Iron in PDB 8s5i: Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction
Enzymatic activity of Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction
All present enzymatic activity of Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction:
4.2.1.22;
Iron Binding Sites:
The binding sites of Iron atom in the Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction
(pdb code 8s5i). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 6 binding sites of Iron where determined in the
Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction, PDB code: 8s5i:
Jump to Iron binding site number:
1;
2;
3;
4;
5;
6;
Iron binding site 1 out
of 6 in 8s5i
Go back to
Iron Binding Sites List in 8s5i
Iron binding site 1 out
of 6 in the Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Fe601
b:85.4
occ:1.00
|
FE
|
A:HEM601
|
0.0
|
85.4
|
1.0
|
|
NC
|
A:HEM601
|
2.0
|
58.1
|
1.0
|
|
NA
|
A:HEM601
|
2.0
|
62.7
|
1.0
|
|
NB
|
A:HEM601
|
2.0
|
57.6
|
1.0
|
|
ND
|
A:HEM601
|
2.0
|
57.9
|
1.0
|
|
HG
|
A:CYS52
|
2.4
|
60.7
|
1.0
|
|
NE2
|
A:HIS65
|
2.7
|
49.5
|
1.0
|
|
C1D
|
A:HEM601
|
3.0
|
57.4
|
1.0
|
|
C4C
|
A:HEM601
|
3.0
|
51.8
|
1.0
|
|
C4A
|
A:HEM601
|
3.0
|
61.0
|
1.0
|
|
C1B
|
A:HEM601
|
3.0
|
56.1
|
1.0
|
|
C4D
|
A:HEM601
|
3.0
|
58.6
|
1.0
|
|
C1A
|
A:HEM601
|
3.0
|
59.4
|
1.0
|
|
C1C
|
A:HEM601
|
3.0
|
54.3
|
1.0
|
|
C4B
|
A:HEM601
|
3.1
|
58.5
|
1.0
|
|
SG
|
A:CYS52
|
3.2
|
63.7
|
1.0
|
|
HB2
|
A:CYS52
|
3.3
|
59.5
|
1.0
|
|
CHB
|
A:HEM601
|
3.4
|
58.2
|
1.0
|
|
CHD
|
A:HEM601
|
3.4
|
55.5
|
1.0
|
|
HD2
|
A:HIS65
|
3.4
|
50.8
|
1.0
|
|
CHA
|
A:HEM601
|
3.4
|
62.9
|
1.0
|
|
CHC
|
A:HEM601
|
3.4
|
56.6
|
1.0
|
|
CD2
|
A:HIS65
|
3.4
|
46.3
|
1.0
|
|
CB
|
A:CYS52
|
3.7
|
59.6
|
1.0
|
|
CE1
|
A:HIS65
|
3.8
|
53.8
|
1.0
|
|
HA
|
A:CYS52
|
3.8
|
59.8
|
1.0
|
|
HE1
|
A:HIS65
|
4.0
|
51.4
|
1.0
|
|
C2D
|
A:HEM601
|
4.2
|
55.4
|
1.0
|
|
C3D
|
A:HEM601
|
4.2
|
54.8
|
1.0
|
|
C3A
|
A:HEM601
|
4.2
|
58.6
|
1.0
|
|
HB2
|
A:TRP54
|
4.2
|
58.0
|
1.0
|
|
C2A
|
A:HEM601
|
4.2
|
55.2
|
1.0
|
|
C3C
|
A:HEM601
|
4.2
|
51.3
|
