Iron in PDB 1h2k: Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide, PDB code: 1h2k was solved by J.M.Elkins, K.S.Hewitson, L.A.Mcneill, I.Schlemminger, J.F.Seibel, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	18.50 / 2.15
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	86.161, 86.161, 146.656, 90.00, 90.00, 90.00
R / Rfree (%)	17.8 / 21.3

The binding sites of Iron atom in the Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide (pdb code 1h2k). This binding sites where shown within 5.0 Angstroms radius around Iron atom.
In total only one binding site of Iron was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide, PDB code: 1h2k:

Iron binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide


Mono view


Stereo pair view

A full contact list of Iron with other atoms in the Fe binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Hif-1 Alpha Fragment Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Fe1350 b:20.5 occ:1.00 OD2 A:ASP201 2.0 19.4 1.0 NE2 A:HIS279 2.1 23.8 1.0 NE2 A:HIS199 2.1 22.6 1.0 O2 A:OGA1351 2.1 24.4 1.0 O2' A:OGA1351 2.2 21.2 1.0 C1 A:OGA1351 2.8 24.8 1.0 C2 A:OGA1351 2.8 24.3 1.0 CE1 A:HIS279 3.0 22.2 1.0 CE1 A:HIS199 3.0 23.8 1.0 CG A:ASP201 3.1 22.0 1.0 CD2 A:HIS279 3.1 24.0 1.0 CD2 A:HIS199 3.1 22.0 1.0 OD1 A:ASP201 3.4 22.6 1.0 O A:HOH2103 3.9 26.1 1.0 O1 A:OGA1351 4.0 25.2 1.0 N1 A:OGA1351 4.1 21.7 1.0 ND1 A:HIS279 4.1 23.2 1.0 ND1 A:HIS199 4.2 21.9 1.0 CG A:HIS279 4.2 21.8 1.0 CG A:HIS199 4.3 22.2 1.0 CZ2 A:TRP296 4.3 22.3 1.0 CB A:ASP201 4.4 22.0 1.0 ND2 S:ASN803 4.7 29.8 1.0 CG S:ASN803 4.8 31.8 1.0 C4 A:OGA1351 4.9 23.1 1.0 CB S:ASN803 4.9 32.3 1.0

J.M.Elkins, K.S.Hewitson, L.A.Mcneill, J.F.Seibel, I.Schlemminger, C.Pugh, P.Ratcliffe, C.J.Schofield. Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1ALPHA J.Biol.Chem. V. 278 1802 2003.
ISSN: ISSN 0021-9258
PubMed: 12446723
DOI: 10.1074/JBC.C200644200