Iron in PDB 9fno: Cryo-Em Structure of Human CD163 SRCR1-9 in Complex with Haptoglobin- Hemoglobin

The structure of Cryo-Em Structure of Human CD163 SRCR1-9 in Complex with Haptoglobin- Hemoglobin also contains other interesting chemical elements:

Calcium

(Ca)

4 atoms

The binding sites of Iron atom in the Cryo-Em Structure of Human CD163 SRCR1-9 in Complex with Haptoglobin- Hemoglobin (pdb code 9fno). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Cryo-Em Structure of Human CD163 SRCR1-9 in Complex with Haptoglobin- Hemoglobin, PDB code: 9fno:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in the Cryo-Em Structure of Human CD163 SRCR1-9 in Complex with Haptoglobin- Hemoglobin


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Cryo-Em Structure of Human CD163 SRCR1-9 in Complex with Haptoglobin- Hemoglobin within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe201 b:222.2 occ:1.00 FE A:HEM201 0.0 222.2 1.0 ND A:HEM201 2.0 222.2 1.0 NB A:HEM201 2.0 222.2 1.0 NC A:HEM201 2.0 222.2 1.0 NA A:HEM201 2.0 222.2 1.0 NE2 A:HIS87 2.7 214.2 1.0 C1C A:HEM201 3.0 222.2 1.0 C4C A:HEM201 3.0 222.2 1.0 CD2 A:HIS87 3.0 214.2 1.0 C4B A:HEM201 3.0 222.2 1.0 C4D A:HEM201 3.0 222.2 1.0 C1A A:HEM201 3.0 222.2 1.0 C1D A:HEM201 3.1 222.2 1.0 C1B A:HEM201 3.1 222.2 1.0 C4A A:HEM201 3.1 222.2 1.0 CHC A:HEM201 3.4 222.2 1.0 CHA A:HEM201 3.4 222.2 1.0 CHD A:HEM201 3.4 222.2 1.0 CHB A:HEM201 3.4 222.2 1.0 CE1 A:HIS87 4.0 214.2 1.0 C2C A:HEM201 4.2 222.2 1.0 C3C A:HEM201 4.2 222.2 1.0 C3D A:HEM201 4.3 222.2 1.0 C2A A:HEM201 4.3 222.2 1.0 C2D A:HEM201 4.3 222.2 1.0 C3B A:HEM201 4.3 222.2 1.0 C3A A:HEM201 4.3 222.2 1.0 C2B A:HEM201 4.3 222.2 1.0 NE2 A:HIS58 4.3 225.9 1.0 CG A:HIS87 4.4 214.2 1.0 CG1 A:VAL62 4.6 201.5 1.0 CE1 A:HIS58 4.6 225.9 1.0 ND1 A:HIS87 4.8 214.2 1.0

Iron binding site 2 out of 2 in the Cryo-Em Structure of Human CD163 SRCR1-9 in Complex with Haptoglobin- Hemoglobin


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Cryo-Em Structure of Human CD163 SRCR1-9 in Complex with Haptoglobin- Hemoglobin within 5.0Å range: probe atom residue distance (Å) B Occ B:Fe201 b:278.9 occ:1.00 FE B:HEM201 0.0 278.9 1.0 NB B:HEM201 2.0 278.9 1.0 ND B:HEM201 2.1 278.9 1.0 NC B:HEM201 2.1 278.9 1.0 NA B:HEM201 2.1 278.9 1.0 NE2 B:HIS92 2.8 289.2 1.0 C4C B:HEM201 3.0 278.9 1.0 C1C B:HEM201 3.0 278.9 1.0 CE1 B:HIS92 3.0 289.2 1.0 C1D B:HEM201 3.0 278.9 1.0 C1B B:HEM201 3.1 278.9 1.0 C4D B:HEM201 3.1 278.9 1.0 C4B B:HEM201 3.1 278.9 1.0 C4A B:HEM201 3.1 278.9 1.0 C1A B:HEM201 3.1 278.9 1.0 CHD B:HEM201 3.4 278.9 1.0 CHC B:HEM201 3.4 278.9 1.0 CHB B:HEM201 3.4 278.9 1.0 CHA B:HEM201 3.5 278.9 1.0 CD2 B:HIS92 3.5 289.2 1.0 ND1 B:HIS92 3.8 289.2 1.0 CG B:HIS92 4.1 289.2 1.0 C3C B:HEM201 4.1 278.9 1.0 C2C B:HEM201 4.1 278.9 1.0 C2D B:HEM201 4.2 278.9 1.0 C3D B:HEM201 4.2 278.9 1.0 C2B B:HEM201 4.3 278.9 1.0 C3A B:HEM201 4.3 278.9 1.0 C3B B:HEM201 4.3 278.9 1.0 C2A B:HEM201 4.3 278.9 1.0 CE1 B:HIS63 4.3 267.8 1.0 CG2 B:VAL67 4.5 269.0 1.0 NE2 B:HIS63 4.8 267.8 1.0

A.Etzerodt, J.H.Mikkelsen, M.Torvund-Jensen, D.Hennig, T.Boesen, J.H.Graversen, S.K.Moestrup, J.M.Kollman, C.B.F.Andersen. The Cryo-Em Structure of Human CD163 Bound to Haptoglobin-Hemoglobin Reveals Molecular Mechanisms of Hemoglobin Scavenging. Nat Commun V. 15 10871 2024.
ISSN: ESSN 2041-1723
PubMed: 39738064
DOI: 10.1038/S41467-024-55171-4