1.0
|
|
C2C
|
A:HEM601
|
4.2
|
52.4
|
1.0
|
|
C2B
|
A:HEM601
|
4.3
|
58.6
|
1.0
|
|
C3B
|
A:HEM601
|
4.3
|
59.9
|
1.0
|
|
HD2
|
A:PRO64
|
4.3
|
57.0
|
1.0
|
|
HH12
|
A:ARG266
|
4.3
|
47.6
|
1.0
|
|
CA
|
A:CYS52
|
4.4
|
59.6
|
1.0
|
|
HHB
|
A:HEM601
|
4.4
|
57.9
|
1.0
|
|
H
|
A:THR53
|
4.4
|
64.1
|
1.0
|
|
HHD
|
A:HEM601
|
4.4
|
56.6
|
1.0
|
|
HHA
|
A:HEM601
|
4.4
|
58.8
|
1.0
|
|
HHC
|
A:HEM601
|
4.4
|
57.5
|
1.0
|
|
HB3
|
A:CYS52
|
4.6
|
60.9
|
1.0
|
|
CG
|
A:HIS65
|
4.7
|
44.6
|
1.0
|
|
H
|
A:TRP54
|
4.7
|
59.0
|
1.0
|
|
ND1
|
A:HIS65
|
4.8
|
53.1
|
1.0
|
|
N
|
A:THR53
|
5.0
|
65.4
|
1.0
|
|
NH1
|
A:ARG266
|
5.0
|
50.0
|
1.0
|
|
Iron binding site 2 out
of 6 in 8s5i
Go back to
Iron Binding Sites List in 8s5i
Iron binding site 2 out
of 6 in the Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Fe601
b:85.4
occ:1.00
|
FE
|
B:HEM601
|
0.0
|
85.4
|
1.0
|
|
NC
|
B:HEM601
|
2.0
|
58.1
|
1.0
|
|
NA
|
B:HEM601
|
2.0
|
62.7
|
1.0
|
|
NB
|
B:HEM601
|
2.0
|
57.6
|
1.0
|
|
ND
|
B:HEM601
|
2.0
|
57.9
|
1.0
|
|
HG
|
B:CYS52
|
2.4
|
60.7
|
1.0
|
|
NE2
|
B:HIS65
|
2.7
|
49.5
|
1.0
|
|
C1D
|
B:HEM601
|
3.0
|
57.4
|
1.0
|
|
C4C
|
B:HEM601
|
3.0
|
51.8
|
1.0
|
|
C4A
|
B:HEM601
|
3.0
|
61.0
|
1.0
|
|
C1B
|
B:HEM601
|
3.0
|
56.1
|
1.0
|
|
C4D
|
B:HEM601
|
3.0
|
58.6
|
1.0
|
|
C1C
|
B:HEM601
|
3.0
|
54.3
|
1.0
|
|
C1A
|
B:HEM601
|
3.0
|
59.4
|
1.0
|
|
C4B
|
B:HEM601
|
3.1
|
58.5
|
1.0
|
|
SG
|
B:CYS52
|
3.2
|
63.7
|
1.0
|
|
HB2
|
B:CYS52
|
3.3
|
59.5
|
1.0
|
|
CHB
|
B:HEM601
|
3.4
|
58.2
|
1.0
|
|
CHD
|
B:HEM601
|
3.4
|
55.5
|
1.0
|
|
HD2
|
B:HIS65
|
3.4
|
50.8
|
1.0
|
|
CHA
|
B:HEM601
|
3.4
|
62.9
|
1.0
|
|
CHC
|
B:HEM601
|
3.4
|
56.6
|
1.0
|
|
CD2
|
B:HIS65
|
3.4
|
46.3
|
1.0
|
|
CB
|
B:CYS52
|
3.7
|
59.6
|
1.0
|
|
CE1
|
B:HIS65
|
3.8
|
53.8
|
1.0
|
|
HA
|
B:CYS52
|
3.8
|
59.8
|
1.0
|
|
HE1
|
B:HIS65
|
4.0
|
51.4
|
1.0
|
|
C2D
|
B:HEM601
|
4.2
|
55.4
|
1.0
|
|
C3D
|
B:HEM601
|
4.2
|
54.8
|
1.0
|
|
C3A
|
B:HEM601
|
4.2
|
58.6
|
1.0
|
|
HB2
|
B:TRP54
|
4.2
|
58.0
|
1.0
|
|
C2A
|
B:HEM601
|
4.2
|
55.2
|
1.0
|
|
C3C
|
B:HEM601
