Iron in PDB 1ebv: Ovine Pghs-1 Complexed with Salicyl Hydroxamic Acid

All present enzymatic activity of Ovine Pghs-1 Complexed with Salicyl Hydroxamic Acid:
1.14.99.1;

The structure of Ovine Pghs-1 Complexed with Salicyl Hydroxamic Acid, PDB code: 1ebv was solved by P.J.Loll, C.T.Sharkey, S.J.O'connor, D.J.Fitzgerald, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.50 / 3.20
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	98.870, 207.460, 221.980, 90.00, 90.00, 90.00
R / Rfree (%)	21.8 / 24.8

The binding sites of Iron atom in the Ovine Pghs-1 Complexed with Salicyl Hydroxamic Acid (pdb code 1ebv). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Ovine Pghs-1 Complexed with Salicyl Hydroxamic Acid, PDB code: 1ebv:

Iron binding site 1 out of 1 in the Ovine Pghs-1 Complexed with Salicyl Hydroxamic Acid


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Ovine Pghs-1 Complexed with Salicyl Hydroxamic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe601 b:18.9 occ:1.00 FE A:HEM601 0.0 18.9 1.0 ND A:HEM601 1.9 20.1 1.0 NC A:HEM601 2.0 19.5 1.0 NA A:HEM601 2.0 21.6 1.0 NB A:HEM601 2.0 18.8 1.0 NE2 A:HIS388 2.0 17.5 1.0 CD2 A:HIS388 3.0 15.3 1.0 C4D A:HEM601 3.0 20.2 1.0 C1D A:HEM601 3.0 19.7 1.0 C4A A:HEM601 3.0 22.0 1.0 C1C A:HEM601 3.0 19.2 1.0 C1B A:HEM601 3.0 18.7 1.0 C4C A:HEM601 3.0 19.6 1.0 CE1 A:HIS388 3.0 16.1 1.0 C1A A:HEM601 3.1 23.0 1.0 C4B A:HEM601 3.1 17.5 1.0 CHB A:HEM601 3.4 20.2 1.0 CHA A:HEM601 3.4 21.5 1.0 CHD A:HEM601 3.4 19.4 1.0 CHC A:HEM601 3.4 18.0 1.0 CG A:HIS388 4.1 13.4 1.0 ND1 A:HIS388 4.1 14.4 1.0 C3D A:HEM601 4.2 19.6 1.0 C3A A:HEM601 4.3 23.3 1.0 C2D A:HEM601 4.3 19.3 1.0 C2C A:HEM601 4.3 19.3 1.0 C2B A:HEM601 4.3 17.6 1.0 C3C A:HEM601 4.3 19.3 1.0 C2A A:HEM601 4.3 25.0 1.0 C3B A:HEM601 4.4 16.8 1.0 NE2 A:HIS207 4.5 9.1 1.0 CE1 A:HIS207 4.6 8.1 1.0 OE1 A:GLN203 4.7 11.4 1.0 CD A:GLN203 5.0 10.7 1.0

P.J.Loll, C.T.Sharkey, S.J.O'connor, C.M.Dooley, E.O'brien, M.Devocelle, K.B.Nolan, B.S.Selinsky, D.J.Fitzgerald. O-Acetylsalicylhydroxamic Acid, A Novel Acetylating Inhibitor of Prostaglandin H2 Synthase: Structural and Functional Characterization of Enzyme-Inhibitor Interactions. Mol.Pharmacol. V. 60 1407 2001.
ISSN: ISSN 0026-895X
PubMed: 11723249