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Iron in PDB 1fah: Structure of Cytochrome P450

Enzymatic activity of Structure of Cytochrome P450

All present enzymatic activity of Structure of Cytochrome P450:
1.14.14.1;

Protein crystallography data

The structure of Structure of Cytochrome P450, PDB code: 1fah was solved by H.Y.Li, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 2.30
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 59.500, 154.000, 62.400, 90.00, 95.00, 90.00
R / Rfree (%) 17.2 / n/a

Iron Binding Sites:

The binding sites of Iron atom in the Structure of Cytochrome P450 (pdb code 1fah). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total 2 binding sites of Iron where determined in the Structure of Cytochrome P450, PDB code: 1fah:
Jump to Iron binding site number: 1; 2;

Iron binding site 1 out of 2 in 1fah

Go back to Iron Binding Sites List in 1fah
Iron binding site 1 out of 2 in the Structure of Cytochrome P450


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Structure of Cytochrome P450 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Fe472

b:10.1
occ:1.00
FE A:HEM472 0.0 10.1 1.0
O A:HOH473 1.9 5.6 1.0
NA A:HEM472 2.0 7.6 1.0
NC A:HEM472 2.0 5.6 1.0
NB A:HEM472 2.0 12.2 1.0
ND A:HEM472 2.0 16.9 1.0
SG A:CYS400 2.0 5.3 1.0
C4C A:HEM472 3.0 8.4 1.0
C1C A:HEM472 3.0 4.0 1.0
C4A A:HEM472 3.0 11.8 1.0
C1A A:HEM472 3.0 14.4 1.0
C4B A:HEM472 3.1 13.1 1.0
C1B A:HEM472 3.1 6.2 1.0
C1D A:HEM472 3.1 14.9 1.0
C4D A:HEM472 3.1 14.2 1.0
CB A:CYS400 3.2 12.0 1.0
CHB A:HEM472 3.4 10.7 1.0
CHC A:HEM472 3.4 10.6 1.0
CHD A:HEM472 3.4 11.5 1.0
CHA A:HEM472 3.5 14.8 1.0
CA A:CYS400 4.0 9.2 1.0
C3C A:HEM472 4.3 7.7 1.0
C2C A:HEM472 4.3 3.7 1.0
C2A A:HEM472 4.3 9.7 1.0
C3A A:HEM472 4.3 4.6 1.0
C3B A:HEM472 4.3 11.8 1.0
C2B A:HEM472 4.3 9.4 1.0
C2D A:HEM472 4.3 10.3 1.0
C3D A:HEM472 4.4 9.2 1.0
O A:ALA264 4.4 14.0 1.0
O A:HOH619 4.6 34.4 1.0
C A:CYS400 4.8 10.7 1.0
N A:GLY402 4.9 4.1 1.0

Iron binding site 2 out of 2 in 1fah

Go back to Iron Binding Sites List in 1fah
Iron binding site 2 out of 2 in the Structure of Cytochrome P450


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 2 of Structure of Cytochrome P450 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Fe472

b:12.4
occ:1.00
FE B:HEM472 0.0 12.4 1.0
NC B:HEM472 2.0 11.0 1.0
NA B:HEM472 2.0 14.4 1.0
O B:HOH473 2.0 5.9 1.0
ND B:HEM472 2.0 20.4 1.0
NB B:HEM472 2.0 15.2 1.0
SG B:CYS400 2.1 8.4 1.0
C4C B:HEM472 3.0 14.8 1.0
C1C B:HEM472 3.0 15.5 1.0
C1A B:HEM472 3.0 15.8 1.0
C4A B:HEM472 3.0 13.2 1.0
C4B B:HEM472 3.1 15.6 1.0
C1D B:HEM472 3.1 17.2 1.0
C4D B:HEM472 3.1 11.9 1.0
C1B B:HEM472 3.1 14.7 1.0
CB B:CYS400 3.2 15.8 1.0
CHD B:HEM472 3.4 17.2 1.0
CHC B:HEM472 3.4 13.2 1.0
CHA B:HEM472 3.4 14.5 1.0
CHB B:HEM472 3.4 10.9 1.0
CA B:CYS400 3.9 12.3 1.0
O B:HOH549 4.2 39.1 1.0
C2C B:HEM472 4.3 13.0 1.0
C3C B:HEM472 4.3 14.0 1.0
C2A B:HEM472 4.3 14.2 1.0
C3D B:HEM472 4.3 15.8 1.0
C3A B:HEM472 4.3 14.0 1.0
C2D B:HEM472 4.3 16.2 1.0
C3B B:HEM472 4.3 17.4 1.0
C2B B:HEM472 4.3 18.0 1.0
O B:ALA264 4.4 15.6 1.0
C B:CYS400 4.7 12.1 1.0
N B:ILE401 4.9 13.7 1.0
N B:GLY402 4.9 14.3 1.0

Reference:

H.Yeom, S.G.Sligar, H.Li, T.L.Poulos, A.J.Fulco. The Role of THR268 in Oxygen Activation of Cytochrome P450BM-3. Biochemistry V. 34 14733 1995.
ISSN: ISSN 0006-2960
PubMed: 7578081
DOI: 10.1021/BI00045A014
Page generated: Sun Dec 13 14:13:23 2020

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