|
4.2
|
51.3
|
1.0
|
|
C2C
|
B:HEM601
|
4.2
|
52.4
|
1.0
|
|
C2B
|
B:HEM601
|
4.3
|
58.6
|
1.0
|
|
C3B
|
B:HEM601
|
4.3
|
59.9
|
1.0
|
|
HD2
|
B:PRO64
|
4.3
|
57.0
|
1.0
|
|
HH12
|
B:ARG266
|
4.3
|
47.6
|
1.0
|
|
CA
|
B:CYS52
|
4.3
|
59.6
|
1.0
|
|
HHB
|
B:HEM601
|
4.4
|
57.9
|
1.0
|
|
H
|
B:THR53
|
4.4
|
64.1
|
1.0
|
|
HHD
|
B:HEM601
|
4.4
|
56.6
|
1.0
|
|
HHA
|
B:HEM601
|
4.4
|
58.8
|
1.0
|
|
HHC
|
B:HEM601
|
4.4
|
57.5
|
1.0
|
|
HB3
|
B:CYS52
|
4.6
|
60.9
|
1.0
|
|
CG
|
B:HIS65
|
4.7
|
44.6
|
1.0
|
|
H
|
B:TRP54
|
4.7
|
59.0
|
1.0
|
|
ND1
|
B:HIS65
|
4.8
|
53.1
|
1.0
|
|
N
|
B:THR53
|
5.0
|
65.4
|
1.0
|
|
NH1
|
B:ARG266
|
5.0
|
50.0
|
1.0
|
|
Iron binding site 3 out
of 6 in 8s5i
Go back to
Iron Binding Sites List in 8s5i
Iron binding site 3 out
of 6 in the Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Fe601
b:69.7
occ:1.00
|
FE
|
C:HEM601
|
0.0
|
69.7
|
1.0
|
|
NB
|
C:HEM601
|
2.0
|
65.0
|
1.0
|
|
NA
|
C:HEM601
|
2.0
|
69.7
|
1.0
|
|
NC
|
C:HEM601
|
2.0
|
64.2
|
1.0
|
|
ND
|
C:HEM601
|
2.0
|
69.0
|
1.0
|
|
HG
|
C:CYS52
|
2.4
|
77.2
|
1.0
|
|
NE2
|
C:HIS65
|
2.8
|
61.7
|
1.0
|
|
C1A
|
C:HEM601
|
3.0
|
67.6
|
1.0
|
|
C4A
|
C:HEM601
|
3.0
|
67.5
|
1.0
|
|
C4D
|
C:HEM601
|
3.0
|
66.2
|
1.0
|
|
C1D
|
C:HEM601
|
3.0
|
65.8
|
1.0
|
|
C4C
|
C:HEM601
|
3.1
|
55.5
|
1.0
|
|
C4B
|
C:HEM601
|
3.1
|
65.4
|
1.0
|
|
C1B
|
C:HEM601
|
3.1
|
63.0
|
1.0
|
|
C1C
|
C:HEM601
|
3.1
|
62.6
|
1.0
|
|
HD2
|
C:HIS65
|
3.2
|
58.5
|
1.0
|
|
CD2
|
C:HIS65
|
3.4
|
58.5
|
1.0
|
|
CHA
|
C:HEM601
|
3.4
|
68.0
|
1.0
|
|
CHB
|
C:HEM601
|
3.4
|
62.3
|
1.0
|
|
CHC
|
C:HEM601
|
3.4
|
63.7
|
1.0
|
|
CHD
|
C:HEM601
|
3.4
|
57.2
|
1.0
|
|
SG
|
C:CYS52
|
3.5
|
77.2
|
1.0
|
|
HD2
|
C:PRO64
|
3.6
|
60.9
|
1.0
|
|
HA
|
C:CYS52
|
3.8
|
71.2
|
1.0
|
|
CE1
|
C:HIS65
|
4.0
|
57.0
|
1.0
|
|
HB2
|
C:CYS52
|
4.0
|
70.0
|
1.0
|
|
HB2
|
C:TRP54
|
4.1
|
64.7
|
1.0
|
|
H
|
C:THR53
|
4.1
|
75.4
|
1.0
|
|
C2A
|
C:HEM601
|
4.2
|
64.4
|
1.0
|
|
CB
|
C:CYS52
|
4.2
|
70.0
|
1.0
|
|
C3A
|
C:HEM601
|
4.2
|
65.9
|
1.0
|
|
C3D
|
C:HEM601
|
4.2
|
63.7
|
1.0
|
