0 N D:CYS95 4.6 27.5 1.0 O D:GLY70 4.9 75.3 1.0 CA A:CYS381 4.9 163.9 1.0

Iron binding site 2 out of 4 in the Structure of the FDX2-Bound Core Isc Complex (Distal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Structure of the FDX2-Bound Core Isc Complex (Distal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ I:Fe201 b:126.3 occ:1.00 FE1 I:FES201 0.0 126.3 1.0 SG I:CYS114 2.2 118.9 1.0 S2 I:FES201 2.2 126.4 1.0 S1 I:FES201 2.2 125.3 1.0 SG I:CYS108 2.3 160.1 1.0 CB I:CYS108 3.0 160.3 1.0 FE2 I:FES201 3.0 124.4 1.0 N I:CYS108 3.3 159.9 1.0 CB I:CYS114 3.4 119.3 1.0 CA I:CYS108 3.6 160.5 1.0 N I:CYS114 3.7 118.6 1.0 C I:CYS108 3.9 160.6 1.0 CA I:CYS114 4.0 118.9 1.0 N I:ALA110 4.0 132.0 1.0 N I:GLU109 4.1 168.1 1.0 SG I:CYS117 4.2 95.4 1.0 N I:SER115 4.4 103.7 1.0 N I:ALA113 4.5 90.0 1.0 N I:ALA107 4.5 120.0 1.0 C I:ALA107 4.5 121.0 1.0 CA I:ALA110 4.6 131.4 1.0 O I:CYS108 4.6 160.9 1.0 N I:SER111 4.6 123.8 1.0 C I:CYS114 4.6 118.7 1.0 OG1 I:THR116 4.7 79.2 1.0 N I:LEU112 4.7 112.3 1.0 C I:GLY106 4.7 108.5 1.0 C I:ALA113 4.8 89.8 1.0 CA I:GLY106 4.9 108.1 1.0 N I:THR116 4.9 78.1 1.0 SG I:CYS154 5.0 101.5 1.0 C I:GLU109 5.0 168.2 1.0

Iron binding site 3 out of 4 in the Structure of the FDX2-Bound Core Isc Complex (Distal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Structure of the FDX2-Bound Core Isc Complex (Distal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ I:Fe201 b:124.4 occ:1.00 FE2 I:FES201 0.0 124.4 1.0 SG I:CYS154 2.1 101.5 1.0 SG I:CYS117 2.2 95.4 1.0 S1 I:FES201 2.2 125.3 1.0 S2 I:FES201 2.2 126.4 1.0 FE1 I:FES201 3.0 126.3 1.0 CB I:CYS154 3.2 101.5 1.0 CB I:CYS117 3.4 95.3 1.0 CA I:ALA110 4.2 131.4 1.0 N I:CYS154 4.4 100.0 1.0 CA I:CYS154 4.4 101.1 1.0 N I:ALA110 4.5 132.0 1.0 SG I:CYS114 4.5 118.9 1.0 SG I:CYS108 4.6 160.1 1.0 CB I:LEU152 4.6 51.9 1.0 CA I:CYS117 4.7 94.7 1.0 N I:CYS117 4.7 94.4 1.0 CD1 I:LEU152 4.7 53.1 1.0 N I:LEU112 5.0 112.3 1.0

Iron binding site 4 out of 4 in the Structure of the FDX2-Bound Core Isc Complex (Distal Conformation)


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Structure of the FDX2-Bound Core Isc Complex (Distal Conformation) within 5.0Å range: probe atom residue distance (Å) B Occ H:Fe201 b:115.3 occ:1.00 OD2 H:ASP71 2.0 25.8 1.0 NE2 H:HIS137 2.2 22.1 1.0 SG E:CYS381 2.3 51.5 1.0 SG H:CYS95 2.3 28.5 1.0 CG H:ASP71 2.9 22.9 1.0 OD1 H:ASP71 3.1 23.4 1.0 CD2 H:HIS137 3.1 20.5 1.0 CE1 H:HIS137 3.2 19.0 1.0 CB H:CYS95 3.5 16.0 1.0 SG H:CYS138 3.7 23.8 1.0 CB E:CYS381 3.9 51.0 1.0 SG H:CYS69 4.0 45.1 1.0 N H:CYS95 4.1 13.6 1.0 ND1 H:HIS137 4.3 18.4 1.0 CG H:HIS137 4.3 20.1 1.0 CB H:ASP71 4.3 21.7 1.0 CA H:CYS95 4.4 14.2 1.0 CB H:ALA98 4.4 13.2 1.0

R.Steinhilper, L.Boss, S.A.Freibert, V.Schulz, N.Krapoth, S.Kaltwasser, R.Lill, B.J.Murphy. Two-Stage Binding of Mitochondrial Ferredoxin-2 to the Core Iron-Sulfur Cluster Assembly Complex. Nat Commun V. 15 10559 2024.
ISSN: ESSN 2041-1723
PubMed: 39632806
DOI: 10.1038/S41467-024-54585-4