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Iron in PDB 9cvs: Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride
Enzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride
All present enzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride:
1.14.13.39;
1.14.13.39;
Protein crystallography data
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride, PDB code: 9cvs
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 39.28 / 1.80 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 52.353, 118.843, 165.112, 90, 90.12, 90 |
| R / Rfree (%) | 18 / 22.2 |
Other elements in 9cvs:
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
Iron Binding Sites:
The binding sites of Iron atom in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride
(pdb code 9cvs). This binding sites where shown within
5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride, PDB code: 9cvs:
Jump to Iron binding site number: 1; 2; 3; 4;
In total 4 binding sites of Iron where determined in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride, PDB code: 9cvs:
Jump to Iron binding site number: 1; 2; 3; 4;
Iron binding site 1 out of 4 in 9cvs
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Iron Binding Sites List in 9cvs
Iron binding site 1 out
of 4 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 1 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride within 5.0Å range:
|
Iron binding site 2 out of 4 in 9cvs
Go back to
Iron Binding Sites List in 9cvs
Iron binding site 2 out
of 4 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 2 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride within 5.0Å range:
|
Iron binding site 3 out of 4 in 9cvs
Go back to
Iron Binding Sites List in 9cvs
Iron binding site 3 out
of 4 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 3 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride within 5.0Å range:
|
Iron binding site 4 out of 4 in 9cvs
Go back to
Iron Binding Sites List in 9cvs
Iron binding site 4 out
of 4 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iron with other atoms in the Fe binding
site number 4 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain Bound with 4-Methyl-6-(3-((Methylamino)Methyl)Phenyl) Pyridin-2-Amine Dihydrochloride within 5.0Å range:
|
Reference:
D.Vasu,
H.T.Do,
H.Li,
C.D.Hardy,
T.L.Poulos,
R.B.Silverman.
Truncated Pyridinylbenzylamines: Potent, Selective, and Highly Membrane Permeable Inhibitors of Human Neuronal Nitric Oxide Synthase. Bioorg.Med.Chem. V. 124 18193 2025.
ISSN: ESSN 1464-3391
PubMed: 40252563
DOI: 10.1016/J.BMC.2025.118193
Page generated: Fri Aug 8 03:39:42 2025
ISSN: ESSN 1464-3391
PubMed: 40252563
DOI: 10.1016/J.BMC.2025.118193
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