|
C2D
|
C:HEM601
|
4.3
|
64.9
|
1.0
|
|
C3C
|
C:HEM601
|
4.3
|
57.2
|
1.0
|
|
C3B
|
C:HEM601
|
4.3
|
67.9
|
1.0
|
|
C2C
|
C:HEM601
|
4.3
|
61.7
|
1.0
|
|
C2B
|
C:HEM601
|
4.3
|
66.3
|
1.0
|
|
HE1
|
C:HIS65
|
4.3
|
57.0
|
1.0
|
|
HH12
|
C:ARG266
|
4.3
|
49.9
|
1.0
|
|
HHA
|
C:HEM601
|
4.4
|
68.0
|
1.0
|
|
HHB
|
C:HEM601
|
4.4
|
62.3
|
1.0
|
|
HHC
|
C:HEM601
|
4.4
|
63.7
|
1.0
|
|
HHD
|
C:HEM601
|
4.4
|
57.2
|
1.0
|
|
CD
|
C:PRO64
|
4.4
|
60.9
|
1.0
|
|
HD3
|
C:PRO64
|
4.5
|
60.9
|
1.0
|
|
H
|
C:TRP54
|
4.5
|
67.3
|
1.0
|
|
CA
|
C:CYS52
|
4.5
|
71.2
|
1.0
|
|
OG
|
C:SER63
|
4.6
|
76.8
|
1.0
|
|
CG
|
C:HIS65
|
4.7
|
55.1
|
1.0
|
|
HG2
|
C:PRO64
|
4.7
|
59.1
|
1.0
|
|
HG
|
C:SER63
|
4.8
|
76.8
|
1.0
|
|
N
|
C:THR53
|
4.8
|
75.4
|
1.0
|
|
CB
|
C:TRP54
|
4.9
|
64.7
|
1.0
|
|
ND1
|
C:HIS65
|
4.9
|
54.5
|
1.0
|
|
HB3
|
C:TRP54
|
4.9
|
64.7
|
1.0
|
|
NH1
|
C:ARG266
|
5.0
|
49.9
|
1.0
|
|
Iron binding site 4 out
of 6 in 8s5i
Go back to
Iron Binding Sites List in 8s5i
Iron binding site 4 out
of 6 in the Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Fe601
b:69.7
occ:1.00
|
FE
|
D:HEM601
|
0.0
|
69.7
|
1.0
|
|
NC
|
D:HEM601
|
2.0
|
64.2
|
1.0
|
|
NA
|
D:HEM601
|
2.0
|
69.7
|
1.0
|
|
ND
|
D:HEM601
|
2.0
|
69.0
|
1.0
|
|
NB
|
D:HEM601
|
2.0
|
65.0
|
1.0
|
|
HG
|
D:CYS52
|
2.4
|
77.2
|
1.0
|
|
NE2
|
D:HIS65
|
2.8
|
61.7
|
1.0
|
|
C4D
|
D:HEM601
|
3.0
|
66.2
|
1.0
|
|
C1D
|
D:HEM601
|
3.0
|
65.8
|
1.0
|
|
C1A
|
D:HEM601
|
3.0
|
67.6
|
1.0
|
|
C4C
|
D:HEM601
|
3.0
|
55.5
|
1.0
|
|
C1C
|
D:HEM601
|
3.0
|
62.6
|
1.0
|
|
C4A
|
D:HEM601
|
3.0
|
67.5
|
1.0
|
|
C1B
|
D:HEM601
|
3.0
|
63.0
|
1.0
|
|
C4B
|
D:HEM601
|
3.1
|
65.4
|
1.0
|
|
SG
|
D:CYS52
|
3.2
|
77.2
|
1.0
|
|
HD2
|
D:HIS65
|
3.2
|
58.5
|
1.0
|
|
CD2
|
D:HIS65
|
3.4
|
58.5
|
1.0
|
|
CHA
|
D:HEM601
|
3.4
|
68.0
|
1.0
|
|
CHC
|
D:HEM601
|
3.4
|
63.7
|
1.0
|
|
CHD
|
D:HEM601
|
3.4
|
57.2
|
1.0
|
|
CHB
|
D:HEM601
|
3.4
|
62.3
|
1.0
|
|
HB2
|
D:CYS52
|
3.5
|
70.0
|
1.0
|
|
HD2
|
D:PRO64
|
3.6
|
60.9
|
1.0
|
|
CB
|
D:CYS52
|
3.9
|
70.0
|
1.0
|
|
CE1
|
D:HIS65
|
3.9
|
