Iron in PDB 9ne6: Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State

All present enzymatic activity of Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State:
2.7.7.7;

The binding sites of Iron atom in the Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State (pdb code 9ne6). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 4 binding sites of Iron where determined in the Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State, PDB code: 9ne6:
Jump to Iron binding site number: 1; 2; 3; 4;

Iron binding site 1 out of 4 in the Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1301 b:90.3 occ:1.00 FE1 A:SF41301 0.0 90.3 1.0 SG A:CYS651 2.3 62.2 1.0 S4 A:SF41301 2.3 80.8 1.0 S2 A:SF41301 2.3 47.3 1.0 S3 A:SF41301 2.3 68.2 1.0 FE2 A:SF41301 2.7 63.1 1.0 FE3 A:SF41301 2.7 66.5 1.0 FE4 A:SF41301 2.7 68.6 1.0 CB A:CYS651 3.6 65.6 1.0 O A:CYS651 3.8 76.8 1.0 S1 A:SF41301 3.9 63.5 1.0 CA A:CYS651 4.0 66.4 1.0 NE2 A:GLN664 4.1 62.7 1.0 CG1 A:VAL646 4.1 44.7 1.0 C A:CYS651 4.3 70.2 1.0 SG A:CYS654 4.5 73.7 1.0 CG A:GLN664 4.6 46.2 1.0 SG A:CYS663 4.7 68.1 1.0 CD A:GLN664 4.8 59.3 1.0 SG A:CYS747 4.8 41.1 1.0 CB A:CYS747 4.8 32.4 1.0 CG2 A:VAL646 4.9 58.0 1.0

Iron binding site 2 out of 4 in the Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1301 b:63.1 occ:1.00 FE2 A:SF41301 0.0 63.1 1.0 SG A:CYS654 2.3 73.7 1.0 S1 A:SF41301 2.3 63.5 1.0 S3 A:SF41301 2.3 68.2 1.0 S4 A:SF41301 2.3 80.8 1.0 FE1 A:SF41301 2.7 90.3 1.0 FE3 A:SF41301 2.7 66.5 1.0 FE4 A:SF41301 2.7 68.6 1.0 O A:CYS651 3.8 76.8 1.0 CB A:CYS654 3.8 69.0 1.0 S2 A:SF41301 3.9 47.3 1.0 CB A:PHE656 4.4 68.3 1.0 SG A:CYS651 4.5 62.2 1.0 C A:PHE656 4.6 78.9 1.0 C A:CYS651 4.8 70.2 1.0 O A:PHE656 4.8 82.2 1.0 SG A:CYS747 4.8 41.1 1.0 N A:ASN657 4.8 77.6 1.0 SG A:CYS663 4.8 68.1 1.0 N A:PHE656 4.9 69.3 1.0 CA A:PHE656 4.9 72.8 1.0 CA A:CYS651 4.9 66.4 1.0

Iron binding site 3 out of 4 in the Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 3 of Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1301 b:66.5 occ:1.00 FE3 A:SF41301 0.0 66.5 1.0 SG A:CYS663 2.3 68.1 1.0 S4 A:SF41301 2.3 80.8 1.0 S1 A:SF41301 2.3 63.5 1.0 S2 A:SF41301 2.3 47.3 1.0 FE4 A:SF41301 2.7 68.6 1.0 FE1 A:SF41301 2.7 90.3 1.0 FE2 A:SF41301 2.7 63.1 1.0 CB A:CYS663 3.2 52.6 1.0 NE2 A:GLN664 3.7 62.7 1.0 S3 A:SF41301 3.9 68.2 1.0 O A:PHE656 4.0 82.2 1.0 CD A:GLN664 4.3 59.3 1.0 C A:CYS663 4.4 46.8 1.0 CA A:CYS663 4.4 50.9 1.0 N A:GLN664 4.4 53.9 1.0 C A:PHE656 4.5 78.9 1.0 SG A:CYS651 4.6 62.2 1.0 CG A:GLN664 4.7 46.2 1.0 CB A:PHE656 4.7 68.3 1.0 SG A:CYS747 4.7 41.1 1.0 SG A:CYS654 4.8 73.7 1.0 O A:CYS663 4.8 38.5 1.0 OE1 A:GLN664 4.9 62.2 1.0

Iron binding site 4 out of 4 in the Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 4 of Human Polymerase Epsilon Bound to Pcna and Dna with An in-Situ- Generated Mismatch in the Mismatch-Editing State within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1301 b:68.6 occ:1.00 FE4 A:SF41301 0.0 68.6 1.0 SG A:CYS747 2.3 41.1 1.0 S3 A:SF41301 2.3 68.2 1.0 S1 A:SF41301 2.3 63.5 1.0 S2 A:SF41301 2.3 47.3 1.0 FE3 A:SF41301 2.7 66.5 1.0 FE1 A:SF41301 2.7 90.3 1.0 FE2 A:SF41301 2.7 63.1 1.0 CB A:CYS747 3.1 32.4 1.0 S4 A:SF41301 3.9 80.8 1.0 CA A:CYS747 3.9 29.6 1.0 CD1 A:LEU145 4.3 48.4 1.0 CG A:ARG749 4.6 45.5 1.0 C A:CYS747 4.6 31.7 1.0 SG A:CYS663 4.8 68.1 1.0 SG A:CYS654 4.9 73.7 1.0 N A:GLN748 4.9 35.2 1.0 SG A:CYS651 5.0 62.2 1.0 CB A:CYS663 5.0 52.6 1.0

F.Wang, Q.He, M.E.O'donnell, H.Li. The Proofreading Mechanism of the Human Leading-Strand Dna Polymerase Epsilon Holoenzyme. Proc.Natl.Acad.Sci.Usa V. 122 32122 2025.
ISSN: ESSN 1091-6490
PubMed: 40440070
DOI: 10.1073/PNAS.2507232122