57.0
|
1.0
|
|
HH12
|
D:ARG266
|
4.0
|
49.9
|
1.0
|
|
HA
|
D:CYS52
|
4.0
|
71.2
|
1.0
|
|
HB2
|
D:TRP54
|
4.2
|
64.7
|
1.0
|
|
C3D
|
D:HEM601
|
4.2
|
63.7
|
1.0
|
|
C2D
|
D:HEM601
|
4.2
|
64.9
|
1.0
|
|
C2A
|
D:HEM601
|
4.2
|
64.4
|
1.0
|
|
C3A
|
D:HEM601
|
4.2
|
65.9
|
1.0
|
|
C3C
|
D:HEM601
|
4.3
|
57.2
|
1.0
|
|
C2B
|
D:HEM601
|
4.3
|
66.3
|
1.0
|
|
C2C
|
D:HEM601
|
4.3
|
61.7
|
1.0
|
|
HE1
|
D:HIS65
|
4.3
|
57.0
|
1.0
|
|
C3B
|
D:HEM601
|
4.3
|
67.9
|
1.0
|
|
HHC
|
D:HEM601
|
4.3
|
63.7
|
1.0
|
|
HHA
|
D:HEM601
|
4.4
|
68.0
|
1.0
|
|
HHD
|
D:HEM601
|
4.4
|
57.2
|
1.0
|
|
HHB
|
D:HEM601
|
4.4
|
62.3
|
1.0
|
|
CD
|
D:PRO64
|
4.4
|
60.9
|
1.0
|
|
HD3
|
D:PRO64
|
4.4
|
60.9
|
1.0
|
|
H
|
D:THR53
|
4.5
|
75.4
|
1.0
|
|
CA
|
D:CYS52
|
4.5
|
71.2
|
1.0
|
|
HG2
|
D:PRO64
|
4.6
|
59.1
|
1.0
|
|
CG
|
D:HIS65
|
4.6
|
55.1
|
1.0
|
|
H
|
D:TRP54
|
4.7
|
67.3
|
1.0
|
|
HB3
|
D:CYS52
|
4.7
|
70.0
|
1.0
|
|
NH1
|
D:ARG266
|
4.7
|
49.9
|
1.0
|
|
HH11
|
D:ARG266
|
4.8
|
49.9
|
1.0
|
|
ND1
|
D:HIS65
|
4.9
|
54.5
|
1.0
|
|
Iron binding site 5 out
of 6 in 8s5i
Go back to
Iron Binding Sites List in 8s5i
Iron binding site 5 out
of 6 in the Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 5 of Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Fe601
b:69.7
occ:1.00
|
FE
|
E:HEM601
|
0.0
|
69.7
|
1.0
|
|
NC
|
E:HEM601
|
2.0
|
64.2
|
1.0
|
|
NA
|
E:HEM601
|
2.0
|
69.7
|
1.0
|
|
ND
|
E:HEM601
|
2.0
|
69.0
|
1.0
|
|
NB
|
E:HEM601
|
2.0
|
65.0
|
1.0
|
|
HG
|
E:CYS52
|
2.4
|
77.2
|
1.0
|
|
NE2
|
E:HIS65
|
2.8
|
61.7
|
1.0
|
|
C1A
|
E:HEM601
|
3.0
|
67.6
|
1.0
|
|
C4D
|
E:HEM601
|
3.0
|
66.2
|
1.0
|
|
C1D
|
E:HEM601
|
3.0
|
65.8
|
1.0
|
|
C4A
|
E:HEM601
|
3.0
|
67.5
|
1.0
|
|
C1C
|
E:HEM601
|
3.0
|
62.6
|
1.0
|
|
C4C
|
E:HEM601
|
3.0
|
55.5
|
1.0
|
|
C1B
|
E:HEM601
|
3.0
|
63.0
|
1.0
|
|
C4B
|
E:HEM601
|
3.1
|
65.4
|
1.0
|
|
SG
|
E:CYS52
|
3.2
|
77.2
|
1.0
|
|
HD2
|
E:HIS65
|
3.3
|
58.5
|
1.0
|
|
CHA
|
E:HEM601
|
3.4
|
68.0
|
1.0
|
|
CHC
|
E:HEM601
|
3.4
|
63.7
|
1.0
|
|
CD2
|
E:HIS65
|
3.4
|
58.5
|
1.0
|
|
CHB
|
E:HEM601
|
3.4
|
62.3
|
1.0
|
|
CHD
|
E:HEM601
|
3.4
|
57.2
|
1.0
|
|
HD2
|
E:PRO64
|
3.6
|
60.9
|
1.0
|
|
HB2
|
E:CYS52
|
3.8
|
70.0
|
1.0
|
|
CE1
|
E:HIS65
|
3.9
|
57.0
|
1.0
|
|
HH12
|
E:ARG266
|
4.0
|
49.9
|
1.0
|
|
CB
|
E:CYS52
|
4.1
|
70.0
|
1.0
|
|
HA
|
E:CYS52
|
4.2
|
71.2
|
1.0
|
|
C3D
|
E:HEM601
|
4.2
|
63.7
|
1.0
|
|
HB2
|
E:TRP54
|
4.2
|
64.7
|
1.0
|
|
C2D
|
E:HEM601
|
4.2
|
64.9
|
1.0
|
|
C2A
|
E:HEM601
|
4.2
|
64.4
|
1.0
|
|
C3A
|
E:HEM601
|
4.2
|
65.9
|
1.0
|
|
HE1
|
E:HIS65
|
4.2
|
57.0
|
1.0
|
|
C2B
|
E:HEM601
|
4.3
|
66.3
|
1.0
|
|
C3C
|
E:HEM601
|
4.3
|
57.2
|
1.0
|
|
C2C
|
E:HEM601
|
4.3
|
61.7
|
1.0
|
|
C3B
|
E:HEM601
|
4.3
|
67.9
|
1.0
|
|
HHC
|
E:HEM601
|
4.3
|
63.7
|
1.0
|
|
HHA
|
E:HEM601
|
4.4
|
68.0
|
1.0
|
|
HHB
|
E:HEM601
|
4.4
|
62.3
|
1.0
|
|
CD
|
E:PRO64
|
4.4
|
60.9
|
1.0
|
|
HHD
|
E:HEM601
|
4.4
|
57.2
|
1.0
|
|
HD3
|
E:PRO64
|
4.4
|
60.9
|
1.0
|
|
H
|
E:THR53
|
4.5
|
75.4
|
1.0
|
|
HG2
|
E:PRO64
|
4.5
|
59.1
|
1.0
|
|
CG
|
E:HIS65
|
4.7
|
55.1
|
1.0
|
|
CA
|
E:CYS52
|
4.7
|
71.2
|
1.0
|
|
NH1
|
E:ARG266
|
4.7
|
49.9
|
1.0
|
|
HH11
|
E:ARG266
|
4.8
|
49.9
|
1.0
|
|
H
|
E:TRP54
|
4.9
|
67.3
|
1.0
|
|
ND1
|
E:HIS65
|
4.9
|
54.5
|
1.0
|
|
HB3
|
E:CYS52
|
4.9
|
70.0
|
1.0
|
|
OG
|
E:SER63
|
5.0
|
76.8
|
1.0
|
|
Iron binding site 6 out
of 6 in 8s5i
Go back to
Iron Binding Sites List in 8s5i
Iron binding site 6 out
of 6 in the Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction
 Mono view
 Stereo pair view
|
|
A full contact list of Iron with other atoms in the Fe binding
site number 6 of Full-Length Human Cystathionine Beta-Synthase with C-Terminal 6XHIS- Tag, Basal State, Single Particle Reconstruction within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:Fe601
b:69.7
occ:1.00
|
FE
|
F:HEM601
|
0.0
|
69.7
|
1.0
|
|
NC
|
F:HEM601
|
2.0
|
64.2
|
1.0
|
|
NA
|
F:HEM601
|
2.0
|
69.7
|
1.0
|
|
ND
|
F:HEM601
|
2.0
|
69.0
|
1.0
|
|
NB
|
F:HEM601
|
2.0
|
65.0
|
1.0
|
|
HG
|
F:CYS52
|
2.4
|
77.2
|
1.0
|
|
C4A
|
F:HEM601
|
3.0
|
67.5
|
1.0
|
|
C1A
|
F:HEM601
|
3.0
|
67.6
|
1.0
|
|
NE2
|
F:HIS65
|
3.0
|
61.7
|
1.0
|
|
C1B
|
F:HEM601
|
3.0
|
63.0
|
1.0
|
|
C4D
|
F:HEM601
|
3.1
|
66.2
|
1.0
|
|
C4C
|
F:HEM601
|
3.1
|
55.5
|
1.0
|
|
C1D
|
F:HEM601
|
3.1
|
65.8
|
1.0
|
|
C1C
|
F:HEM601
|
3.1
|
62.6
|
1.0
|
|
C4B
|
F:HEM601
|
3.1
|
65.4
|
1.0
|
|
HD2
|
F:HIS65
|
3.3
|
58.5
|
1.0
|
|
CHB
|
F:HEM601
|
3.4
|
62.3
|
1.0
|
|
CHA
|
F:HEM601
|
3.4
|
68.0
|
1.0
|
|
CHC
|
F:HEM601
|
3.4
|
63.7
|
1.0
|
|
CHD
|
F:HEM601
|
3.4
|
57.2
|
1.0
|
|
CD2
|
F:HIS65
|
3.5
|
58.5
|
1.0
|
|
SG
|
F:CYS52
|
3.5
|
77.2
|
1.0
|
|
HD2
|
F:PRO64
|
3.6
|
60.9
|
1.0
|
|
HA
|
F:CYS52
|
3.8
|
71.2
|
1.0
|
|
HB2
|
F:CYS52
|
4.1
|
70.0
|
1.0
|
|
H
|
F:THR53
|
4.2
|
75.4
|
1.0
|
|
CE1
|
F:HIS65
|
4.2
|
57.0
|
1.0
|
|
C3A
|
F:HEM601
|
4.2
|
65.9
|
1.0
|
|
C2A
|
F:HEM601
|
4.2
|
64.4
|
1.0
|
|
C2D
|
F:HEM601
|
4.3
|
64.9
|
1.0
|
|
C3D
|
F:HEM601
|
4.3
|
63.7
|
1.0
|
|
HB2
|
F:TRP54
|
4.3
|
64.7
|
1.0
|
|
C2B
|
F:HEM601
|
4.3
|
66.3
|
1.0
|
|
C3C
|
F:HEM601
|
4.3
|
57.2
|
1.0
|
|
C2C
|
F:HEM601
|
4.3
|
61.7
|
1.0
|
|
C3B
|
F:HEM601
|
4.3
|
67.9
|
1.0
|
|
CB
|
F:CYS52
|
4.3
|
70.0
|
1.0
|
|
OG
|
F:SER63
|
4.3
|
76.8
|
1.0
|
|
HH12
|
F:ARG266
|
4.3
|
49.9
|
1.0
|
|
HHB
|
F:HEM601
|
4.4
|
62.3
|
1.0
|
|
HHA
|
F:HEM601
|
4.4
|
68.0
|
1.0
|
|
HHC
|
F:HEM601
|
4.4
|
63.7
|
1.0
|
|
HHD
|
F:HEM601
|
4.4
|
57.2
|
1.0
|
|
CD
|
F:PRO64
|
4.4
|
60.9
|
1.0
|
|
HD3
|
F:PRO64
|
4.5
|
60.9
|
1.0
|
|
HG
|
F:SER63
|
4.5
|
76.8
|
1.0
|
|
HE1
|
F:HIS65
|
4.5
|
57.0
|
1.0
|
|
CA
|
F:CYS52
|
4.5
|
71.2
|
1.0
|
|
HA
|
F:SER63
|
4.7
|
73.7
|
1.0
|
|
CG
|
F:HIS65
|
4.8
|
55.1
|
1.0
|
|
H
|
F:TRP54
|
4.8
|
67.3
|
1.0
|
|
N
|
F:THR53
|
4.9
|
75.4
|
1.0
|
|
HG2
|
F:PRO64
|
5.0
|
59.1
|
1.0
|
|
Reference:
T.J.Mccorvie,
D.Adamoski,
R.A.C.Machado,
J.Tang,
H.J.Bailey,
D.S.M.Ferreira,
C.Strain-Damerell,
A.Basle,
A.L.B.Ambrosio,
S.M.G.Dias,
W.W.Yue.
Architecture and Regulation of Filamentous Human Cystathionine Beta-Synthase. Nat Commun V. 15 2931 2024.
ISSN: ESSN 2041-1723
PubMed: 38575566
DOI: 10.1038/S41467-024-46864-X
Page generated: Thu Aug 7 23:24:59 2025
|
